EDITORIALS:

Peter F. Barnes and Benjamin Wizel

Type 1 Cytokines and the Pathogenesis of Tuberculosis

Am. J. Respir. Crit. Care Med. 2000; 161: 1773-1774. [Full text]  

PRO/CON EDITORIALS:

Robert J. O. Davies and John R. Stradling

The Efficacy of Nasal Continuous Positive Airway Pressure in the Treatment of Obstructive Sleep Apnea Syndrome Is Proven

Am. J. Respir. Crit. Care Med. 2000; 161: 1775-1776. [Full text]  

John Wright and Trevor Sheldon

The Efficacy of Nasal Continuous Positive Airway Pressure in the Treatment of Obstructive Sleep Apnea Syndrome Is Not Proven

Am. J. Respir. Crit. Care Med. 2000; 161: 1776-1778. [Full text]  

REBUTTAL FROM DRS. DAVIES AND STRADLING

Am. J. Respir. Crit. Care Med. 2000; 161: 1778. [Full text]  

REBUTTAL FROM DRS. WRIGHT AND SHELDON

Am. J. Respir. Crit. Care Med. 2000; 161: a1778. [Full text]  

How It Really Happened:

ROBERT E. HYATT

How Flow Met Volume in Three-Dimensional Space

Am. J. Respir. Crit. Care Med. 2000; 161: 1779-1780. [Full text]  

CLINICAL COMMENTARY:

JEAN-LOUIS VINCENT, HAIBO ZHANG, CSABA SZABO, and JEAN-CHARLES PREISER

Effects of Nitric Oxide in Septic Shock

Am. J. Respir. Crit. Care Med. 2000; 161: 1781-1785. [Abstract] [Full text]  

PULMONARY PERSPECTIVE:

JONAS S. ERJEFÄLT and CARL G. A. PERSSON

New Aspects of Degranulation and Fates of Airway Mucosal Eosinophils

Am. J. Respir. Crit. Care Med. 2000; 161: 2074-2085. [Full text]  

ARTICLES:

Airway Biology and Disease:

ANTOINE O. MAGNAN, LAURENT G. MÉLY, CHRISTOPHE A. CAMILLA, MONIQUE M. BADIER, FÉLIX A. MONTERO-JULIAN, CHANTAL M. GUILLOT, BRICE B. CASANO, SABINE J. PRATO, VINCENT FERT, PIERRE BONGRAND, and DANIEL VERVLOET

Assessment of the Th1/Th2 Paradigm in Whole Blood in Atopy and Asthma . Increased IFN--producing CD8⁺ T Cells in Asthma

Am. J. Respir. Crit. Care Med. 2000; 161: 1790-1796. [Abstract] [Full text]  

LYLE J. PALMER, PAUL R. BURTON, JENNIE A. FAUX, ALAN L. JAMES, A. WILLIAM MUSK, and WILLIAM O. C. M. COOKSON

Independent Inheritance of Serum Immunoglobulin E Concentrations and Airway Responsiveness

Am. J. Respir. Crit. Care Med. 2000; 161: 1836-1843. [Abstract] [Full text]  

SATORU FUKUYAMA, HIROMASA INOUE, HISAMICHI AIZAWA, MASAHIRO OIKE, MOTOJI KITAURA, OSAMU YOSHIE, and NOBUYUKI HARA

Effect of Eotaxin and Platelet-activating Factor on Airway Inflammation and Hyperresponsiveness in Guinea Pigs in Vivo

Am. J. Respir. Crit. Care Med. 2000; 161: 1844-1849. [Abstract] [Full text]  

RYOICHI SUZUKI and ARTHUR N. FREED

Heparin Inhibits Eicosanoid Metabolism and Hyperventilation-induced Bronchoconstriction in Dogs

Am. J. Respir. Crit. Care Med. 2000; 161: 1850-1854. [Abstract] [Full text]  

RUDOLF A. JÖRRES, OLAF HOLZ, WOLFGANG ZACHGO, PETRA TIMM, SILKE KOSCHYK, BERND MÜLLER, FRIEDRICH GRIMMINGER, WERNER SEEGER, FRANK J. KELLY, CHRISTINE DUNSTER, THOMAS FRISCHER, GERD LUBEC, MARC WASCHEWSKI, AXEL NIENDORF, and HELGO MAGNUSSEN

The Effect of Repeated Ozone Exposures on Inflammatory Markers in Bronchoalveolar Lavage Fluid and Mucosal Biopsies

Am. J. Respir. Crit. Care Med. 2000; 161: 1855-1861. [Abstract] [Full text]  

GUSTAVO J. RODRIGO and CARLOS RODRIGO

First-Line Therapy for Adult Patients with Acute Asthma Receiving a Multiple-Dose Protocol of Ipratropium Bromide Plus Albuterol in the Emergency Department

Am. J. Respir. Crit. Care Med. 2000; 161: 1862-1868. [Abstract] [Full text]  

SUSANNA A. MCCOLLEY, VERONICA STELLMACH, STEVEN R. BOAS, MANU JAIN, and SUSAN E. CRAWFORD

Serum Vascular Endothelial Growth Factor Is Elevated in Cystic Fibrosis and Decreases with Treatment of Acute Pulmonary Exacerbation

Am. J. Respir. Crit. Care Med. 2000; 161: 1877-1880. [Abstract] [Full text]  

ELAINE LEE, TRACY ROBERTSON, JACQUELINE SMITH, and STEPHEN KILFEATHER

Leukotriene Receptor Antagonists and Synthesis Inhibitors Reverse Survival in Eosinophils of Asthmatic Individuals

Am. J. Respir. Crit. Care Med. 2000; 161: 1881-1886. [Abstract] [Full text]  

TORU OGA, KOICHI NISHIMURA, MITSUHIRO TSUKINO, TAKASHI HAJIRO, AKIHIKO IKEDA, and TAKATERU IZUMI

The Effects of Oxitropium Bromide on Exercise Performance in Patients with Stable Chronic Obstructive Pulmonary Disease . A Comparison of Three Different Exercise Tests

Am. J. Respir. Crit. Care Med. 2000; 161: 1897-1901. [Abstract] [Full text]  

JOHANNES C. C. M.in`t VEEN, ANNELIES J. BEEKMAN, ELISABETH H. BEL, and PETER J. STERK

Recurrent Exacerbations in Severe Asthma Are Associated with Enhanced Airway Closure During Stable Episodes

Am. J. Respir. Crit. Care Med. 2000; 161: 1902-1906. [Abstract] [Full text]  

MICHEL M. VAN DEN HEUVEL, DENNIS C. W. POLAND, CASPER S. DE GRAAFF, ELISABETH C. M. HOEFSMIT, PIETER E. POSTMUS, ROB H. J. BEELEN, and WILLEM VAN DIJK

The Degree of Branching of the Glycans of ₁-Acid Glycoprotein in Asthma . A Correlation with Lung Function and Inflammatory Parameters

Am. J. Respir. Crit. Care Med. 2000; 161: 1972-1978. [Abstract] [Full text]  

DAWN D. HUNTER, ALLEN C. MYERS, and BRADLEY J. UNDEM

Nerve Growth Factor-Induced Phenotypic Switch in Guinea Pig Airway Sensory Neurons

Am. J. Respir. Crit. Care Med. 2000; 161: 1985-1990. [Abstract] [Full text]  

GERT-JAN BRAUNSTAHL, ALEX KLEINJAN, SHELLEY E. OVERBEEK, JAN-BAS PRINS, HENK C. HOOGSTEDEN, and WYTSKE J. FOKKENS

Segmental Bronchial Provocation Induces Nasal Inflammation in Allergic Rhinitis Patients

Am. J. Respir. Crit. Care Med. 2000; 161: 2051-2057. [Abstract] [Full text]  

EEVA-MAIJA KARJALAINEN, ANNIKA LAITINEN, MALCOLM SUE-CHU, ALAN ALTRAJA, LEIF BJERMER, and LAURI A. LAITINEN

Evidence of Airway Inflammation and Remodeling in Ski Athletes with and without Bronchial Hyperresponsiveness to Methacholine

Am. J. Respir. Crit. Care Med. 2000; 161: 2086-2091. [Abstract] [Full text]  

PEDRO C. AVILA, MARK R. SEGAL, HOFER H. WONG, HOMER A. BOUSHEY, and JOHN V. FAHY

Predictors of Late Asthmatic Response . Logistic Regression and Classification Tree Analyses

Am. J. Respir. Crit. Care Med. 2000; 161: 2092-2095. [Abstract] [Full text]  

JOHN D. BRANNAN, SANDRA D. ANDERSON, RUTH FREED, JOERG D. LEUPPI, HEIKKI KOSKELA, and HAK-KIM CHAN

Nedocromil Sodium Inhibits Responsiveness to Inhaled Mannitol in Asthmatic Subjects

Am. J. Respir. Crit. Care Med. 2000; 161: 2096-2099. [Abstract] [Full text]  

Asthma in Children:

KIM G. NIELSEN and HANS BISGAARD

Lung Function Response to Cold Air Challenge in Asthmatic and Healthy Children of 2-5 Years of Age

Am. J. Respir. Crit. Care Med. 2000; 161: 1805-1809. [Abstract] [Full text]  

CAROL H. BOSKEN, WILLIAM C. HUNT, WILLIAM E. LAMBERT, and JONATHAN M. SAMET

A Parental History of Asthma Is a Risk Factor for Wheezing and Nonwheezing Respiratory Illnesses in Infants Younger than 18 Months of Age

Am. J. Respir. Crit. Care Med. 2000; 161: 1810-1815. [Abstract] [Full text]  

WEI XUAN, JENNIFER K. PEAT, BRETT G. TOELLE, GUY B. MARKS, GEOFFREY BERRY, and ANN J. WOOLCOCK

Lung Function Growth and Its Relation to Airway Hyperresponsiveness and Recent Wheeze . Results from a Longitudinal Population Study

Am. J. Respir. Crit. Care Med. 2000; 161: 1820-1824. [Abstract] [Full text]  

URS FREY, KATRI MAKKONEN, TERRY WELLMAN, CAROLINE BEARDSMORE, and MICHAEL SILVERMAN

Alterations in Airway Wall Properties in Infants with a History of Wheezing Disorders

Am. J. Respir. Crit. Care Med. 2000; 161: 1825-1829. [Abstract] [Full text]  

PAUL W. DAVENPORT, MAURICE CRUZ, ARLENE A. STECENKO, and YEMISERACH KIFLE

Respiratory-related Evoked Potentials in Children with Life-threatening Asthma

Am. J. Respir. Crit. Care Med. 2000; 161: 1830-1835. [Abstract] [Full text]  

JOACHIM HEINRICH, BERND HOELSCHER, and H. ERICH WICHMANN

Decline of Ambient Air Pollution and Respiratory Symptoms in Children

Am. J. Respir. Crit. Care Med. 2000; 161: 1930-1936. [Abstract] [Full text]  

Critical Care:

ARTHUR J. NAM, ROY G. BROWER, HENRY E. FESSLER, and BRETT A. SIMON

Biologic Variability in Mechanical Ventilation Rate and Tidal Volume Does Not Improve Oxygenation or Lung Mechanics in Canine Oleic Acid Lung Injury

Am. J. Respir. Crit. Care Med. 2000; 161: 1797-1804. [Abstract] [Full text]  

AKINORI TAKEUCHI, ALEX VESELY, JOSHUA RUCKER, LEEOR Z. SOMMER, JANET TESLER, ELANA LAVINE, ARTHUR S. SLUTSKY, WOLFGANG H. MALECK, GEORGE VOLGYESI, LUDWIK FEDORKO, STEVE ISCOE, and JOSEPH A. FISHER

A Simple "New" Method to Accelerate Clearance of Carbon Monoxide

Am. J. Respir. Crit. Care Med. 2000; 161: 1816-1819. [Abstract] [Full text]  

ORESTE ORTOLANI, ANNA CONTI, ANGELO RAFFAELE DE GAUDIO, ELISA MORALDI, QUIRINA CANTINI, and GIANPAOLO NOVELLI

The Effect of Glutathione and N-Acetylcysteine on Lipoperoxidative Damage in Patients with Early Septic Shock

Am. J. Respir. Crit. Care Med. 2000; 161: 1907-1911. [Abstract] [Full text]  

SCOTT K. EPSTEIN, MICHAEL L. NEVINS, and JASON CHUNG

Effect of Unplanned Extubation on Outcome of Mechanical Ventilation

Am. J. Respir. Crit. Care Med. 2000; 161: 1912-1916. [Abstract] [Full text]  

LADISLAU KISS, HARTWIG SCHÜTTE, KONSTANTIN MAYER, HELMUT GRIMM, WINIFRIED PADBERG, WERNER SEEGER, and FRIEDRICH GRIMMINGER

Synthesis of Arachidonic Acid-Derived Lipoxygenase and Cytochrome P450 Products in the Intact Human Lung Vasculature

Am. J. Respir. Crit. Care Med. 2000; 161: 1917-1923. [Abstract] [Full text]  

PHILIPPE MARKOWICZ, MICHEL WOLFF, KAMEL DJEDAÏNI, YVES COHEN, JEAN CHASTRE, CHRISTOPHE DELCLAUX, JACQUES MERRER, BERNARD HERMAN, BENOIT VEBER, ALAIN FONTAINE, DIDIER DREYFUSS, and the ARDS Study Group

Multicenter Prospective Study of Ventilator-Associated Pneumonia During Acute Respiratory Distress Syndrome . Incidence, Prognosis, and Risk Factors

Am. J. Respir. Crit. Care Med. 2000; 161: 1942-1948. [Abstract] [Full text]  

NAHIT CAKAR, THOMAS VAN der KLOOT, MELYNNE YOUNGBLOOD, ALEX ADAMS, and AVI NAHUM

Oxygenation Response to a Recruitment Maneuver during Supine and Prone Positions in an Oleic Acid-Induced Lung Injury Model

Am. J. Respir. Crit. Care Med. 2000; 161: 1949-1956. [Abstract] [Full text]  

LUIZ M. MALBOUISSON, CORNELIUS J. BUSCH, LOUIS PUYBASSET, QIN LU, PHILLIPE CLUZEL, JEAN-JACQUES ROUBY, and the CT Scan ARDS Study Group

Role of the Heart in the Loss of Aeration Characterizing Lower Lobes in Acute Respiratory Distress Syndrome

Am. J. Respir. Crit. Care Med. 2000; 161: 2005-2012. [Abstract] [Full text]  

KAZUHITO KAWABATA, TETSUYA HAGIO, SHIGERU MATSUMOTO, SHINTARO NAKAO, SHINICHIRO ORITA, YOSHIYA AZE, and HIROYUKI OHNO

Delayed Neutrophil Elastase Inhibition Prevents Subsequent Progression of Acute Lung Injury Induced by Endotoxin Inhalation in Hamsters

Am. J. Respir. Crit. Care Med. 2000; 161: 2013-2018. [Abstract] [Full text]  

Lung Transplantation:

MARTINE REYNAUD-GAUBERT, PASCAL THOMAS, MONIQUE BADIER, PIERRE CAU, ROGER GIUDICELLI, and PIERRE FUENTES

Early Detection of Airway Involvement in Obliterative Bronchiolitis after Lung Transplantation . Functional and Bronchoalveolar Lavage Cell Findings

Am. J. Respir. Crit. Care Med. 2000; 161: 1924-1929. [Abstract] [Full text]  

JAN W. K. van den BERG, ALBERT GEERTSMA, WIM van der BIJ, GERARD H. KOËTER, WILLEM J. de BOER, DIRKJE S. POSTMA, and ELS M. ten VERGERT

Bronchiolitis Obliterans Syndrome after Lung Transplantation and Health-related Quality of Life

Am. J. Respir. Crit. Care Med. 2000; 161: 1937-1941. [Abstract] [Full text]  

JEAN-MARIE CHARPIN, MARC STERN, DOMINIQUE GRENET, and DOMINIQUE ISRAËL-BIET

Insulinlike Growth Factor-1 in Lung Transplants with Obliterative Bronchiolitis

Am. J. Respir. Crit. Care Med. 2000; 161: 1991-1998. [Abstract] [Full text]  

JOÃO A. DE ANDRADE, JOHN P. CROW, LILIANA VIERA, C. BRUCE ALEXANDER, K. RANDALL YOUNG, DAVID C. MCGIFFIN, GEORGE L. ZORN, SHA ZHU, SADIS MATALON, and ROBERT M. JACKSON

Protein Nitration, Metabolites of Reactive Nitrogen Species, and Inflammation in Lung Allografts

Am. J. Respir. Crit. Care Med. 2000; 161: 2035-2042. [Abstract] [Full text]  

ANTONIA FEHRENBACH, MATTHIAS OCHS, TOBIAS WARNECKE, THORSTEN WAHLERS, THORSTEN WITTWER, ANDREAS SCHMIEDL, SEBASTIAN ELKI, DANIEL MEYER, JOACHIM RICHTER, and HEINZ FEHRENBACH

Beneficial Effect of Lung Preservation Is Related to Ultrastructural Integrity of Tubular Myelin after Experimental Ischemia and Reperfusion

Am. J. Respir. Crit. Care Med. 2000; 161: 2058-2065. [Abstract] [Full text]  

Pulmonary Fibrosis and Inflammation:

JÜRGEN BEHR, BARBARA DEGENKOLB, THOMAS BEINERT, FRITZ KROMBACH, and CLAUS VOGELMEIER

Pulmonary Glutathione Levels in Acute Episodes of Farmer's Lung

Am. J. Respir. Crit. Care Med. 2000; 161: 1968-1971. [Abstract] [Full text]  

RICHARD P. MARSHALL, ROBIN J. MCANULTY, and GEOFFREY J. LAURENT

Angiotensin II Is Mitogenic for Human Lung Fibroblasts via Activation of the Type 1 Receptor

Am. J. Respir. Crit. Care Med. 2000; 161: 1999-2004. [Abstract] [Full text]  

HIRONOBU HAMADA, VAL VALLYATHAN, CARLYNE D. COOL, ELIZABETH BARKER, YOSHIKAZU INOUE, and LEE S. NEWMAN

Mast Cell Basic Fibroblast Growth Factor in Silicosis

Am. J. Respir. Crit. Care Med. 2000; 161: 2026-2034. [Abstract] [Full text]  

NARAYANAN VENKATESAN, TAKAE EBIHARA, PETER J. ROUGHLEY, and MARA S. LUDWIG

Alterations in Large and Small Proteoglycans in Bleomycin-Induced Pulmonary Fibrosis in Rats

Am. J. Respir. Crit. Care Med. 2000; 161: 2066-2073. [Abstract] [Full text]  

Sleep-Disordered Breathing:

HARTMUT SCHNEIDER, DANIEL J. O'HEARN, KAREN LEBLANC, PHILIP L. SMITH, CHRISTOPHER P. O'DONNELL, DAVID W. EISELE, J. H. PETER, and ALAN R. SCHWARTZ

High-flow Transtracheal Insufflation Treats Obstructive Sleep Apnea . A Pilot Study

Am. J. Respir. Crit. Care Med. 2000; 161: 1869-1876. [Abstract] [Full text]  

TAKASHI NISHINO, TOHRU IDE, TOMOKO SUDO, and JIRO SATO

Inhaled Furosemide Greatly Alleviates the Sensation of Experimentally Induced Dyspnea

Am. J. Respir. Crit. Care Med. 2000; 161: 1963-1967. [Abstract] [Full text]  

EARL D. KING, CHRISTOPHER P. O'DONNELL, PHILIP L. SMITH, and ALAN R. SCHWARTZ

A Model of Obstructive Sleep Apnea in Normal Humans . Role of the Upper Airway

Am. J. Respir. Crit. Care Med. 2000; 161: 1979-1984. [Abstract] [Full text]  

Miscellaneous:

GEN YAMADA, NORIHARU SHIJUBO, KATSUNORI SHIGEHARA, HARUKI OKAMURA, MASASHI KURIMOTO, and SHOSAKU ABE

Increased Levels of Circulating Interleukin-18 in Patients with Advanced Tuberculosis

Am. J. Respir. Crit. Care Med. 2000; 161: 1786-1789. [Abstract] [Full text]  

MARTIN R. MILLER, BARRIE JONES, YONG XU, OLE FIND PEDERSEN, and PHILIP H. QUANJER

Peak Expiratory Flow Profiles Delivered by Pump Systems . Limitations due to Wave Action

Am. J. Respir. Crit. Care Med. 2000; 161: 1887-1896. [Abstract] [Full text]  

KANG-HYEON CHOE, YONG-TAE KIM, TAE-SUN SHIM, CHAE-MAN LIM, SANG-DO LEE, YOUNSUCK KOH, WOO-SUNG KIM, DONG-SOON KIM, JIN-SOOK RYU, and WON-DONG KIM

Closing Volume Influences the Postural Effect on Oxygenation in Unilateral Lung Disease

Am. J. Respir. Crit. Care Med. 2000; 161: 1957-1962. [Abstract] [Full text]  

FENG QING, TIMOTHY J. McCARTHY, JOANNE MARKHAM, and DANIEL P. SCHUSTER

Pulmonary Angiotensin-converting Enzyme (ACE) Binding and Inhibition in Humans . A Positron Emission Tomography Study

Am. J. Respir. Crit. Care Med. 2000; 161: 2019-2025. [Abstract] [Full text]  

JEFFREY A. KAZZAZ, STUART HOROWITZ, JING XU, POONAM KHULLAR, MICHAEL S. NIEDERMAN, ALAN M. FEIN, ZAHRA ZAKERI, LIN LIN, and GREGORY C. RHODES

Differential Patterns of Apoptosis in Resolving and Nonresolving Bacterial Pneumonia

Am. J. Respir. Crit. Care Med. 2000; 161: 2043-2050. [Abstract] [Full text]  

CASE REPORTS:

HAROLD L. MANNING and JAMES C. LEITER

Respiratory Control and Respiratory Sensation in a Patient with a Ganglioglioma within the Dorsocaudal Brain Stem

Am. J. Respir. Crit. Care Med. 2000; 161: 2100-2106. [Abstract] [Full text]  

PHILIP JOHN BERGER, ELIZABETH MICHALINA SKUZA, VOJTA BRODECKY, SUSAN MARGARET CRANAGE, THOMAS MICHAEL ADAMSON, and MALCOLM HOWARD WILKINSON

Unusual Respiratory Response to Oxygen in an Infant with Repetitive Cyanotic Episodes

Am. J. Respir. Crit. Care Med. 2000; 161: 2107-2111. [Abstract] [Full text]  

CORRESPONDENCE:

Arthur N. Freed, Sandra D. Anderson, Evangelia Daviskas, E.R. McFadden,Jr., J.A. Nelson, M.E. Skowronski, and K.A. Lenner

THERMALLY INDUCED ASTHMA AND AIRWAY DRYING

Am. J. Respir. Crit. Care Med. 2000; 161: 2112-2113. [Full text]  

Anthony P. Pietropaoli, Peter T. Perkins, Irene B. Perillo, Richard W. Hyde, Urs Scherrer, Claudio Sartori, Hervé Duplain, and Thilo Busch

Am. J. Respir. Crit. Care Med. 2000; 161: 2113-2114. [Full text]  

Lars Peter Nielsen, Ronald Dahl, Eric Derom, and Romain Pauwels

Am. J. Respir. Crit. Care Med. 2000; 161: 2115. [Full text]  

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