Rationale: The intermittent hypoxia (IH) that characterizes sleep-disordered breathing (SDB), impairs spatial learning and increases NADPH oxidase activity and oxidative stress in rodents. We hypothesized that green tea catechin polyphenols (GTP) may attenuate IH-induced neurobehavioral deficits by reducing IH-induced NADPH oxidase expression, lipid peroxidation and inflammation. Objectives: To assess the effects of GTP administered in drinking water on the cognitive, inflammatory, and oxidative responses to long term (>14 days) IH during sleep in male Sprague-Dawley rats. Methods & Measurements: Cognitive assessments were conducted in the Morris water maze (MWM). We measured levels and expression of malondialdehyde (MDA), Prostaglandin E₂ (PGE₂), p47^phox sub-unit of NADPH oxidase, receptor for advanced glycation end products (RAGE), and glial fibrillary acidic protein (GFAP) expression in rodent brain tissue. Main Results: GTP treatment prevented IH-induced decreases in spatial bias for the hidden platform during the MWM probe trails, as well as IH-induced increases p47phox expression within the hippocampal CA1 region. In untreated animals, IH exposure was associated with doubling of cortical MDA levels in comparison to room air controls, while GTP-treated animals exposed to IH showed a 40% reduction in MDA levels. Increases in brain RAGE and GFAP expression were observed in IH exposed animals, and these increases were attenuated in animals treated with GTP. Conclusions: Thus, oral GTP attenuates IH-induced spatial learning deficits and mitigates IH-induced oxidative stress through multiple beneficial effects on oxidant pathways. Since oxidative processes underlie neurocognitive deficits associated with IH, the potential therapeutic role of GTP in SDB deserves further exploration.