help button home button
AJRCCM
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH
Published ahead of print on October 19, 2006, doi:10.1164/rccm.200603-435PP

Am. J. Respir. Crit. Care Med., Volume 175, Number 2, January 2007, 108-119

A more recent version of this article appeared on January 15, 2007
This Article
Right arrow Full Text (PDF)
Right arrow All Versions of this Article:
200603-435PPv1
175/2/108    most recent
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Singh, A. M.
Right arrow Articles by Hartert, T. V
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Singh, A. M.
Right arrow Articles by Hartert, T. V

Submitted on March 28, 2006
Accepted on October 19, 2006

Bronchiolitis to Asthma:A Review and Call for Studies of Gene-Viral Interactions in Asthma Causation

Anne Marie Singh1*, Paul E Moore2, James E Gern3, Robert F Lemanske, Jr.4, and Tina V Hartert5

1 Department of Medicine, University of Wisconsin-Madison, Madison, WI, USA, 2 Department of Pediatrics, Vanderbilt University School of Medicine, Nashville, TN, USA, 3 Department of Pediatrics, University of Wisconsin-Madison, Madison, WI, USA, 4 Department of Medicine, University of Wisconsin-Madison, Madison, WI, USA; Department of Pediatrics, University of Wisconsin-Madison, Madison, WI, USA, 5 Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN, USA

* To whom correspondence should be addressed. E-mail: am.singh{at}hosp.wisc.edu.

Viral infections are important causes of asthma exacerbations in children, and lower respiratory tract infections (LRTI), caused by viruses such as respiratory syncytial virus (RSV) and rhinovirus (RV), are a leading cause of bronchiolitis in infants. Infants hospitalized with bronchiolitis are at significantly increased risk for both recurrent wheezing and childhood asthma. To date, studies addressing the incidence of asthma following bronchiolitis severe enough to warrant hospitalization have focused almost exclusively on RSV, but a number of recent studies suggest that other respiratory pathogens, including RV, may contribute as well. It is not known whether viral bronchiolitis directly contributes to asthma causation or simply identifies infants at risk for subsequent wheezing, as from an atopic predisposition or preexisting abnormal lung function. Alternatively, the properties of the infecting virus may be important. Thus, many possible determinants exist that may contribute to the severity of bronchiolitis and the subsequent development of asthma. One such determinant is the potential involvement of genetic susceptibility loci to asthma following viral bronchiolitis, a critical area that is just beginning to be evaluated. By clarifying the roles of both host (genetic) and virus (environment) specific factors that contribute to the frequency and severity of viral LRTI, it may be possible to determine if severe LRTIs cause asthma, or if asthma susceptibility predisposes patients to severe LRTI in response to viral infection. Characterizing these relationships offers the potential of identifying at-risk hosts in whom preventing or delaying infection could alter the phenotypic expression of asthma.
Key words: asthma, bronchiolitis, genetics, RSV, RV




This article has been cited by other articles:


Home page
 Am. J. Respir. Crit. Care Med.Home page
S. F. Thomsen, S. van der Sluis, L. G. Stensballe, D. Posthuma, A. Skytthe, K. O. Kyvik, D. L. Duffy, V. Backer, and H. Bisgaard
Exploring the Association between Severe Respiratory Syncytial Virus Infection and Asthma: A Registry-based Twin Study
Am. J. Respir. Crit. Care Med., June 15, 2009; 179(12): 1091 - 1097.
[Abstract] [Full Text] [PDF]

Home page
 CVIHome page
C. Scagnolari, F. Midulla, A. Pierangeli, C. Moretti, E. Bonci, R. Berardi, D. De Angelis, C. Selvaggi, P. Di Marco, E. Girardi, et al.
Gene Expression of Nucleic Acid-Sensing Pattern Recognition Receptors in Children Hospitalized for Respiratory Syncytial Virus-Associated Acute Bronchiolitis
Clin. Vaccine Immunol., June 1, 2009; 16(6): 816 - 823.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Cell Mol. Bio.Home page
H. Sugiura, T. Ichikawa, A. Koarai, S. Yanagisawa, Y. Minakata, K. Matsunaga, T. Hirano, K. Akamatsu, and M. Ichinose
Activation of Toll-Like Receptor 3 Augments Myofibroblast Differentiation
Am. J. Respir. Cell Mol. Biol., June 1, 2009; 40(6): 654 - 662.
[Abstract] [Full Text] [PDF]

Home page
 Proc Am Thorac SocHome page
E. W. Gelfand
Pediatric Asthma: A Different Disease
Proceedings of the ATS, May 1, 2009; 6(3): 278 - 282.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
L. C. Denlinger, L. Shi, A. Guadarrama, K. Schell, D. Green, A. Morrin, K. Hogan, R. L. Sorkness, W. W. Busse, and J. E. Gern
Attenuated P2X7 Pore Function as a Risk Factor for Virus-induced Loss of Asthma Control
Am. J. Respir. Crit. Care Med., February 15, 2009; 179(4): 265 - 270.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
R. T. Stein
Early-Life Viral Bronchiolitis in the Causal Pathway of Childhood Asthma: Is the Evidence There Yet?
Am. J. Respir. Crit. Care Med., December 1, 2008; 178(11): 1097 - 1098.
[Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
P. Wu, W. D. Dupont, M. R. Griffin, K. N. Carroll, E. F. Mitchel, T. Gebretsadik, and T. V. Hartert
Evidence of a Causal Role of Winter Virus Infection during Infancy in Early Childhood Asthma
Am. J. Respir. Crit. Care Med., December 1, 2008; 178(11): 1123 - 1129.
[Abstract] [Full Text] [PDF]

Home page
 Exp PhysiolHome page
Y. Tan, T. Yang, S. Liu, H. Liu, Y. Xiang, F. Qu, H. Li, and X. Qin
Infection with respiratory syncytial virus alters peptidergic innervation in the lower airways of guinea-pigs
Exp Physiol, December 1, 2008; 93(12): 1284 - 1291.
[Abstract] [Full Text] [PDF]

Home page
 ThoraxHome page
J Henderson, R Granell, J Heron, A Sherriff, A Simpson, A Woodcock, D P Strachan, S O Shaheen, and J A C Sterne
Associations of wheezing phenotypes in the first 6 years of life with atopy, lung function and airway responsiveness in mid-childhood
Thorax, November 1, 2008; 63(11): 974 - 980.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
D. J. Jackson, R. E. Gangnon, M. D. Evans, K. A. Roberg, E. L. Anderson, T. E. Pappas, M. C. Printz, W.-M. Lee, P. A. Shult, E. Reisdorf, et al.
Wheezing Rhinovirus Illnesses in Early Life Predict Asthma Development in High-Risk Children
Am. J. Respir. Crit. Care Med., October 1, 2008; 178(7): 667 - 672.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Microbiol. Rev.Home page
W. G. Nichols, A. J. Peck Campbell, and M. Boeckh
Respiratory Viruses Other than Influenza Virus: Impact and Therapeutic Advances
Clin. Microbiol. Rev., April 1, 2008; 21(2): 274 - 290.
[Abstract] [Full Text] [PDF]

Home page
 PediatricsHome page
S. F. Thomsen, L. G. Stensballe, A. Skytthe, K. O. Kyvik, V. Backer, and H. Bisgaard
Increased Concordance of Severe Respiratory Syncytial Virus Infection in Identical Twins
Pediatrics, March 1, 2008; 121(3): 493 - 496.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Cell Mol. Bio.Home page
R. S. Peebles Jr. and M. L. Moore
A Mechanistic Advance in Understanding RSV Pathogenesis, but Still a Long Way from Therapy
Am. J. Respir. Cell Mol. Biol., October 1, 2007; 37(4): 375 - 377.
[Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH
Proc. Am. Thorac. Soc. Am. J. Respir. Cell Mol. Biol.
Copyright © 2006 American Thoracic Society 		  CCM abstracts