Published ahead of print on August 9, 2007, doi:10.1164/rccm.200610-1507OC Am. J. Respir. Crit. Care Med., Volume 176, Number 9, November 2007, 843-848 A more recent version of this article appeared on November 1, 2007
Submitted on October 19, 2006 Effect of Breastfeeding on Lung Function in Childhood and Modulation by Maternal Asthma and AtopyTheresa W Guilbert1*,1 Department of Pediatrics, University of Arizona, Arizona Respiratory Center, Tucson, AZ, USA; Department of Pediatrics, University of Wisconsin-Madison, Madison, WI, USA, 2 Department of Pediatrics, University of Arizona, Arizona Respiratory Center, Tucson, AZ, USA * To whom correspondence should be addressed. E-mail: tguilbert{at}wisc.edu.
Rationale. The protective effect of breast-feeding on early respiratory infections is well established, but its relationship to the development of subsequent asthma remains controversial. To clarify these complex issues, we examined the association between lung function and infant feeding practices. Methods. In the Tucson Children's Respiratory Study (CRS), feeding practices were assessed prospectively based on questionnaires completed at enrollment and well child visits. Formula introduction was categorized as having occurred before 2 months (n=143, "early formula introduction", between 2 to <4 months (n=336), or at Key words: Breastfeeding; formula feeding; lung function; epidemiology; lower respiratory tract infections;
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