PRO/CON EDITORIALS:

Gordon L. Snider

Only Cell and Molecular Biology Can Lead to an Understanding of Pathogenesis of Lung Disease

Am. J. Respir. Crit. Care Med. 2004; 170: i [Full Text]  

Peter T. Macklem

Cell and Molecular Biology Is not the Only Way to a Better Understanding of Pathogenesis of Lung Disease

Am. J. Respir. Crit. Care Med. 2004; 170: ii [Full Text]  

Rebuttal from Dr. Snider

Am. J. Respir. Crit. Care Med. 2004; 170: iv [Full Text]  

Rebuttal from Dr. Macklem

Am. J. Respir. Crit. Care Med. 2004; 170: iv [Full Text]  

EDITORIALS:

Y. C. Gary Lee

Ongoing Search for Effective Intrapleural Therapy for Empyema: Is Streptokinase the Answer?

Am. J. Respir. Crit. Care Med. 2004; 170: 1-2 [Full Text]  

James F. Lewis and Ruud A. W. Veldhuizen

Analyzing Surfactant Metabolism in Humans: An Important First Step

Am. J. Respir. Crit. Care Med. 2004; 170: 2-3 [Full Text]  

Neil C. Thomson and Rekha Chaudhuri

Why Is Eosinophilic Bronchitis not Asthma?

Am. J. Respir. Crit. Care Med. 2004; 170: 4-5 [Full Text]  

Peter F. Barnes

Diagnosing Latent Tuberculosis Infection: Turning Glitter to Gold

Am. J. Respir. Crit. Care Med. 2004; 170: 5-6 [Full Text]  

David P. Speert and Joanna B. Goldberg

Burkholderia cepacia Complex and Cystic Fibrosis: In Search of the Smoking Gun

Am. J. Respir. Crit. Care Med. 2004; 170: 6-7 [Full Text]  

Diane R. Gold

Less Childhood Obesity—Less Persistence of Wheeze in Teenage Girls and Boys?

Am. J. Respir. Crit. Care Med. 2004; 170: 8-9 [Full Text]  

OCCASIONAL ESSAYS:

Peter T. Macklem

A Century of the Mechanics of Breathing

Am. J. Respir. Crit. Care Med. 2004; 170: 10-15 [Full Text]  

PULMONARY PERSPECTIVE:

Debra E. Weese-Mayer and Elizabeth M. Berry-Kravis

Genetics of Congenital Central Hypoventilation Syndrome: Lessons from a Seemingly Orphan Disease

Am. J. Respir. Crit. Care Med. 2004; 170: 16-21. First published online April 22 2004 as doi:10.1164/rccm.200402-245PP [Full Text]  

STATE OF THE ART:

Robert M. Kotloff, Vivek N. Ahya, and Stephen W. Crawford

Pulmonary Complications of Solid Organ and Hematopoietic Stem Cell Transplantation

Am. J. Respir. Crit. Care Med. 2004; 170: 22-48. First published online April 7 2004 as doi:10.1164/rccm.200309-1322SO [Abstract] [Full Text]  

ARTICLES:

A. Streptokinase for Empyema:

Andreas H. Diacon, Johan Theron, Macé M. Schuurmans, Bernard W. Van de Wal, and Chris T. Bolliger

Intrapleural Streptokinase for Empyema and Complicated Parapneumonic Effusions

Am. J. Respir. Crit. Care Med. 2004; 170: 49-53. First published online March 24 2004 as doi:10.1164/rccm.200312-1740OC [Abstract] [Full Text] [Online Supplement]  

B. Surfactant:

Wolfgang Bernhard, Christopher J. Pynn, Andreas Jaworski, Gunnar A. Rau, Jens M. Hohlfeld, Joachim Freihorst, Christian F. Poets, Dieter Stoll, and Anthony D. Postle

Mass Spectrometric Analysis of Surfactant Metabolism in Human Volunteers Using Deuteriated Choline

Am. J. Respir. Crit. Care Med. 2004; 170: 54-58. First published online March 24 2004 as doi:10.1164/rccm.200401-089OC [Abstract] [Full Text] [Online Supplement]  

C. Tuberculosis:

Toru Mori, Mitsunori Sakatani, Fumio Yamagishi, Tetsuya Takashima, Yoshiko Kawabe, Keiji Nagao, Eriko Shigeto, Nobuyuki Harada, Satoshi Mitarai, Masaji Okada, Katsuhiro Suzuki, Yoshikazu Inoue, Kazunari Tsuyuguchi, Yuka Sasaki, Gerald H. Mazurek, and Izuo Tsuyuguchi

Specific Detection of Tuberculosis Infection: An Interferon-–based Assay Using New Antigens

Am. J. Respir. Crit. Care Med. 2004; 170: 59-64. First published online April 1 2004 as doi:10.1164/rccm.200402-179OC [Abstract] [Full Text]  

Inger Brock, Karin Weldingh, Troels Lillebaek, Frank Follmann, and Peter Andersen

Comparison of Tuberculin Skin Test and New Specific Blood Test in Tuberculosis Contacts

Am. J. Respir. Crit. Care Med. 2004; 170: 65-69. First published online April 15 2004 as doi:10.1164/rccm.200402-232OC [Abstract] [Full Text]  

D. Cystic Fibrosis and Burkholderia:

Anthony De Soyza, Charles D. Ellis, C. M. Anjam Khan, Paul A. Corris, and Raquel Demarco de Hormaeche

Burkholderia cenocepacia Lipopolysaccharide, Lipid A, and Proinflammatory Activity

Am. J. Respir. Crit. Care Med. 2004; 170: 70-77. First published online March 24 2004 as doi:10.1164/rccm.200304-592OC [Abstract] [Full Text] [Online Supplement]  

E. Asthma in Adolescence:

Stefano Guerra, Anne L. Wright, Wayne J. Morgan, Duane L. Sherrill, Catharine J. Holberg, and Fernando D. Martinez

Persistence of Asthma Symptoms during Adolescence: Role of Obesity and Age at the Onset of Puberty

Am. J. Respir. Crit. Care Med. 2004; 170: 78-85. First published online March 17 2004 as doi:10.1164/rccm.200309-1224OC [Abstract] [Full Text]  

F. Sleep-disordered Breathing:

Susheel P. Patil, Naresh M. Punjabi, Hartmut Schneider, Christopher P. O'Donnell, Philip L. Smith, and Alan R. Schwartz

A Simplified Method for Measuring Critical Pressures during Sleep in the Clinical Setting

Am. J. Respir. Crit. Care Med. 2004; 170: 86-93. First published online April 7 2004 as doi:10.1164/rccm.200309-1239OC [Abstract] [Full Text] [Online Supplement]  

CORRESPONDENCE:

Samy Suissa, Pierre Ernst, Todd A. Lee, and Kevin B. Weiss

Inhaled Corticosteroids and Fracture Risk in COPD

Am. J. Respir. Crit. Care Med. 2004; 170: 94-95 [Full Text]  

Susan Chinn, Roberto J. Rona, Scott T. Weiss, and Stephanie Shore

Obesity and Asthma in Children

Am. J. Respir. Crit. Care Med. 2004; 170: 95-96 [Full Text]  

Robert P. Blankfield, Stephen J. Zyzanski, Darren R. Mansfield, and Matthew T. Naughton

Continuous Positive Airway Pressure in Obstructive Sleep Apnea and Heart Failure

Am. J. Respir. Crit. Care Med. 2004; 170: 96 [Full Text]  

Douglas C. Johnson and Ali El-Solh

Critical Care and Obstructive Sleep Apnea

Am. J. Respir. Crit. Care Med. 2004; 170: 97 [Full Text]  

Keertan Dheda, Graham Rook, Alimuddin Zumla, and Toru Mori

Peripheral T Cell Interferon- Responses and Latent Tuberculosis

Am. J. Respir. Crit. Care Med. 2004; 170: 97-98 [Full Text]  

Constantine A. Manthous, Yaw Amoateng-Adjepong, Henry E. Fessler, and Jerry A. Krishnan

Weaning by Protocol

Am. J. Respir. Crit. Care Med. 2004; 170: 98-100 [Full Text]  

Vincenzo Bellia, Filippo Catalano, Riccardo Pistelli, Raffaele Antonelli-Incalzi, and Paul L. Enright

Aging on Quality of Spirometry

Am. J. Respir. Crit. Care Med. 2004; 170: 100 [Full Text]  

Gordon L. Snider and Peter Macklem

Politics of Fundraising for Research

Am. J. Respir. Crit. Care Med. 2004; 170: 101 [Full Text]  

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