Rationale: Aerobic conditioning improves exercise capacity and decreases symptoms in asthmatic patients. However, its benefits on allergic airway inflammation are poorly understood. Objectives: To evaluate the effects of two intensities of aerobic exercise on airway inflammation and remodeling in a model of chronic allergic lung inflammation. Methods: Mice were submitted to a chronic ovalbumin (OVA) sensitization and to 4-weeks low (OVA+Low) or moderate (OVA+Mod) exercise training in treadmill. Airway inflammation and remodeling and expression of Th1 and Th2 cytokines were evaluated. Results: OVA-induced allergic airway inflammation and remodeling characterized by an increase in collagen (288%), elastic (56%), smooth muscle (380%) and epithelial (402%) contents (p<0.001) when compared with the Control group. OVA+Low and OVA+Mod groups presented a decrease of BALF eosinophils (respectively, 84% and 75%, p<0.01) and airway walls (respectively, 94% and 58%, p<0.001) when compared with the OVA group. OVA+Low and OVA+Mod groups also presented a reduction in the number of peribronchial inflammatory cells expressing interleukin 4 (IL-4) (respectively, 85% and 75%; p<0.01) and IL-5 (respectively, 88% and 89%; p<0.01) when compared with the OVA group. Aerobic conditioning did not change either the expression of interferon-gamma and IL-2 by inflammatory cells or plasma levels of IgE or IgG₁. OVA+Low and OVA+Mod presented an increase in the expression of IL-10 (p<0.001). Low and moderate aerobic conditioning also reduced airway remodeling in OVA-sensitized mice when compared with the OVA group. Conclusions: We concluded that low and moderate aerobic exercises decrease airway inflammation and remodeling in a murine model of asthma.