Published ahead of print on October 11, 2007, doi:10.1164/rccm.200704-541OC Am. J. Respir. Crit. Care Med., Volume 177, Number 1, January 2008, 108-113 A more recent version of this article appeared on January 1, 2008
Submitted on April 5, 2007 Prevalence of HIV-Related Pulmonary Arterial Hypertension in the Current Antiretroviral Therapy EraOlivier Sitbon1*,1 Service de Pneumologie et Reanimation, Hopital Antoine Beclere, Clamart, France, 2 Service de Medecine Interne, Hopital Saint Louis, Paris, France, 3 Service de Medecine Interne, Hopital Bicetre, Le Kremlin Bicetre, France, 4 Service des Maladies Infectieuses et Tropicales A, Hopital Bichat, Paris, France, 5 CISIH, Hotel Dieu, Nantes, France, 6 Service de Medecine Interne, Hopital du Perpetuel Secours, Levallois Perret, France, 7 Actelion Pharmaceuticals France, Paris, France, 8 Orgametrie, Roubaix, France * To whom correspondence should be addressed. E-mail: olivier.sitbon{at}abc.aphp.fr.
Rationale: The prevalence of HIV-associated pulmonary arterial hypertension has not been evaluated since introduction of combined highly active anti-retroviral treatments. Objective: To establish the current prevalence of pulmonary arterial hypertension in a large HIV-positive population. Methods: Prospective study conducted in 7,648 consecutive HIV-positive adults in 14 HIV clinics in France. Pulmonary arterial hypertension was identified through screening with a predefined algorithm. Patients with dyspnea unexplained by other causes underwent transthoracic Doppler echocardiography. Pulmonary arterial hypertension was suspected if peak velocity of tricuspid regurgitation was >2.5 m/s and was confirmed by right heart catheterization. Measurements and main results: Pulmonary arterial hypertension was diagnosed if mean pulmonary artery pressure was Key words: Hypertension, pulmonary, HIV infection, epidemiologic studies, dyspnea, echocardiography, Doppler, prevalence
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