help button home button
AJRCCM
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH

Published ahead of print on July 12, 2007, doi:10.1164/rccm.200605-730OC

Am. J. Respir. Crit. Care Med., Volume 176, Number 10, November 2007, 994-1000

A more recent version of this article appeared on November 15, 2007
This Article
Right arrow Full Text (PDF)
Right arrow All Versions of this Article:
200605-730OCv1
176/10/994    most recent
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Harber, P. I
Right arrow Articles by Connett, J.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Harber, P. I
Right arrow Articles by Connett, J.

Submitted on May 31, 2006
Accepted on July 12, 2007

Effect of Occupational Exposures on Decline of Lung Function in Early COPD

Philip I Harber1*, Donald P Tashkin2, Michael Simmons1, Lori Crawford1, Eva Hnizdo3, and John Connett4

1 Division of Occupational and Environmental Medicine, Department of Family Medicine, University of California Los Angeles, Los Angeles, CA, United States, 2 Division of Pulmonary and Critical Care Medicine, Department of Medicine, University of California Los Angeles, Los Angeles, CA, USA, 3 Division of Respiratory Disease Studies, National Institute for Occupational Safety and Health, Morgantown, WV, USA, 4 Division of Biostatistics, School of Public Health, University of Minnesota, Minneapolis, MN, USA

* To whom correspondence should be addressed. E-mail: pharber{at}mednet.ucla.edu.

Rationale: Several occupational exposures adversely affect lung function. Objectives: This study reports the influence of continued occupational dust and fume exposures on the rate of decline of lung function in participants with early COPD studied in a population-based study. Methods: Participants were 5724 participants in the Lung Health Study (LHS), a multi-center study of smoking cessation and anticholinergic bronchodilator administration in smokers with early COPD (3592 men, 2132 women); average post-bronchodilator FEV1 at entry was 78.4% predicted for men and 78.2% predicted for women; all participants had FEV1/FVC ratio < 0.70. Measurements: Participants underwent a baseline evaluation and five annual follow-up assessments including questionnaires and spirometry. Main Results: The effect of ongoing dust or fume exposure upon FEV1 in each follow-up year was statistically evaluated with a mixed effects regression model which adjusted for FEV1 at entry, age, airway responsiveness to methacholine, baseline smoking intensity, and for time varying (yearly) smoking status during each follow-up year. In men with early COPD, each year of continued fume exposure was associated with a 0.25% predicted reduction in postbronchodilator % predicted FEV1. Continued smoking and airway hyperresponsiveness were also associated with reduction in FEV1 during each year of follow-up in both men and women. Statistically significant effects of dust exposure on the rate of decline were not found, nor were effects of fume exposure noted in women. Conclusions: These results suggest a need for secondary prevention by controlling occupational fume exposures.


Key words: Pulmonary Disease, Chronic Obstructive; Longitudinal Studies; Fume; Occupational Exposure




This article has been cited by other articles:


Home page
Occup. Environ. Med.Home page
J E Hart, F Laden, E A Eisen, T J Smith, and E Garshick
Chronic obstructive pulmonary disease mortality in railroad workers
Occup. Environ. Med., April 1, 2009; 66(4): 221 - 226.
[Abstract] [Full Text] [PDF]


Home page
ThoraxHome page
M. S Jaakkola
Smoke and dust get in your eyes: what does it mean in the workplace?
Thorax, January 1, 2009; 64(1): 1 - 2.
[Full Text] [PDF]


Home page
ThoraxHome page
P D Blanc, C Iribarren, L Trupin, G Earnest, P P Katz, J Balmes, S Sidney, and M D Eisner
Occupational exposures and the risk of COPD: dusty trades revisited
Thorax, January 1, 2009; 64(1): 6 - 12.
[Abstract] [Full Text] [PDF]


Home page
ChestHome page
E. Rodriguez, J. Ferrer, S. Marti, J.-P. Zock, E. Plana, and F. Morell
Impact of Occupational Exposure on Severity of COPD
Chest, December 1, 2008; 134(6): 1237 - 1243.
[Abstract] [Full Text] [PDF]


Home page
Proc Am Thorac SocHome page
D. S. Wilkes
Clinical Year in Review III: Idiopathic Pulmonary Fibrosis, Occupational Medicine, and Lung Transplantation
Proceedings of the ATS, September 15, 2008; 5(7): 751 - 754.
[Full Text] [PDF]


Home page
Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
J. L. Wright, M. Cosio, and A. Churg
Animal models of chronic obstructive pulmonary disease
Am J Physiol Lung Cell Mol Physiol, July 1, 2008; 295(1): L1 - L15.
[Abstract] [Full Text] [PDF]


Home page
Am. J. Respir. Crit. Care Med.Home page
E. Whitney
Effects of Misclassification of Fume Exposure
Am. J. Respir. Crit. Care Med., May 15, 2008; 177(10): 1172 - 1172.
[Full Text] [PDF]


Home page
Am. J. Respir. Crit. Care Med.Home page
P. Harber, D. Tashkin, and E. Hnizdo
Effects of Misclassification of Fume Exposure
Am. J. Respir. Crit. Care Med., May 15, 2008; 177(10): 1172 - 1172.
[Full Text] [PDF]


Home page
Am. J. Respir. Crit. Care Med.Home page
W. MacNee
Update in Chronic Obstructive Pulmonary Disease 2007
Am. J. Respir. Crit. Care Med., April 15, 2008; 177(8): 820 - 829.
[Full Text] [PDF]


Home page
Am. J. Respir. Crit. Care Med.Home page
T. S. Nawrot, E. Alfaro-Moreno, and B. Nemery
Update in Occupational and Environmental Respiratory Disease 2007
Am. J. Respir. Crit. Care Med., April 1, 2008; 177(7): 696 - 700.
[Full Text] [PDF]


Home page
Am. J. Respir. Crit. Care Med.Home page
K. Toren and J. Balmes
Chronic Obstructive Pulmonary Disease: Does Occupation Matter?
Am. J. Respir. Crit. Care Med., November 15, 2007; 176(10): 951 - 952.
[Full Text] [PDF]




HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH
Proc. Am. Thorac. Soc. Am. J. Respir. Cell Mol. Biol.
Copyright © 2007 American Thoracic Society
  ATS Quiz on Sleep Study Tracings