Hispanics are individuals whose ancestry can be traced to Spain and/or areas previously under Spanish control (e.g., Mexico, Puerto Rico). They are a rapidly growing subset of the population of the United States and are quite diverse in their racial ancestry, country of origin, area of residence, socioeconomic status, tobacco use, and access to healthcare. Current evidence suggests that the prevalence and morbidity of COPD varies widely among Hispanic American nations, with similar but limited findings among Hispanic subgroups in the U.S. Potential reasons for such variation include differences in racial ancestry and genetic susceptibility, exposure to tobacco smoke and/or biomass smoke, access to healthcare, and disease management. Future studies of COPD in Hispanics should include large samples of subgroups that are well-defined with regard to self-reported ethnicity, country of origin, area of residence, tobacco use, and socioeconomic status. Areas that need to be carefully examined include validation of COPD diagnoses for epidemiologic studies (e.g., by radiologic assessment), COPD in high-risk groups (e.g., Puerto Ricans), impact of biomass smoke (in rural areas) and air pollution (in urban areas) on COPD morbidity, effects of migration and acculturation on COPD prevalence and morbidity among Hispanic subgroups in the U.S., development of reference values for spirometry, smoking cessation, and overcoming barriers to management. Public health measures such as effective smoking prevention and cessation programs, reduction of air pollution and exposure to biomass smoke, and improved access to healthcare would help reduce the burden of COPD among Hispanics in the U.S. and Latin America.