help button home button
AJRCCM
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH
Published ahead of print on October 11, 2007, doi:10.1164/rccm.200704-541OC

Am. J. Respir. Crit. Care Med., Volume 177, Number 1, January 2008, 108-113

A more recent version of this article appeared on January 1, 2008
This Article
Right arrow Full Text (PDF)
Right arrow All Versions of this Article:
200704-541OCv1
177/1/108    most recent
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Sitbon, O.
Right arrow Articles by Simonneau, G.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Sitbon, O.
Right arrow Articles by Simonneau, G.

Submitted on April 5, 2007
Accepted on October 10, 2007

Prevalence of HIV-Related Pulmonary Arterial Hypertension in the Current Antiretroviral Therapy Era

Olivier Sitbon1*, Caroline Lascoux-Combe2, Jean-Francois Delfraissy3, Patrick G Yeni4, Francois Raffi5, Dominique De Zuttere6, Virginie Gressin7, Pierre Clerson8, Daniel Sereni2, and Gerald Simonneau1

1 Service de Pneumologie et Reanimation, Hopital Antoine Beclere, Clamart, France, 2 Service de Medecine Interne, Hopital Saint Louis, Paris, France, 3 Service de Medecine Interne, Hopital Bicetre, Le Kremlin Bicetre, France, 4 Service des Maladies Infectieuses et Tropicales A, Hopital Bichat, Paris, France, 5 CISIH, Hotel Dieu, Nantes, France, 6 Service de Medecine Interne, Hopital du Perpetuel Secours, Levallois Perret, France, 7 Actelion Pharmaceuticals France, Paris, France, 8 Orgametrie, Roubaix, France

* To whom correspondence should be addressed. E-mail: olivier.sitbon{at}abc.aphp.fr.

Rationale: The prevalence of HIV-associated pulmonary arterial hypertension has not been evaluated since introduction of combined highly active anti-retroviral treatments. Objective: To establish the current prevalence of pulmonary arterial hypertension in a large HIV-positive population. Methods: Prospective study conducted in 7,648 consecutive HIV-positive adults in 14 HIV clinics in France. Pulmonary arterial hypertension was identified through screening with a predefined algorithm. Patients with dyspnea unexplained by other causes underwent transthoracic Doppler echocardiography. Pulmonary arterial hypertension was suspected if peak velocity of tricuspid regurgitation was >2.5 m/s and was confirmed by right heart catheterization. Measurements and main results: Pulmonary arterial hypertension was diagnosed if mean pulmonary artery pressure was ≥ 25 mmHg at rest (with pulmonary capillary wedge pressure ≤15 mmHg) or ≥ 30 mmHg on exercise. 739 patients had dyspnea, of whom 312 had exclusion criteria, and 150 refused to participate. Among the remaining 277, 30 had known pulmonary arterial hypertension and 247 had unexplained dyspnea and underwent echocardiography; pulmonary arterial hypertension was suspected in 18 and confirmed in 5 to give a total of 35 cases. The prevalence was thus 0.46% [95% CI 0.32%-0.64%]. All new cases had relatively milder pulmonary arterial hypertension. Conclusions: The prevalence of HIV-associated pulmonary arterial hypertension is about the same as in the early 1990s. Given the current good long-term prognosis of HIV patients, the severity of pulmonary arterial hypertension in HIV-infected patients and the absence of predictive factors, careful screening for pulmonary arterial hypertension is warranted for patients with unexplained dyspnea.
Key words: Hypertension, pulmonary, HIV infection, epidemiologic studies, dyspnea, echocardiography, Doppler, prevalence




This article has been cited by other articles:


Home page
 Eur Heart JHome page
Authors/Task Force Members, N. Galie, M. M. Hoeper, M. Humbert, A. Torbicki, J.-L. Vachiery, J. A. Barbera, M. Beghetti, P. Corris, S. Gaine, et al.
Guidelines for the diagnosis and treatment of pulmonary hypertension: The Task Force for the Diagnosis and Treatment of Pulmonary Hypertension of the European Society of Cardiology (ESC) and the European Respiratory Society (ERS), endorsed by the International Society of Heart and Lung Transplantation (ISHLT)
Eur. Heart J., October 2, 2009; 30(20): 2493 - 2537.
[Full Text] [PDF]

Home page
 Eur Respir JHome page
A. Barnier, I. Frachon, J. Dewilde, C. Gut-Gobert, Y. Jobic, and C. Leroyer
Improvement of HIV-related pulmonary hypertension after the introduction of an antiretroviral therapy
Eur. Respir. J., July 1, 2009; 34(1): 277 - 278.
[Full Text] [PDF]

Home page
 J Am Coll CardiolHome page
P. M. Hassoun, L. Mouthon, J. A. Barbera, S. Eddahibi, S. C. Flores, F. Grimminger, P. L. Jones, M. L. Maitland, E. D. Michelakis, N. W. Morrell, et al.
Inflammation, growth factors, and pulmonary vascular remodeling.
J. Am. Coll. Cardiol., June 30, 2009; 54(1 Suppl): S10 - S19.
[Abstract] [Full Text] [PDF]

Home page
 J Am Coll CardiolHome page
G. Simonneau, I. M. Robbins, M. Beghetti, R. N. Channick, M. Delcroix, C. P. Denton, C. G. Elliott, S. P. Gaine, M. T. Gladwin, Z.-C. Jing, et al.
Updated clinical classification of pulmonary hypertension.
J. Am. Coll. Cardiol., June 30, 2009; 54(1 Suppl): S43 - S54.
[Abstract] [Full Text] [PDF]

Home page
 J Am Coll CardiolHome page
D. B. Badesch, H. C. Champion, M. A. Gomez Sanchez, M. M. Hoeper, J. E. Loyd, A. Manes, M. McGoon, R. Naeije, H. Olschewski, R. J. Oudiz, et al.
Diagnosis and assessment of pulmonary arterial hypertension.
J. Am. Coll. Cardiol., June 30, 2009; 54(1 Suppl): S55 - S66.
[Abstract] [Full Text] [PDF]

Home page
 J Am Coll CardiolHome page
V. V. McLaughlin, S. L. Archer, D. B. Badesch, R. J. Barst, H. W. Farber, J. R. Lindner, M. A. Mathier, M. D. McGoon, M. H. Park, R. S. Rosenson, et al.
ACCF/AHA 2009 Expert Consensus Document on Pulmonary Hypertension: A Report of the American College of Cardiology Foundation Task Force on Expert Consensus Documents and the American Heart Association Developed in Collaboration With the American College of Chest Physicians; American Thoracic Society, Inc.; and the Pulmonary Hypertension Association
J. Am. Coll. Cardiol., April 28, 2009; 53(17): 1573 - 1619.
[Full Text] [PDF]

Home page
 CirculationHome page
Writing Committee Members, V. V. McLaughlin, S. L. Archer, D. B. Badesch, R. J. Barst, H. W. Farber, J. R. Lindner, M. A. Mathier, M. D. McGoon, M. H. Park, et al.
ACCF/AHA 2009 Expert Consensus Document on Pulmonary Hypertension: A Report of the American College of Cardiology Foundation Task Force on Expert Consensus Documents and the American Heart Association: Developed in Collaboration With the American College of Chest Physicians, American Thoracic Society, Inc., and the Pulmonary Hypertension Association
Circulation, April 28, 2009; 119(16): 2250 - 2294.
[Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
M. Humbert
Update in Pulmonary Hypertension 2008
Am. J. Respir. Crit. Care Med., April 15, 2009; 179(8): 650 - 656.
[Full Text] [PDF]

Home page
 CirculationHome page
M. Lapa, B. Dias, C. Jardim, C. J.C. Fernandes, P. M.M. Dourado, M. Figueiredo, A. Farias, J. Tsutsui, M. Terra-Filho, M. Humbert, et al.
Cardiopulmonary Manifestations of Hepatosplenic Schistosomiasis
Circulation, March 24, 2009; 119(11): 1518 - 1523.
[Abstract] [Full Text] [PDF]

Home page
 ERRHome page
R. Souza and C. Jardim
Trends in pulmonary arterial hypertension
Eur. Respir. Rev., March 1, 2009; 18(111): 7 - 12.
[Full Text] [PDF]

Home page
 Eur Respir JHome page
B. Degano, A. Yaici, J. Le Pavec, L. Savale, X. Jais, B. Camara, M. Humbert, G. Simonneau, and O. Sitbon
Long-term effects of bosentan in patients with HIV-associated pulmonary arterial hypertension
Eur. Respir. J., January 1, 2009; 33(1): 92 - 98.
[Abstract] [Full Text] [PDF]

Home page
 ESC Textbook of Cardiovascular MedicineHome page
N. Galiè and A. Manes
CHAPTER 24 Pulmonary Hypertension
ESC Textbook of Cardiovascular Medicine, January 1, 2009; 2(1): med-9780199566990-chapter - med-9780199566990-chapter.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
M. Humbert
Update in Pulmonary Arterial Hypertension 2007
Am. J. Respir. Crit. Care Med., March 15, 2008; 177(6): 574 - 579.
[Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH
Proc. Am. Thorac. Soc. Am. J. Respir. Cell Mol. Biol.
Copyright © 2007 American Thoracic Society 		  CCM abstracts