help button home button
AJRCCM
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH
Published ahead of print on February 28, 2008, doi:10.1164/rccm.200712-1776OC

Am. J. Respir. Crit. Care Med., Volume 177, Number 11, June 2008, 1201-1206

A more recent version of this article appeared on June 1, 2008
This Article
Right arrow Full Text (PDF)
Right arrow All Versions of this Article:
200712-1776OCv1
177/11/1201    most recent
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Coxson, H. O
Right arrow Articles by Lam, S.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Coxson, H. O
Right arrow Articles by Lam, S.

Submitted on December 3, 2007
Accepted on February 28, 2008

Airway Wall Thickness Assessed Using Computed Tomography and Optical Coherence Tomography

Harvey O Coxson1*, Brendan Quiney1, Don D Sin2, Li Xing3, Annette M McWilliams4, John R Mayo5, and Stephen Lam4

1 Department of Radiology, Vancouver General Hospital, Vancouver, BC, Canada; The James Hogg iCAPTURE Centre for Cardiovascular and Pulmonary Research at The Heart and Lung Center of St Paul's Hospital, Vancouver, BC, Canada, 2 The James Hogg iCAPTURE Centre for Cardiovascular and Pulmonary Research at The Heart and Lung Center of St Paul's Hospital, Vancouver, BC, Canada; Department of Medicine(Respiratory Division), The University of British Columbia, Vancouver, BC, Canada, 3 The James Hogg iCAPTURE Centre for Cardiovascular and Pulmonary Research at The Heart and Lung Center of St Paul's Hospital, Vancouver, BC, Canada, 4 British Columbia Cancer Agency, Vancouver, BC, Canada; Department of Medicine(Respiratory Division), The University of British Columbia, Vancouver, BC, Canada, 5 Department of Radiology, Vancouver General Hospital, Vancouver, BC, Canada

* To whom correspondence should be addressed. E-mail: harvey.coxson{at}vch.ca.

Rationale: Computed tomography (CT) has been shown to reliably measure the airway wall dimensions of medium to large airways. Optical coherence tomography (OCT) is a promising new micron-scale resolution imaging technique that can image small airways two millimeters in diameter or less. Objectives: To correlate OCT measurements of airway dimensions with measurements assessed using CT scans and lung function. Methods: Forty-four current and former smokers received spirometry, CT scans and OCT imaging at the time of bronchoscopy. Specific bronchial segments were identified and measured using the OCT images and three-dimensional reconstructions of the bronchial tree using CT. Measurements and Main Results: There was a strong correlation between CT and OCT measurements of lumen and wall area (r=0.84, p<0.001 and r=0.89 p<0.001 respectively). Compared to CT, OCT measurements were lower for both lumen and wall area by 31% and 66 %, respectively. The correlation between FEV1 % predicted and CT and OCT measured wall area (as percentage of the total area) of fifth generation airways was very strong (r = -0.79, r=-0.75)but the slope of the relationship was much steeper using OCT than using CT (y = -0.33x + 82, y = -0.1x + 78) indicating greater sensitivity of OCT in detecting changes in wall measurements that relate to FEV1. Conclusion: OCT can be used to measure airway wall dimensions. OCT may be more sensitive at detecting small airway wall changes that lead to FEV1 changes in individuals with obstructive airways disease.
Key words: Chronic Obstructive Pulmonary Disease




This article has been cited by other articles:


Home page
 J. Appl. Physiol.Home page
A. W. Sheel, J. A. Guenette, R. Yuan, L. Holy, J. R. Mayo, A. M. McWilliams, S. Lam, and H. O. Coxson
Evidence for dysanapsis using computed tomographic imaging of the airways in older ex-smokers
J Appl Physiol, November 1, 2009; 107(5): 1622 - 1628.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
H. O. Coxson, J. Mayo, S. Lam, G. Santyr, G. Parraga, and D. D. Sin
New and Current Clinical Imaging Techniques to Study Chronic Obstructive Pulmonary Disease
Am. J. Respir. Crit. Care Med., October 1, 2009; 180(7): 588 - 597.
[Abstract] [Full Text] [PDF]

Home page
 ThoraxHome page
P. J Mazzone
Give me a sign, any sign
Thorax, September 1, 2009; 64(9): 737 - 738.
[Full Text] [PDF]

Home page
 Proc Am Thorac SocHome page
V. R. Muzykantov
Chair's Summary
Proceedings of the ATS, August 15, 2009; 6(5): 398 - 402.
[Full Text] [PDF]

Home page
 Proc Am Thorac SocHome page
H. O. Coxson and S. Lam
Quantitative Assessment of the Airway Wall Using Computed Tomography and Optical Coherence Tomography
Proceedings of the ATS, August 15, 2009; 6(5): 439 - 443.
[Abstract] [Full Text] [PDF]

Home page
 Eur Respir JHome page
J. P. Williamson, A. L. James, M. J. Phillips, D. D. Sampson, D. R. Hillman, and P. R. Eastwood
Quantifying tracheobronchial tree dimensions: methods, limitations and emerging techniques
Eur. Respir. J., July 1, 2009; 34(1): 42 - 55.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
G. R. Washko, M. T. Dransfield, R. S. J. Estepar, A. Diaz, S. Matsuoka, T. Yamashiro, H. Hatabu, E. K. Silverman, W. C. Bailey, and J. J. Reilly
Airway wall attenuation: a biomarker of airway disease in subjects with COPD
J Appl Physiol, July 1, 2009; 107(1): 185 - 191.
[Abstract] [Full Text] [PDF]

Home page
 ChestHome page
J. P. Williamson, R. A. McLaughlin, M. J. Phillips, J. J. Armstrong, S. Becker, J. H. Walsh, D. D. Sampson, D. R. Hillman, and P. R. Eastwood
Using Optical Coherence Tomography To Improve Diagnostic and Therapeutic Bronchoscopy
Chest, July 1, 2009; 136(1): 272 - 276.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
J. D Maclay, R. A Rabinovich, and W. MacNee
Update in Chronic Obstructive Pulmonary Disease 2008
Am. J. Respir. Crit. Care Med., April 1, 2009; 179(7): 533 - 541.
[Full Text] [PDF]

Home page
 ChestHome page
T. E. Robinson, B. C. Trapnell, M. L. Goris, L. M. Quittell, and D. N. Cornfield
Quantitative Analysis of Longitudinal Response to Aerosolized Granulocyte-Macrophage Colony-Stimulating Factor in Two Adolescents With Autoimmune Pulmonary Alveolar Proteinosis
Chest, March 1, 2009; 135(3): 842 - 848.
[Abstract] [Full Text] [PDF]

Home page
 Proc Am Thorac SocHome page
R. San Jose Estepar, J. J. Reilly, E. K. Silverman, and G. R. Washko
Three-Dimensional Airway Measurements and Algorithms
Proceedings of the ATS, December 15, 2008; 5(9): 905 - 909.
[Abstract] [Full Text] [PDF]

Home page
 Proc Am Thorac SocHome page
M. Nishimura
Application of Three-Dimensional Airway Algorithms in a Clinical Study
Proceedings of the ATS, December 15, 2008; 5(9): 910 - 914.
[Abstract] [Full Text] [PDF]

Home page
 Proc Am Thorac SocHome page
H. O. Coxson
Quantitative Computed Tomography Assessment of Airway Wall Dimensions: Current Status and Potential Applications for Phenotyping Chronic Obstructive Pulmonary Disease
Proceedings of the ATS, December 15, 2008; 5(9): 940 - 945.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH
Proc. Am. Thorac. Soc. Am. J. Respir. Cell Mol. Biol.
Copyright © 2008 American Thoracic Society 		  New Orleans Int'l Conf