help button home button
AJRCCM
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH
Published ahead of print on November 15, 2007, doi:10.1164/rccm.200708-1217PP

Am. J. Respir. Crit. Care Med., Volume 177, Number 3, February 2008, 248-252

A more recent version of this article appeared on February 1, 2008
This Article
Right arrow Full Text (PDF)
Right arrow All Versions of this Article:
200708-1217PPv1
177/3/248    most recent
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Panettieri, Jr., R. A
Right arrow Articles by Banks-Schlegel, S. P
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Panettieri, Jr., R. A
Right arrow Articles by Banks-Schlegel, S. P

Submitted on August 17, 2007
Accepted on November 15, 2007

Airway Smooth Muscle in Bronchial Tone, Inflammation and Remodeling: Basic to Clinical Relevance

Reynold A Panettieri, Jr.1, Michael I Kotlikoff2, William T Gerthoffer3, Marc B Hershenson4, Prescott G Woodruff5, Ian P Hall6, and Susan P Banks-Schlegel1*

1 Department of Medicine, University of Pennsylvania, Philadelphia, PA, USA, 2 Department of Biomedical Science, Cornell University College of Veterinary Medicine, Ithaca, NY, USA, 3 Department of Pharmacology, University of Nevada School of Medicine, Reno, NV, USA, 4 Department of Pediatrics, University of Michigan, Ann Arbor, MiI, USA, 5 Pulmonary and Critical Care Medicine, University of California, San Francisco, San Francisco, CA, USA, 6 Division of Therapeutics, University Hospital of Nottingham, Nottingham, United Kingdom

* To whom correspondence should be addressed. E-mail: schleges{at}nih.gov.

Airway smooth muscle (ASM) plays a pivotal role in modulating bronchomotor tone but also orchestrates and perpetuates airway inflammation and remodeling. Despite substantial research, there remain important unanswered questions. In 2006, the National Heart, Lung, and Blood Institute sponsored a workshop to define new directions in ASM biology. Important questions concerning the key functions of ASM include: Does developmental dysregulation of ASM function promote airway disease, what key signaling pathways in ASM evoke airway hyperresponsiveness in vivo, do alterations in ASM mass affect excitation-contraction coupling and can ASM modulate airway inflammation and remodeling in a physiologically relevant manner? This workshop identified critical issues in ASM biology to delineate areas for scientific investigation in the identification of new therapeutic and diagnostic approaches in asthma, chronic obstructive pulmonary disease (COPD) and cystic fibrosis.
Key words: Myocyte, signal transduction, force generation, migration, remodeling




This article has been cited by other articles:


Home page
 Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
D. Massaro and G. D. Massaro
Apoetm1Unc mice have impaired alveologenesis, low lung function, and rapid loss of lung function
Am J Physiol Lung Cell Mol Physiol, May 1, 2008; 294(5): L991 - L997.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH
Proc. Am. Thorac. Soc. Am. J. Respir. Cell Mol. Biol.
Copyright © 2007 American Thoracic Society 		  Solid Organ Transplant for the Intensivist 2008