help button home button
AJRCCM
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH
Published ahead of print on September 28, 2006, doi:10.1164/rccm.200604-489OC

Am. J. Respir. Crit. Care Med., Volume 174, Number 12, December 2006, 1392-1399

A more recent version of this article appeared on December 15, 2006
This Article
Right arrow Full Text (PDF)
Right arrow All Versions of this Article:
200604-489OCv1
174/12/1392    most recent
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Kaiser, L.
Right arrow Articles by Soccal, P. M
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Kaiser, L.
Right arrow Articles by Soccal, P. M

Submitted on April 7, 2006
Accepted on September 26, 2006

Chronic Rhinoviral Infection in Lung Transplant Recipients

Laurent Kaiser1*, John-David Aubert2, Jean-Claude Pache3, Christelle Deffernez1, Thierry Rochat4, Jorge Garbino5, Werner Wunderli1, Pascal Meylan6, Sabine Yerly1, Luc Perrin1, Igor Letovanec7, Laurent Nicod8, Caroline Tapparel1, and Paola M Soccal9

1 Central Laboratory of Virology, Division of Infectious Diseases, Department of Internal Medicine, University Hospitals of Geneva, Genevea, Switzerland, 2 Division of Pulmonary Medicine, Department of Medicine, University Hospital of Lausanne, Lausanne, Switzerland, 3 Department of Pathology, University Hospitals of Geneva, Geneva, Switzerland, 4 Division of Pulmonary Medicine, Department of Internal Medicine, University Hospitals of Geneva, Geneva, Switzerland, 5 Division of Infectious Diseases, Department of Internal Medicine, University Hospitals of Geneva, Geneva, Switzerland, 6 Institute of Microbiology and Division of Infectious Diseases, University Hospital of Lausanne, Lausanne, Switzerland, 7 Department of Pathology, University Hospital of Lausanne, Lausanne, Switzerland, 8 Division of Pulmonary Medicine, University Hospital, Bern, Switzerland, 9 Institute of Microbiology and Division of Infectious Diseases, University Hospital of Lausanne, Lausanne, Switzerland; Division of Pulmonary Medicine, University Hospital, Bern, Switzerland; Clinic of Thoracic Surgery, Department of Surgery, University Hospitals of Geneva, Geneva, Switzerland

* To whom correspondence should be addressed. E-mail: laurent.kaiser{at}hcuge.ch.

Rationale: Lung transplant recipients are particularly at risk of complications from rhinovirus, the most frequent respiratory virus circulating in the community. Objectives: To determine whether lung transplant recipients can be chronically infected by rhinovirus and the potential clinical impact. Methods: We first identified an index case in which rhinovirus was isolated repeatedly and conducted detailed molecular analysis to determine whether this was related to a unique strain or to re-infection episodes. Transbronchial biopsies were used to assess the presence of rhinovirus in the lung parenchyma. The incidence of chronic rhinoviral infections and potential clinical impact was assessed prospectively in a cohort of 68 lung transplant recipients during 19 months by screening of bronchoalveolar lavages (BAL). Measurements and Main Results: We describe three lung transplant recipients with graft dysfunctions in whom rhinovirus was identified by RT-PCR in upper and lower respiratory specimens over a 12-month period. In two cases, rhinovirus was repeatedly isolated in culture. The persistence of a unique strain in each case was confirmed by sequence analysis of the 5'NCR and VP1 gene. In the index case, rhinovirus was detected in the lower respiratory parenchyma. In the cohort of lung transplant recipients, rhinoviral infections were documented in BAL specimens of 10 recipients and two presented with a persistent infection. Conclusions: Rhinoviral infection can be persistent in lung transplant recipients with graft dysfunction and the virus can be detected in the lung parenchyma. Given the potential clinical impact, chronic rhinoviral infection needs to be considered in lung transplant recipients.
Key words: rhinovirus, respiratory virus, lung transplantation, VP1, picornavirus




This article has been cited by other articles:


Home page
 ThoraxHome page
J Garbino, P M Soccal, J-D Aubert, T Rochat, P Meylan, Y Thomas, C Tapparel, P-O Bridevaux, and L Kaiser
Respiratory viruses in bronchoalveolar lavage: a hospital-based cohort study in adults
Thorax, May 1, 2009; 64(5): 399 - 404.
[Abstract] [Full Text] [PDF]

Home page
 Proc Am Thorac SocHome page
K. F. Remund, M. Best, and J. J. Egan
Infections Relevant to Lung Transplantation
Proceedings of the ATS, January 15, 2009; 6(1): 94 - 100.
[Abstract] [Full Text] [PDF]

Home page
 Arch. Dis. Child.Home page
A Simon, O Schildgen, and F Schuster
Viral infections in paediatric patients receiving conventional cancer chemotherapy
Arch. Dis. Child., October 1, 2008; 93(10): 880 - 889.
[Abstract] [Full Text] [PDF]

Home page
 Eur Respir JHome page
T. Jartti, W-M. Lee, T. Pappas, M. Evans, R. F. Lemanske Jr, and J. E. Gern
Serial viral infections in infants with recurrent respiratory illnesses
Eur. Respir. J., August 1, 2008; 32(2): 314 - 320.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
M. Wos, M. Sanak, J. Soja, H. Olechnowicz, W. W. Busse, and A. Szczeklik
The Presence of Rhinovirus in Lower Airways of Patients with Bronchial Asthma
Am. J. Respir. Crit. Care Med., May 15, 2008; 177(10): 1082 - 1089.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Microbiol. Rev.Home page
W. G. Nichols, A. J. Peck Campbell, and M. Boeckh
Respiratory Viruses Other than Influenza Virus: Impact and Therapeutic Advances
Clin. Microbiol. Rev., April 1, 2008; 21(2): 274 - 290.
[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Microbiol.Home page
X. Lu, B. Holloway, R. K. Dare, J. Kuypers, S. Yagi, J. V. Williams, C. B. Hall, and D. D. Erdman
Real-Time Reverse Transcription-PCR Assay for Comprehensive Detection of Human Rhinoviruses
J. Clin. Microbiol., February 1, 2008; 46(2): 533 - 539.
[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Microbiol.Home page
S. K. P. Lau, C. C. Y. Yip, H.-w. Tsoi, R. A. Lee, L.-y. So, Y.-l. Lau, K.-h. Chan, P. C. Y. Woo, and K.-y. Yuen
Clinical Features and Complete Genome Characterization of a Distinct Human Rhinovirus (HRV) Genetic Cluster, Probably Representing a Previously Undetected HRV Species, HRV-C, Associated with Acute Respiratory Illness in Children
J. Clin. Microbiol., November 1, 2007; 45(11): 3655 - 3664.
[Abstract] [Full Text] [PDF]

Home page
 Proc Am Thorac SocHome page
J. Yoo, H. Tcheurekdjian, S. V. Lynch, M. Cabana, and H. A. Boushey
Microbial Manipulation of Immune Function for Asthma Prevention: Inferences from Clinical Trials
Proceedings of the ATS, July 1, 2007; 4(3): 277 - 282.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
P. A. Corris and J. D. Christie
Update in Transplantation 2006
Am. J. Respir. Crit. Care Med., March 1, 2007; 175(5): 432 - 435.
[Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
M. B. Hershenson and S. L. Johnston
Rhinovirus Infections: More Than a Common Cold
Am. J. Respir. Crit. Care Med., December 15, 2006; 174(12): 1284 - 1285.
[Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH
Proc. Am. Thorac. Soc. Am. J. Respir. Cell Mol. Biol.
Copyright © 2006 American Thoracic Society 		  ATS Coding and Billing Quarterly