help button home button
AJRCCM
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH

Published ahead of print on November 7, 2007, doi:10.1164/rccm.200709-1398OC

Am. J. Respir. Crit. Care Med., Volume 177, Number 5, March 2008, 524-530

A more recent version of this article appeared on March 1, 2008
This Article
Right arrow Full Text (PDF)
Right arrow All Versions of this Article:
200709-1398OCv1
177/5/524    most recent
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Slatore, C. G
Right arrow Articles by White, E.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Slatore, C. G
Right arrow Articles by White, E.

Submitted on September 20, 2007
Accepted on November 7, 2007

Supplemental Multivitamins, Vitamin C, Vitamin E, and Folate Does Not Reduce the Risk of Lung Cancer

Christopher G Slatore1*, Alyson J Littman2, David H Au3, Jessie A Satia4, and Emily White5

1 Division of Pulmonary and Critical Care Medicine, University of Washington, Seattle, WA, USA, 2 Department of Epidemiology, University of Washington, Seattle, WA, USA; Epidemiologic Research and Information Center, VA Puget Sound Health Care System, Seattle, WA, USA, 3 Division of Pulmonary and Critical Care Medicine, University of Washington, Seattle, WA, USA; Health Services Research and Development, VA Puget Sound Health Care System, Seattle, WA, USA, 4 Departments of Epidemiology and Nutrition, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA, 5 Department of Epidemiology, University of Washington, Seattle, WA, USA; Cancer Prevention Program, Fred Hutchinson Cancer Research Center, Seattle, WA, USA

* To whom correspondence should be addressed. E-mail: cslatore{at}u.washington.edu.

Rationale: Lung cancer is the leading cause of cancer-related mortality in the US. Although supplements are used by half the population, limited information is available about their specific effect on lung cancer risk. Objective: To explore the association of supplemental multivitamins, vitamin C, vitamin E, and folate with incident lung cancer. Methods: Prospective cohort of 77,721 men and women aged 50 - 76 years from Washington State in the VITamins And Lifestyle VITAL study. Cases were identified through the Seattle-Puget Sound SEER cancer registry. Measurements: Hazard ratios (HRs) for incident lung cancer according to 10 year average daily use of supplemental multivitamins, vitamin C, vitamin E, and folate. Results: 521 cases of lung cancer were identified. Adjusting for smoking, age, and gender, there was no inverse association with any supplement. Supplemental vitamin E was associated with a small increased risk of lung cancer (HR 1.05 for every 100 mg/day increase in dose, 95% CI, 1.00 - 1.09, P = .033). This risk of supplemental vitamin E was largely confined to current smokers (HR 1.11 for every 100 mg/day increase, 95% CI, 1.03 - 1.19, P <.01) and was greatest for non-small cell lung cancer (HR 1.07 for every 100 mg/day increase, 95% CI, 1.02 - 1.12, P = .004). Conclusions: Supplemental multivitamins, vitamin C, vitamin E, and folate were not associated with a decreased risk of lung cancer. Supplemental vitamin E was associated with a small increased risk. Patients should be counseled against using these supplements to prevent lung cancer.


Key words: bronchial neoplasm, diet, dietary supplements, public health




This article has been cited by other articles:


Home page
JAMAHome page
M. Ebbing, K. H. Bonaa, O. Nygard, E. Arnesen, P. M. Ueland, J. E. Nordrehaug, K. Rasmussen, I. Njolstad, H. Refsum, D. W. Nilsen, et al.
Cancer Incidence and Mortality After Treatment With Folic Acid and Vitamin B12
JAMA, November 18, 2009; 302(19): 2119 - 2126.
[Abstract] [Full Text] [PDF]


Home page
Am J EpidemiolHome page
K. Svennevig
RE: "LONG-TERM USE OF {beta}-CAROTENE, RETINOL, LYCOPENE, AND LUTEIN SUPPLEMENTS AND LUNG CANCER RISK: RESULTS FROM THE VITAMINS AND LIFESTYLE (VITAL) STUDY"
Am. J. Epidemiol., August 1, 2009; 170(3): 401 - 402.
[Full Text] [PDF]


Home page
Am. J. Respir. Crit. Care Med.Home page
S. Dubey and C. A. Powell
Update in Lung Cancer 2008
Am. J. Respir. Crit. Care Med., May 15, 2009; 179(10): 860 - 868.
[Full Text] [PDF]


Home page
Cancer Epidemiol. Biomarkers Prev.Home page
Q. Yang, R. M. Bostick, J.M. Friedman, and W. D. Flanders
Serum Folate and Cancer Mortality Among U.S. Adults: Findings from the Third National Health and Nutritional Examination Survey Linked Mortality File
Cancer Epidemiol. Biomarkers Prev., May 1, 2009; 18(5): 1439 - 1447.
[Abstract] [Full Text] [PDF]


Home page
Cancer Epidemiol. Biomarkers Prev.Home page
C. G. Slatore, D. H. Au, A. J. Littman, J. A. Satia, and E. White
Association of Nonsteroidal Anti-Inflammatory Drugs with Lung Cancer: Results from a Large Cohort Study
Cancer Epidemiol. Biomarkers Prev., April 1, 2009; 18(4): 1203 - 1207.
[Abstract] [Full Text] [PDF]


Home page
Am J EpidemiolHome page
J. A. Satia, A. Littman, C. G. Slatore, J. A. Galanko, and E. White
Long-term Use of {beta}-Carotene, Retinol, Lycopene, and Lutein Supplements and Lung Cancer Risk: Results From the VITamins And Lifestyle (VITAL) Study
Am. J. Epidemiol., April 1, 2009; 169(7): 815 - 828.
[Abstract] [Full Text] [PDF]


Home page
Am. J. Respir. Crit. Care Med.Home page
A. E. Dembe
Can Moderate Doses of Vitamin E Protect against Lung Cancer?
Am. J. Respir. Crit. Care Med., September 15, 2008; 178(6): 653 - 653.
[Full Text] [PDF]


Home page
Am. J. Respir. Crit. Care Med.Home page
C. G. Slatore, D. H. Au, and E. White
Can Moderate Doses of Vitamin E Protect against Lung Cancer?
Am. J. Respir. Crit. Care Med., September 15, 2008; 178(6): 653 - 654.
[Full Text] [PDF]


Home page
Am. J. Respir. Crit. Care Med.Home page
T. Byers
Nutrition and Lung Cancer: Lessons from the Differing Effects of Foods and Supplements
Am. J. Respir. Crit. Care Med., March 1, 2008; 177(5): 470 - 471.
[Full Text] [PDF]




HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH
Proc. Am. Thorac. Soc. Am. J. Respir. Cell Mol. Biol.
Copyright © 2007 American Thoracic Society
  CCM abstracts