help button home button
AJRCCM
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH
Published ahead of print on January 11, 2007, doi:10.1164/rccm.200608-1088OC

Am. J. Respir. Crit. Care Med., Volume 175, Number 7, April 2007, 737-742

A more recent version of this article appeared on April 1, 2007
This Article
Right arrow Full Text (PDF)
Right arrow All Versions of this Article:
200608-1088OCv1
175/7/737    most recent
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Luetkemeyer, A. F
Right arrow Articles by Havlir, D. V
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Luetkemeyer, A. F
Right arrow Articles by Havlir, D. V

Submitted on August 3, 2006
Accepted on January 11, 2007

Comparison of an Interferon-{gamma} Release Assay to Tuberculin Skin Testing in HIV-Infected Individuals

Annie F Luetkemeyer1*, Edwin D Charlebois2, Laura L Flores3, David R Bangsberg4, Steven G Deeks5, Jeffrey N Martin5, and Diane V Havlir5

1 HIV/AIDS Division, San Francisco General Hospital, University of California at San Francisco, San Francisco, CA, USA; Center for AIDS Prevention Studies, University of California at San Francisco, San Francisco, CA, USA, 2 Center for AIDS Prevention Studies, University of California at San Francisco, San Francisco, CA, USA, 3 Division of Pulmonary and Critical Care, San Francisco Hospital, University of California at San Francisco, San Francisco, CA, USA, 4 HIV/AIDS Division, San Francisco General Hospital, University of California at San Francisco, San Francisco, CA, USA; Epidemiology and Prevention Interventions Center, University of California at San Francisco, San Francisco, CA, USA, 5 HIV/AIDS Division, San Francisco General Hospital, University of California at San Francisco, San Francisco, CA, USA

* To whom correspondence should be addressed. E-mail: aluetkemeyer{at}php.ucsf.edu.

Rationale: Although interferon-gamma (IFN-{gamma}) release assays are approved for the diagnosis of latent tuberculosis infection (LTBI), limited data exist regarding their performance in HIV infection. Objectives: To compare tuberculin skin test (TST) results to the commercial IFN-{gamma} release assay QuantiFERON®-TB Gold In-Tube (QFT) for the diagnosis of LTBI in HIV-infected adults. Methods: 294 HIV-infected subjects sampled from two San Francisco cohorts underwent TST, using 5 TU of purified protein derivative, and QFT, measuring IFN-{gamma} response to M. tuberculosis specific RD-1 antigens. Main Results: Of 294 participants, 205 (70%) returned for an evaluable TST. Concordance between QFT and TST was 89.3% (kappa = 0.37, p = 0.007). However, in subjects with positive tests results by either TST or QFT, only 28% (8/29) had positive test results by both modalities. TST positive/QFT negative discordant results were found in 5.1% of subjects and TST negative/QFT positive discordance in 5.6%. Indeterminate QFT results occurred in 5.1%, all due to a failure to respond to the phytohemagglutinin positive control. Subjects with a CD4+ count of < 100 cells/mm3 had a RR of an indeterminate result of 4.24 (95% CI 1.55- 11.61, p= 0.003) compared to those with CD4+≥ 100. Conclusions: Overall concordance between QFT and TST in HIV infection was high, but agreement among subjects with positive tests by either modality was low.
Key words: latent tuberculosis infection, Human Immunodeficiency Virus, QuantiFERON, Interferon-{gamma} assay, tuberculin skin test




This article has been cited by other articles:


Home page
 Br Med BullHome page
A. Lalvani and M. Pareek
A 100 year update on diagnosis of tuberculosis infection
Br. Med. Bull., November 18, 2009; (2009) ldp039v1.
[Abstract] [Full Text] [PDF]

Home page
 Am J Clin PatholHome page
X. Zhao, D. Mazlagic, E. A. Flynn, H. Hernandez, and C. L. Abbott
Is the QuantiFERON-TB Blood Assay a Good Replacement for the Tuberculin Skin Test in Tuberculosis Screening?: A Pilot Study at Berkshire Medical Center
Am J Clin Pathol, November 1, 2009; 132(5): 678 - 686.
[Abstract] [Full Text] [PDF]

Home page
 Nephrol Dial TransplantHome page
T. Inoue, T. Nakamura, A. Katsuma, S. Masumoto, E. Minami, D. Katagiri, T. Hoshino, M. Shibata, M. Tada, and F. Hinoshita
The value of QuantiFERON(R)TB-Gold in the diagnosis of tuberculosis among dialysis patients
Nephrol. Dial. Transplant., July 1, 2009; 24(7): 2252 - 2257.
[Abstract] [Full Text] [PDF]

Home page
 ChestHome page
L. Richeldi, M. Losi, R. D'Amico, M. Luppi, A. Ferrari, C. Mussini, M. Codeluppi, S. Cocchi, F. Prati, V. Paci, et al.
Performance of Tests for Latent Tuberculosis in Different Groups of Immunocompromised Patients
Chest, July 1, 2009; 136(1): 198 - 204.
[Abstract] [Full Text] [PDF]

Home page
 Eur Respir JHome page
U. Mack, G. B. Migliori, M. Sester, H. L. Rieder, S. Ehlers, D. Goletti, A. Bossink, K. Magdorf, C. Holscher, B. Kampmann, et al.
LTBI: latent tuberculosis infection or lasting immune responses to M. tuberculosis? A TBNET consensus statement
Eur. Respir. J., May 1, 2009; 33(5): 956 - 973.
[Abstract] [Full Text] [PDF]

Home page
 Eur Respir JHome page
M. Ruhwald, T. Bodmer, C. Maier, M. Jepsen, M. B. Haaland, J. Eugen-Olsen, P. Ravn, and on behalf of TBNET
Evaluating the potential of IP-10 and MCP-2 as biomarkers for the diagnosis of tuberculosis
Eur. Respir. J., December 1, 2008; 32(6): 1607 - 1615.
[Abstract] [Full Text] [PDF]

Home page
 Eur Respir JHome page
G. H. Bothamley, L. Ditiu, G. B. Migliori, C. Lange, and TBNET contributors
Active case finding of tuberculosis in Europe: a Tuberculosis Network European Trials Group (TBNET) survey
Eur. Respir. J., October 1, 2008; 32(4): 1023 - 1030.
[Abstract] [Full Text] [PDF]

Home page
 ChestHome page
J. C. Choi, J. W. Shin, J. Y. Kim, I. W. Park, B. W. Choi, and M.-K. Lee
The Effect of Previous Tuberculin Skin Test on the Follow-up Examination of Whole-Blood Interferon-{gamma} Assay in the Screening for Latent Tuberculosis Infection
Chest, June 1, 2008; 133(6): 1415 - 1420.
[Abstract] [Full Text] [PDF]

Home page
 ChestHome page
Y. Kobashi, K. Mouri, S. Yagi, Y. Obase, N. Miyashita, N. Okimoto, T. Matsushima, T. Kageoka, and M. Oka
Clinical Utility of the QuantiFERON TB-2G Test for Elderly Patients With Active Tuberculosis
Chest, May 1, 2008; 133(5): 1196 - 1202.
[Abstract] [Full Text] [PDF]

Home page
 GutHome page
N Viget, G Vernier-Massouille, D Salmon-Ceron, Y Yazdanpanah, and J-F Colombel
Opportunistic infections in patients with inflammatory bowel disease: prevention and diagnosis
Gut, April 1, 2008; 57(4): 549 - 558.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
W. W. Yew and C. C. Leung
Update in Tuberculosis 2007
Am. J. Respir. Crit. Care Med., March 1, 2008; 177(5): 479 - 485.
[Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH
Proc. Am. Thorac. Soc. Am. J. Respir. Cell Mol. Biol.
Copyright © 2007 American Thoracic Society 		  New Orleans Int'l Conf