help button home button
AJRCCM
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH
Published ahead of print on February 1, 2007, doi:10.1164/rccm.200611-1598OC

Am. J. Respir. Crit. Care Med., Volume 175, Number 11, June 2007, 1186-1191

A more recent version of this article appeared on June 1, 2007
This Article
Right arrow Full Text (PDF)
Right arrow All Versions of this Article:
200611-1598OCv1
175/11/1186    most recent
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by El Solh, A. A
Right arrow Articles by Mankowski, C. R
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by El Solh, A. A
Right arrow Articles by Mankowski, C. R

Submitted on November 6, 2006
Accepted on February 1, 2007

Endothelial Cell Apoptosis in Obstructive Sleep Apnea: A Link to Endothelial Dysfunction

Ali A El Solh1*, Morohunfolu E Akinnusi1, Fadi H Baddoura2, and Corey R Mankowski1

1 Western New York Respiratory Research Center, Department of Medicine, Division of Pulmonary, Critical Care, and Sleep Medicine, University at Buffalo School of Medicine and Biomedical Sciences and the Veterans Affairs Medical Center, Buffalo, NY, USA, 2 Department of Pathology, University at Buffalo School of Medicine and Biomedical Sciences and the Veterans Affairs Medical Center, Buffalo, NY, USA

* To whom correspondence should be addressed. E-mail: solh{at}buffalo.edu.

Rationale: Patients with obstructive sleep apnea (OSA) are at increased risk for cardiovascular diseases. Injury of endothelial cells has been advanced as an initial trigger to atherosclerosis. Objective: To study the association between circulating apoptotic endothelial cells and vasomotor dysfunction as a function of sleep apnea. Methods: Brachial artery flow-mediated dilation was determined in 14 subjects with documented OSA and 10 healthy control subjects at baseline and 8 weeks post continuous positive airway pressure therapy (CPAP) . Quantification of circulating apoptotic endothelial cells (CD146+ Annexin V+) was performed by flow cytometry. Measurements and Main Results: Compared with healthy subjects, patients with OSA had higher numbers of circulating CD146+ Annexin V+ cells (39.2±13.6 cells/mL and 17.8±9.4, respectively; p<0.001). Increased apoptotic endothelial cells correlated moderately with abnormal vascular function (r= -0.61; p=0.001). A significant correlation was also observed between CD146 Annexin V+ cells and the apnea hypopnea index (r= 0.56; p=0.004). Following 8 weeks treatment with CPAP, the numbers of circulating apoptotic endothelial cells were reduced significantly from 39.2±13.6 to 22.3±12.9 apoptotic cells per ml (p<0.001) and correlated with improvement in endothelium-dependent vasodilation (r=0.49; p=0.07). Conclusions: In patients with OSA, impairment of endothelial-dependent vasodilation correlated with the degree of endothelial cell apoptosis. CPAP therapy led to significant decline in circulating apoptotic endothelial cells. These findings provide an additional mechanism for the predisposition of OSA patients to premature vascular disease.
Key words: sleep apnea, endothelium, apoptosis, vasodilation




This article has been cited by other articles:


Home page
 Am. J. Respir. Crit. Care Med.Home page
M. Kohler, S. Craig, D. Nicoll, P. Leeson, R. J. O. Davies, and J. R. Stradling
Endothelial Function and Arterial Stiffness in Minimally Symptomatic Obstructive Sleep Apnea
Am. J. Respir. Crit. Care Med., November 1, 2008; 178(9): 984 - 988.
[Abstract] [Full Text] [PDF]

Home page
 Eur Respir JHome page
P. Levy, J-L. Pepin, C. Arnaud, R. Tamisier, J-C. Borel, M. Dematteis, D. Godin-Ribuot, and C. Ribuot
Intermittent hypoxia and sleep-disordered breathing: current concepts and perspectives
Eur. Respir. J., October 1, 2008; 32(4): 1082 - 1095.
[Abstract] [Full Text] [PDF]

Home page
 CirculationHome page
V. K. Somers, D. P. White, R. Amin, W. T. Abraham, F. Costa, A. Culebras, S. Daniels, J. S. Floras, C. E. Hunt, L. J. Olson, et al.
Sleep Apnea and Cardiovascular Disease: An American Heart Association/American College of Cardiology Foundation Scientific Statement From the American Heart Association Council for High Blood Pressure Research Professional Education Committee, Council on Clinical Cardiology, Stroke Council, and Council on Cardiovascular Nursing In Collaboration With the National Heart, Lung, and Blood Institute National Center on Sleep Disorders Research (National Institutes of Health)
Circulation, September 2, 2008; 118(10): 1080 - 1111.
[Full Text] [PDF]

Home page
 CirculationHome page
F. Valham, T. Mooe, T. Rabben, H. Stenlund, U. Wiklund, and K. A. Franklin
Increased Risk of Stroke in Patients With Coronary Artery Disease and Sleep Apnea: A 10-Year Follow-Up
Circulation, August 26, 2008; 118(9): 955 - 960.
[Abstract] [Full Text] [PDF]

Home page
 J Am Coll CardiolHome page
V. K. Somers, D. P. White, R. Amin, W. T. Abraham, F. Costa, A. Culebras, S. Daniels, J. S. Floras, C. E. Hunt, L. J. Olson, et al.
Sleep Apnea and Cardiovascular Disease: An American Heart Association/American College of Cardiology Foundation Scientific Statement From the American Heart Association Council for High Blood Pressure Research Professional Education Committee, Council on Clinical Cardiology, Stroke Council, and Council on Cardiovascular Nursing In Collaboration With the National Heart, Lung, and Blood Institute National Center on Sleep Disorders Research (National Institutes of Health)
J. Am. Coll. Cardiol., August 19, 2008; 52(8): 686 - 717.
[Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
R. L. Horner and T. D. Bradley
Update in Sleep and Control of Ventilation 2007
Am. J. Respir. Crit. Care Med., May 1, 2008; 177(9): 947 - 951.
[Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
D. Gozal and L. Kheirandish-Gozal
Cardiovascular Morbidity in Obstructive Sleep Apnea: Oxidative Stress, Inflammation, and Much More
Am. J. Respir. Crit. Care Med., February 15, 2008; 177(4): 369 - 375.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
M. Dematteis, C. Julien, C. Guillermet, N. Sturm, S. Lantuejoul, M. Mallaret, P. Levy, and E. Gozal
Intermittent Hypoxia Induces Early Functional Cardiovascular Remodeling in Mice
Am. J. Respir. Crit. Care Med., January 15, 2008; 177(2): 227 - 235.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
P. K. Y. Goon, T. Watson, and G. Y. H. Lip
Circulating Endothelial Cells in Obstructive Sleep Apnea: An Important Methodological Lesson
Am. J. Respir. Crit. Care Med., June 15, 2007; 175(12): 1346 - 1346.
[Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
A. El Solh
Role of CD146 in Detection of Apoptotic Circulating Endothelial Cells in Obstructive Sleep Apnea
Am. J. Respir. Crit. Care Med., June 15, 2007; 175(12): 1347 - 1347.
[Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
A. Tzouvelekis, I. Kotsianidis, P. Steiropoulos, and D. Bouros
Role of CD146 in Detection of Apoptotic Circulating Endothelial Cells in Obstructive Sleep Apnea
Am. J. Respir. Crit. Care Med., June 15, 2007; 175(12): 1346a - 1347.
[Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH
Proc. Am. Thorac. Soc. Am. J. Respir. Cell Mol. Biol.
Copyright © 2007 American Thoracic Society 		  ATS State of the Art Course 2008