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Contents: Volume 161, Issue 3; March 1, 2000   [Index by Author] 
       EDITORIALS
       HOW IT REALLY HAPPENED
       STATE OF THE ART
       Airway Biology, Asthma, and COPD
       Critical Care
       Neuromuscular Control of Breathing
       Pediatric Pulmonary Disease
       Pulmonary Infections
       Pulmonary Vascular Disease, Pulmonary Function Testing, and Miscellaneous
       Supplement:
"Supplement: Asthma: The Important Questions Part 4"
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EDITORIALS:

Harvey E. Marshall and Jonathan S. Stamler
NO Waiting to Exhale in Asthma
Am. J. Respir. Crit. Care Med. 2000; 161: 685-687. [Full text]  

Andrea Rossi
Noninvasive Ventilation Has Not Been Shown To Be Ineffective in Stable COPD
Am. J. Respir. Crit. Care Med. 2000; 161: 688-689. [Full text]  

Nicholas S. Hill
Noninvasive Ventilation Has Been Shown to be Ineffective in Stable COPD
Am. J. Respir. Crit. Care Med. 2000; 161: 689-690. [Full text]  

ANDREA ROSSI
REBUTTAL FROM DR. ROSSI
Am. J. Respir. Crit. Care Med. 2000; 161: 691a. [Full text]  

Nicholas S. Hill
REBUTTAL FROM DR. HILL
Am. J. Respir. Crit. Care Med. 2000; 161: 691b. [Full text]  


HOW IT REALLY HAPPENED:

ALFRED P. FISHMAN
The Fick Principle and the Steady State
Am. J. Respir. Crit. Care Med. 2000; 161: 692-693. [Full text]  


STATE OF THE ART:

JOHN L. FAUL, GERALD J. BERRY, THOMAS V. COLBY, STEPHEN J. RUOSS, MATTHEW B. WALTER, GLENN D. ROSEN, and THOMAS A. RAFFIN
Thoracic Lymphangiomas, Lymphangiectasis, Lymphangiomatosis, and Lymphatic Dysplasia Syndrome
Am. J. Respir. Crit. Care Med. 2000; 161: 1037-1046. [Full text]  


ARTICLES:

Airway Biology, Asthma, and COPD:

JOHN F. HUNT, KEZHONG FANG, RAJESH MALIK, ASHLEY SNYDER, NEIL MALHOTRA, THOMAS A. E. PLATTS-MILLS, and BENJAMIN GASTON
Endogenous Airway Acidification . Implications for Asthma Pathophysiology
Am. J. Respir. Crit. Care Med. 2000; 161: 694-699. [Abstract] [Full text]  

TARJA LAITINEN, VESA OLLIKAINEN, CONXI LÁZARO, PAULA KAUPPI, RAFAEL de CID, JOSEP MARIA ANTÓ, XAVIER ESTIVILL, HEIKKI LOKKI, HEIKKI MANNILA, LAURI A. LAITINEN, and JUHA KERE
Association Study of the Chromosomal Region Containing the FCER2 Gene Suggests It Has a Regulatory Role in Atopic Disorders
Am. J. Respir. Crit. Care Med. 2000; 161: 700-706. [Abstract] [Full text]  

EVA C. CREUTZBERG, ANNEMIE M. W. J. SCHOLS, CLARIE A. P. M. WELING-SCHEEPERS, WIM A. BUURMAN, and EMIEL F. M. WOUTERS
Characterization of Nonresponse to High Caloric Oral Nutritional Therapy in Depleted Patients with Chronic Obstructive Pulmonary Disease
Am. J. Respir. Crit. Care Med. 2000; 161: 745-752. [Abstract] [Full text]  

MARK D. SCHLUCHTER, JAMES K. STOLLER, ALAN F. BARKER, A. SONIA BUIST, RONALD G. CRYSTAL, JAMES F. DONOHUE, ROBERT J. FALLAT, GERARD M. TURINO, CAROL E. VREIM, and MARGARET C. WU
Feasibility of a Clinical Trial of Augmentation Therapy for alpha 1-Antitrypsin Deficiency
Am. J. Respir. Crit. Care Med. 2000; 161: 796-801. [Abstract] [Full text]  

DAVID H. AU, ROZENN N. LEMAITRE, J. RANDALL CURTIS, NICHOLAS L. SMITH, and BRUCE M. PSATY
The Risk of Myocardial Infarction Associated with Inhaled beta -Adrenoceptor Agonists
Am. J. Respir. Crit. Care Med. 2000; 161: 827-830. [Abstract] [Full text]  

ALEXANDRE DUGUET, KELTOUM BIYAH, ELEANOR MINSHALL, RUTE GOMES, CHONG-GANG WANG, MAJDA TAOUDI-BENCHEKROUN, JASON H. T. BATES, and DAVID H. EIDELMAN
Bronchial Responsiveness among Inbred Mouse Strains . Role of Airway Smooth-Muscle Shortening Velocity
Am. J. Respir. Crit. Care Med. 2000; 161: 839-848. [Abstract] [Full text]  

MARIA MONTES de OCA and BARTOLOME R. CELLI
Respiratory Muscle Recruitment and Exercise Performance in Eucapnic and Hypercapnic Severe Chronic Obstructive Pulmonary Disease
Am. J. Respir. Crit. Care Med. 2000; 161: 880-885. [Abstract] [Full text]  

HAMID SAHEBJAMI and EAKACHAI SATHIANPITAYAKUL
Influence of Body Weight on the Severity of Dyspnea in Chronic Obstructive Pulmonary Disease
Am. J. Respir. Crit. Care Med. 2000; 161: 886-890. [Abstract] [Full text]  

NOBUYUKI HIZAWA, ETSURO YAMAGUCHI, EISEI JINUSHI, and YOSHIKAZU KAWAKAMI
A Common FCER1B Gene Promoter Polymorphism* Influences Total Serum IgE Levels in a Japanese Population
Am. J. Respir. Crit. Care Med. 2000; 161: 906-909. [Abstract] [Full text]  

ANABELLE M. OPAZO SAEZ, CHUN Y. SEOW, and PETER D. PARÉ
Peripheral Airway Smooth Muscle Mechanics in Obstructive Airways Disease
Am. J. Respir. Crit. Care Med. 2000; 161: 910-917. [Abstract] [Full text]  

SUNIL D. KUMAR, JORGE L. BRIEVA, IGNACIO DANTA, and ADAM WANNER
Transient Effect of Inhaled Fluticasone on Airway Mucosal Blood Flow in Subjects with and without Asthma
Am. J. Respir. Crit. Care Med. 2000; 161: 918-921. [Abstract] [Full text]  

SHUICHIRO MARUOKA, SHU HASHIMOTO, YASUHIRO GON, IKUKO TAKESHITA, and TAKASHI HORIE
PAF-induced RANTES Production by Human Airway Smooth Muscle Cells Requires Both p38 MAP Kinase and Erk
Am. J. Respir. Crit. Care Med. 2000; 161: 922-929. [Abstract] [Full text]  

ANGELA HACZKU, KATSUYUKI TAKEDA, ECKARD HAMELMANN, JOAN LOADER, ANTHONY JOETHAM, IMRE REDAI, CHARLES G. IRVIN, JAMES J. LEE, HITOSHI KIKUTANI, DANIEL CONRAD, and ERWIN W. GELFAND
CD23 Exhibits Negative Regulatory Effects on Allergic Sensitization and Airway Hyperresponsiveness
Am. J. Respir. Crit. Care Med. 2000; 161: 952-960. [Abstract] [Full text]  

JOHAN C. KIPS, BRIAN J. O'CONNOR, MARK D. INMAN, KLAS SVENSSON, ROMAIN A. PAUWELS, and PAUL M. O'BYRNE
A Long-term Study of the Antiinflammatory Effect of Low-dose Budesonide Plus Formoterol versus High-dose Budesonide in Asthma
Am. J. Respir. Crit. Care Med. 2000; 161: 996-1001. [Abstract] [Full text]  

MARINA SAETTA, GRAZIELLA TURATO, SIMONETTA BARALDO, ANNALISA ZANIN, FAUSTO BRACCIONI, CRISTINA E. MAPP, PIERO MAESTRELLI, GIORGIO CAVALLESCO, ALBERTO PAPI, and LEONARDO M. FABBRI
Goblet Cell Hyperplasia and Epithelial Inflammation in Peripheral Airways of Smokers with Both Symptoms of Chronic Bronchitis and Chronic Airflow Limitation
Am. J. Respir. Crit. Care Med. 2000; 161: 1016-1021. [Abstract] [Full text]  


Critical Care:

PETER KIEFER, ILYAS TUGTEKIN, HEIDE WIEDECK, HENDRIK BRACHT, GÖTZ GELDNER, MICHAEL GEORGIEFF, and PETER RADERMACHER
Effect of a Dopexamine-induced Increase in Cardiac Index on Splanchnic Hemodynamics in Septic Shock
Am. J. Respir. Crit. Care Med. 2000; 161: 775-779. [Abstract] [Full text]  

THOMAS J. MARTIN, JEFFREY D. HOVIS, JOSEPH P. COSTANTINO, MORRIS I. BIERMAN, MICHAEL P. DONAHOE, ROBERT M. ROGERS, JOHN W. KREIT, FRANK C. SCIURBA, RONALD A. STILLER, and MARK H. SANDERS
A Randomized, Prospective Evaluation of Noninvasive Ventilation for Acute Respiratory Failure
Am. J. Respir. Crit. Care Med. 2000; 161: 807-813. [Abstract] [Full text]  

SALVATORE GRASSO, FILOMENA PUNTILLO, LUCIANA MASCIA, GIOVANNI ANCONA, TOMMASO FIORE, FRANCESCO BRUNO, ARTHUR S. SLUTSKY, and V. MARCO RANIERI
Compensation for Increase in Respiratory Workload during Mechanical Ventilation . Pressure-Support versus Proportional-Assist Ventilation
Am. J. Respir. Crit. Care Med. 2000; 161: 819-826. [Abstract] [Full text]  

EDWARD P. INGENITO, RENE MORA, and LENA MARK
Pivotal Role of Anionic Phospholipids in Determining Dynamic Behavior of Lung Surfactant
Am. J. Respir. Crit. Care Med. 2000; 161: 831-838. [Abstract] [Full text]  

CLAUDE GUERIN, RAPHAELE GIRARD, JEAN-MARC SELLI, JEAN-PIERRE PERDRIX, and LOUIS AYZAC
Initial versus Delayed Acute Renal Failure in the Intensive Care Unit . A Multicenter Prospective Epidemiological Study
Am. J. Respir. Crit. Care Med. 2000; 161: 872-879. [Abstract] [Full text]  

MASAHIRO KAWASHIMA, TORU BANDO, TAKAYUKI NAKAMURA, NORITAKA ISOWA, MINGYAO LIU, SHINYA TOYOKUNI, SHIGEKI HITOMI, and HIROMI WADA
Cytoprotective Effects of Nitroglycerin in Ischemia-Reperfusion-Induced Lung Injury
Am. J. Respir. Crit. Care Med. 2000; 161: 935-943. [Abstract] [Full text]  

YOSHITAKA FUJII, SHELDON MAGDER, PETER CERNACEK, PETER GOLDBERG, YANG GUO, and SABAH N. A. HUSSAIN
Endothelin Receptor Blockade Attenuates Lipopolysaccharide-induced Pulmonary Nitric Oxide Production
Am. J. Respir. Crit. Care Med. 2000; 161: 982-989. [Abstract] [Full text]  

VALERIE NEWMAN, ROBERT F. GONZALEZ, MICHAEL A. MATTHAY, and LELAND G. DOBBS
A Novel Alveolar Type I Cell-Specific Biochemical Marker of Human Acute Lung Injury
Am. J. Respir. Crit. Care Med. 2000; 161: 990-995. [Abstract] [Full text]  

MARCO GARDINALI, EMMA BORRELLI, OSVALDO CHIARA, CLAES LUNDBERG, PIETRO PADALINO, LUISA CONCIATO, CRISTINA CAFARO, STEFANO LAZZI, PIETRO LUZI, PIER PAOLO GIOMARELLI, and ANGELO AGOSTONI
Inhibition of CD11-CD18 Complex Prevents Acute Lung Injury and Reduces Mortality after Peritonitis in Rabbits
Am. J. Respir. Crit. Care Med. 2000; 161: 1022-1029. [Abstract] [Full text]  

MORIO NAKAMURA, SEITARO FUJISHIMA, MAKOTO SAWAFUJI, AKITOSHI ISHIZAKA, TSUYOSHI OGUMA, KENZO SOEJIMA, HIROAKI MATSUBARA, SADATOMO TASAKA, KOJI KIKUCHI, KOICHI KOBAYASHI, EIJI IKEDA, MICHAEL SADICK, CAROLINE A. HEBERT, NAOKI AIKAWA, MINORU KANAZAWA, and KAZUHIRO YAMAGUCHI
Importance of Interleukin-8 in the Development of Reexpansion Lung Injury in Rabbits
Am. J. Respir. Crit. Care Med. 2000; 161: 1030-1036. [Abstract] [Full text]  


Neuromuscular Control of Breathing:

MARC ESTENNE, CHRISTOPHE PINET, and ANDRÉ DE TROYER
Abdominal Muscle Strength in Patients with Tetraplegia
Am. J. Respir. Crit. Care Med. 2000; 161: 707-712. [Abstract] [Full text]  

MARC H. LAVIETES, CARLOS W. SANCHEZ, LANA A. TIERSKY, NEIL S. CHERNIACK, and BENJAMIN H. NATELSON
Psychological Profile and Ventilatory Response to Inspiratory Resistive Loading
Am. J. Respir. Crit. Care Med. 2000; 161: 737-744. [Abstract] [Full text]  

ISABELLE ARNULF, THOMAS SIMILOWSKI, FRANÇOIS SALACHAS, LUCILE GARMA, SELMA MEHIRI, VALERIE ATTALI, VALERIE BEHIN-BELLHESEN, VINCENT MEININGER, and JEAN-PHILIPPE DERENNE
Sleep Disorders and Diaphragmatic Function in Patients with Amyotrophic Lateral Sclerosis
Am. J. Respir. Crit. Care Med. 2000; 161: 849-856. [Abstract] [Full text]  

LARRY FINDLEY, CAROL SMITH, JOANNA HOOPER, MICHAEL DINEEN, and PAUL M. SURATT
Treatment with Nasal CPAP Decreases Automobile Accidents in Patients with Sleep Apnea
Am. J. Respir. Crit. Care Med. 2000; 161: 857-859. [Abstract] [Full text]  

RUTH N. KINGSHOTT, MARJORIE VENNELLE, CAROL J. HOY, HEATHER M. ENGLEMAN, IAN J. DEARY, and NEIL J. DOUGLAS
Predictors of Improvements in Daytime Function Outcomes with CPAP Therapy
Am. J. Respir. Crit. Care Med. 2000; 161: 866-871. [Abstract] [Full text]  

DANIEL A. STOFAN, LEIGH A. CALLAHAN, ANTHONY F. DiMARCO, DAVID E. NETHERY, and GERALD S. SUPINSKI
Modulation of Release of Reactive Oxygen Species by the Contracting Diaphragm
Am. J. Respir. Crit. Care Med. 2000; 161: 891-898. [Abstract] [Full text]  


Pediatric Pulmonary Disease:

MARCUS H. JONES, STEPHANIE D. DAVIS, JEFFREY A. KISLING, JOHN M. HOWARD, ROBERT CASTILE, and ROBERT S. TEPPER
Flow Limitation in Infants Assessed by Negative Expiratory Pressure
Am. J. Respir. Crit. Care Med. 2000; 161: 713-717. [Abstract] [Full text]  

CHRISTOPHE DELACOURT, HUBERT LORINO, MARTINE HERVE-GUILLOT, PHILIPPE REINERT, ALAIN HARF, and BRUNO HOUSSET
Use of the Forced Oscillation Technique to Assess Airway Obstruction and Reversibility in Children
Am. J. Respir. Crit. Care Med. 2000; 161: 730-736. [Abstract] [Full text]  

MANFRED MODL, ERNST EBER, ELISABETH WEINHANDL, WILFRIED GRUBER, and MAXIMILIAN S. ZACH
Assessment of Bronchodilator Responsiveness in Infants with Bronchiolitis . A Comparison of the Tidal and the Raised Volume Rapid Thoracoabdominal Compression Technique
Am. J. Respir. Crit. Care Med. 2000; 161: 763-768. [Abstract] [Full text]  

M. Z. NORZILA, KELLIE FAKES, RICHARD L. HENRY, JODIE SIMPSON, and PETER G. GIBSON
Interleukin-8 Secretion and Neutrophil Recruitment Accompanies Induced Sputum Eosinophil Activation in Children with Acute Asthma
Am. J. Respir. Crit. Care Med. 2000; 161: 769-774. [Abstract] [Full text]  

JOEL SCHWARTZ, KIRSI L. TIMONEN, and JUHA PEKKANEN
Respiratory Effects of Environmental Tobacco Smoke in a Panel Study of Asthmatic and Symptomatic Children
Am. J. Respir. Crit. Care Med. 2000; 161: 802-806. [Abstract] [Full text]  

MICHAEL WILSCHANSKI, CHAGIT FAMINI, HANNAH BLAU, JOSEPH RIVLIN, ARIEH AUGARTEN, AVRAHAM AVITAL, BATSHEVA KEREM, and EITAN KEREM
A Pilot Study of the Effect of Gentamicin on Nasal Potential Difference Measurements in Cystic Fibrosis Patients Carrying Stop Mutations
Am. J. Respir. Crit. Care Med. 2000; 161: 860-865. [Abstract] [Full text]  

THOMAS FERKOL, ELIZABETH ECKMAN, SHADI SWAIDANI, CATHERINE SILSKI, and PAMELA DAVIS
Transport of Bifunctional Proteins Across Respiratory Epithelial Cells via the Polymeric Immunoglobulin Receptor
Am. J. Respir. Crit. Care Med. 2000; 161: 944-951. [Abstract] [Full text]  

LAWRENCE M. NOGEE, SUSAN E. WERT, SHERRI A. PROFFIT, WILLIAM M. HULL, and JEFFREY A. WHITSETT
Allelic Heterogeneity in Hereditary Surfactant Protein B (SP-B) Deficiency
Am. J. Respir. Crit. Care Med. 2000; 161: 973-981. [Abstract] [Full text]  

MASSIMO SCOLLO, STEFANIA ZANCONATO, RICCARDO ONGARO, CRISTINA ZARAMELLA, FRANCO ZACCHELLO, and EUGENIO BARALDI
Exhaled Nitric Oxide and Exercise-Induced Bronchoconstriction in Asthmatic Children
Am. J. Respir. Crit. Care Med. 2000; 161: 1047-1050. [Abstract] [Full text]  

ANTONIO MANSI, SALVATORE CUCCHIARA, LUIGI GRECO, PAOLA SARNELLI, CHIARA PISANTI, MARIA TERESA FRANCO, and FRANCESCA SANTAMARIA
Bronchial Hyperresponsiveness in Children and Adolescents with Crohn's Disease
Am. J. Respir. Crit. Care Med. 2000; 161: 1051-1054. [Abstract] [Full text]  


Pulmonary Infections:

GERALD PANG, ROBERT CLANCY, MA CONG, MARIA ORTEGA, REN ZHIGANG, and GLEN REEVES
Influenza Virus Inhibits Lysozyme Secretion by Sputum Neutrophils in Subjects with Chronic Bronchial Sepsis
Am. J. Respir. Crit. Care Med. 2000; 161: 718-722. [Abstract] [Full text]  

J.-Y. FAGON, H. PATRICK, D. W. HAAS, A. TORRES, C. GIBERT, W. G. CHEADLE, R. E. FALCONE, J. D. ANHOLM, F. PAGANIN, T. C. FABIAN, F. LILIENTHAL, and the Nosocomial Pneumonia Group
Treatment of Gram-positive Nosocomial Pneumonia . Prospective Randomized Comparison of Quinupristin/Dalfopristin versus Vancomycin
Am. J. Respir. Crit. Care Med. 2000; 161: 753-762. [Abstract] [Full text]  

KEVIN SCHWARTZMAN and DICK MENZIES
Tuberculosis Screening of Immigrants to Low-Prevalence Countries . A Cost-effectiveness Analysis
Am. J. Respir. Crit. Care Med. 2000; 161: 780-789. [Abstract] [Full text]  

EIKO HIDAKA, TAKAYUKI HONDA, ICHIRO UENO, YOSHITAKA YAMASAKI, KEISHI KUBO, and TSUTOMU KATSUYAMA
Sensitive Identification of Mycobacterial Species Using PCR-RFLP on Bronchial Washings
Am. J. Respir. Crit. Care Med. 2000; 161: 930-934. [Abstract] [Full text]  

TOSHI MIYAGAWA, SAYO HAMAGAMI, and NOBUKO TANIGAWA
Cryptococcus albidus-induced Summer-type Hypersensitivity Pneumonitis
Am. J. Respir. Crit. Care Med. 2000; 161: 961-966. [Abstract] [Full text]  

PAAVO PÄÄKKÖ, RIITTA KAARTEENAHO-WIIK, RAIMO PÖLLÄNEN, and YLERMI SOINI
Tenascin mRNA Expression at the Foci of Recent Injury in Usual Interstitial Pneumonia
Am. J. Respir. Crit. Care Med. 2000; 161: 967-972. [Abstract] [Full text]  


Pulmonary Vascular Disease, Pulmonary Function Testing, and Miscellaneous:

DOROTHY A. WHITE, PHILIP W. WONG, and ROBERT DOWNEY
The Utility of Open Lung Biopsy in Patients with Hematologic Malignancies
Am. J. Respir. Crit. Care Med. 2000; 161: 723-729. [Abstract] [Full text]  

LINDA GRIEVINK, FROUWKJE G. de WAART, EVERT G. SCHOUTEN, and FRANS J. KOK
Serum Carotenoids, alpha -Tocopherol, and Lung Function among Dutch Elderly
Am. J. Respir. Crit. Care Med. 2000; 161: 790-795. [Abstract] [Full text]  

JOHAN GRUNEWALD, MARY BERLIN, OLLE OLERUP, and ANDERS EKLUND
Lung T-Helper Cells Expressing T-cell Receptor AV2S3 Associate with Clinical Features of Pulmonary Sarcoidosis
Am. J. Respir. Crit. Care Med. 2000; 161: 814-818. [Abstract] [Full text]  

FRANCESCO PISTELLI, MATTEO BOTTAI, GIOVANNI VIEGI, FRANCESCO DI PEDE, LAURA CARROZZI, SANDRA BALDACCI, MARZIA PEDRESCHI, and CARLO GIUNTINI
Smooth Reference Equations for Slow Vital Capacity and Flow-Volume Curve Indexes
Am. J. Respir. Crit. Care Med. 2000; 161: 899-905. [Abstract] [Full text]  

KAZUHIRO MATSUI, KAZUYO TAKEDA, ZU-XI YU, JULIO VALENCIA, WILLIAM D. TRAVIS, JOEL MOSS, and VICTOR J. FERRANS
Downregulation of Estrogen and Progesterone Receptors in the Abnormal Smooth Muscle Cells in Pulmonary Lymphangioleiomyomatosis Following Therapy . An Immunohistochemical Study
Am. J. Respir. Crit. Care Med. 2000; 161: 1002-1009. [Abstract] [Full text]  

ELISABETH M. BAILE, GREGORY G. KING, NESTOR L. MÜLLER, YULIA D'YACHKOVA, EMMANUEL E. COCHE, PETER D. PARÉ, and JOHN R. MAYO
Spiral Computed Tomography Is Comparable to Angiography for the Diagnosis of Pulmonary Embolism
Am. J. Respir. Crit. Care Med. 2000; 161: 1010-1015. [Abstract] [Full text]  

ZEMIN DENG, FATEMEH HAGHIGHI, LETICIA HELLEBY, KISHA VANTERPOOL, EVELYN M. HORN, ROBYN J. BARST, SUSAN E. HODGE, JANE H. MORSE, and JAMES A. KNOWLES
Fine Mapping of PPH1, a Gene for Familial Primary Pulmonary Hypertension, to a 3-cM Region on Chromosome 2q33
Am. J. Respir. Crit. Care Med. 2000; 161: 1055-1059. [Abstract] [Full text]  


SUPPLEMENT: "Supplement: Asthma: The Important Questions Part 4"

ANN J. WOOLCOCK and PETER J. BARNES
Introduction
Am. J. Respir. Crit. Care Med. 2000; 161: 157S. [Full text]  

JEFFREY J. FREDBERG
Airway Smooth Muscle in Asthma . Perturbed Equilibria of Myosin Binding
Am. J. Respir. Crit. Care Med. 2000; 161: 158S-160. [Full text]  

CHENG-LI QUE, G. MAKSYM, and PETER T. MACKLEM
Deciphering the Homeokinetic Code of Airway Smooth Muscle
Am. J. Respir. Crit. Care Med. 2000; 161: 161S-163. [Full text]  

JULIAN SOLWAY
What Makes the Airways Contract Abnormally? Is It Inflammation?
Am. J. Respir. Crit. Care Med. 2000; 161: 164S-167. [Full text]  

JACK A. ELIAS
Airway Remodeling in Asthma . Unanswered Questions
Am. J. Respir. Crit. Care Med. 2000; 161: 168S-171. [Full text]  

PATRICK G. HOLT
Key Factors in the Development of Asthma: Atopy
Am. J. Respir. Crit. Care Med. 2000; 161: 172S-175. [Full text]  

PETER J. BARNES
Endogenous Inhibitory Mechanisms in Asthma
Am. J. Respir. Crit. Care Med. 2000; 161: 176S-181. [Full text]  

SØREN PEDERSEN
Why Does Airway Inflammation Persist? Is It Failure to Treat Early?
Am. J. Respir. Crit. Care Med. 2000; 161: 182S-185. [Full text]  

PAUL M. O'BYRNE
Why Does Airway Inflammation Persist? Is It Leukotrienes?
Am. J. Respir. Crit. Care Med. 2000; 161: 186S-187. [Full text]  

GARY P. ANDERSON
Interactions between Corticosteroids and beta -Adrenergic Agonists in Asthma Disease Induction, Progression, and Exacerbation
Am. J. Respir. Crit. Care Med. 2000; 161: 188S-196. [Full text]  

STEPHEN B. LIGGETT
beta 2-Adrenergic Receptor Pharmacogenetics
Am. J. Respir. Crit. Care Med. 2000; 161: 197S-201. [Full text]  

ANDREW J. SANDFORD and PETER D. PARÉ
The Genetics of Asthma . The Important Questions
Am. J. Respir. Crit. Care Med. 2000; 161: 202S-206. [Full text]  

JUDITH L. BLACK and PETER R. A. JOHNSON
What Determines Asthma Phenotype? Is It the Interaction between Allergy and the Smooth Muscle?
Am. J. Respir. Crit. Care Med. 2000; 161: 207S-210. [Full text]  

JO A. DOUGLASS and ROBYN E. O'HEHIR
What Determines Asthma Phenotype? . Respiratory Infections and Asthma
Am. J. Respir. Crit. Care Med. 2000; 161: 211S-214. [Full text]  

ANN J. WOOLCOCK and JENNIFER PEAT
What Is the Relationship between Airway Hyperresponsiveness and Atopy?
Am. J. Respir. Crit. Care Med. 2000; 161: 215S-217. [Full text]  


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