help button home button
AJRCCM
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH
Published ahead of print on March 23, 2006, doi:10.1164/rccm.200510-1659PP

Am. J. Respir. Crit. Care Med., Volume 174, Number 1, July 2006, 6-14

A more recent version of this article appeared on July 1, 2006
This Article
Right arrow Full Text (PDF)
Right arrow All Versions of this Article:
200510-1659PPv1
174/1/6    most recent
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Barnes, P. J
Right arrow Articles by Saetta, M.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Barnes, P. J
Right arrow Articles by Saetta, M.

Submitted on October 24, 2005
Accepted on March 23, 2006

Pulmonary Biomarkers in COPD

Peter J Barnes1*, Badrul Chowdhury2, Sergei A Kharitonov1, Helgo Magnussen3, Clive P Page4, Dirkje Postma5, and Marina Saetta6

1 National Heart and Lung Institute, Imperial College, London, United Kingdom, 2 US Food and Drug Administration, Rockville, MD, USA, 3 Center for Pneumology and Thoracic Surgery, Grosshansdorf, Germany, 4 GKT School of Biomedical Sciences, Kings College, London, United Kingdom, 5 University Hospital Groningen, Groningen, The Netherlands, 6 Department of Cardiothoracic and Vascular Sciences, University of Padova, Padova, Italy

* To whom correspondence should be addressed. E-mail: p.j.barnes{at}imperial.ac.uk.

There has been increasing interest in using pulmonary biomarkers to understand and monitor the inflammation in the respiratory tract of patients with chronic obstructive pulmonary disease (COPD). In this Perspective we discuss the merits of the various approaches by reviewing the current literature on pulmonary biomarkers in COPD and underscore the need for more systematic studies in the future. Bronchial biopsies and bronchoalveolar lavage provide valuable information about inflammatory cells and mediators, but is invasive, so that repeated measurements have to be very limited in assessing any interventions. Induced sputum has provided considerable information about the inflammatory process, including mediators and proteinases in COPD, but selectively samples proximal airways and may not closely reflect distal inflammatory processes. Exhaled gases and breath condensate are non-invasive procedures so that repeated measurements are possible, but for some assays the variability is relatively high. There is relatively little information about how any of these biomarkers relate to other clinical outcomes, such as progression of the disease, severity of disease, clinical subtypes or response to therapy. More information is also needed about the variability in these measurements. In the future pulmonary biomarkers may be useful in predicting disease progression, indicating disease instability and in predicting response to current therapies and novel therapies, many of which are now in development.
Key words: bronchial biopsy, bronchoalveolar lavage, induced sputum, exhaled nitric oxide, exhaled breath condensate




This article has been cited by other articles:


Home page
 Eur Respir JHome page
M. Luisetti, S. Ma, P. Iadarola, P. J. Stone, S. Viglio, B. Casado, Y. Y. Lin, G. L. Snider, and G. M. Turino
Desmosine as a biomarker of elastin degradation in COPD: current status and future directions
Eur. Respir. J., November 1, 2008; 32(5): 1146 - 1157.
[Abstract] [Full Text] [PDF]

Home page
 ThoraxHome page
K Terada, S Muro, S Sato, T Ohara, A Haruna, S Marumo, D Kinose, E Ogawa, Y Hoshino, A Niimi, et al.
Impact of gastro-oesophageal reflux disease symptoms on COPD exacerbation
Thorax, November 1, 2008; 63(11): 951 - 955.
[Abstract] [Full Text] [PDF]

Home page
 ChestHome page
D. Stolz, M. Christ-Crain, N. G. Morgenthaler, D. Miedinger, J. Leuppi, C. Muller, R. Bingisser, J. Struck, B. Muller, and M. Tamm
Plasma Pro-Adrenomedullin But Not Plasma Pro-Endothelin Predicts Survival in Exacerbations of COPD
Chest, August 1, 2008; 134(2): 263 - 272.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
M. Dahl
Biomarkers for Chronic Obstructive Pulmonary Disease: Surfactant Protein D and C-Reactive Protein
Am. J. Respir. Crit. Care Med., June 1, 2008; 177(11): 1177 - 1178.
[Full Text] [PDF]

Home page
 ThoraxHome page
E Sapey, D Bayley, A Ahmad, P Newbold, N Snell, and R A Stockley
Inter-relationships between inflammatory markers in patients with stable COPD with bronchitis: intra-patient and inter-patient variability
Thorax, June 1, 2008; 63(6): 493 - 499.
[Abstract] [Full Text] [PDF]

Home page
 Eur Respir JHome page
M. Cazzola, W. MacNee, F. J. Martinez, K. F. Rabe, L. G. Franciosi, P. J. Barnes, V. Brusasco, P. S. Burge, P. M. A. Calverley, B. R. Celli, et al.
Outcomes for COPD pharmacological trials: from lung function to biomarkers
Eur. Respir. J., February 1, 2008; 31(2): 416 - 469.
[Abstract] [Full Text] [PDF]

Home page
 Eur Respir JHome page
B. Balbi, P. Pignatti, M. Corradi, P. Baiardi, L. Bianchi, G. Brunetti, A. Radaeli, G. Moscato, A. Mutti, A. Spanevello, et al.
Bronchoalveolar lavage, sputum and exhaled clinically relevant inflammatory markers: values in healthy adults
Eur. Respir. J., October 1, 2007; 30(4): 769 - 781.
[Abstract] [Full Text] [PDF]

Home page
 ChestHome page
D. A. Mahler, L. A. Waterman, J. Ward, C. McCusker, R. ZuWallack, and J. C. Baird
Validity and Responsiveness of the Self-Administered Computerized Versions of the Baseline and Transition Dyspnea Indexes
Chest, October 1, 2007; 132(4): 1283 - 1290.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
D. P. Schuster
The Opportunities and Challenges of Developing Imaging Biomarkers to Study Lung Function and Disease
Am. J. Respir. Crit. Care Med., August 1, 2007; 176(3): 224 - 230.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
K. F. Rabe, B. Beghe, F. Luppi, and L. M. Fabbri
Update in Chronic Obstructive Pulmonary Disease 2006
Am. J. Respir. Crit. Care Med., June 15, 2007; 175(12): 1222 - 1232.
[Full Text] [PDF]

Home page
 Eur Respir JHome page
B. R. Celli and P. J. Barnes
Exacerbations of chronic obstructive pulmonary disease
Eur. Respir. J., June 1, 2007; 29(6): 1224 - 1238.
[Abstract] [Full Text] [PDF]

Home page
 Eur Respir JHome page
H. Gunen, S. S. Hacievliyagil, O. Yetkin, G. Gulbas, L. C. Mutlu, and E. In
The role of nebulised budesonide in the treatment of exacerbations of COPD
Eur. Respir. J., April 1, 2007; 29(4): 660 - 667.
[Abstract] [Full Text] [PDF]

Home page
 ChestHome page
D. Stolz, M. Christ-Crain, N. G. Morgenthaler, J. Leuppi, D. Miedinger, R. Bingisser, C. Muller, J. Struck, B. Muller, and M. Tamm
Copeptin, C-Reactive Protein, and Procalcitonin as Prognostic Biomarkers in Acute Exacerbation of COPD
Chest, April 1, 2007; 131(4): 1058 - 1067.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
A. Van Muylem, C. Knoop, and M. Estenne
Early Detection of Chronic Pulmonary Allograft Dysfunction by Exhaled Biomarkers
Am. J. Respir. Crit. Care Med., April 1, 2007; 175(7): 731 - 736.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
M. Jaradat, C. Stapleton, S. L. Tilley, D. Dixon, C. J. Erikson, J. G. McCaskill, H. S. Kang, M. Angers, G. Liao, J. Collins, et al.
Modulatory Role for Retinoid-related Orphan Receptor {alpha} in Allergen-induced Lung Inflammation
Am. J. Respir. Crit. Care Med., December 15, 2006; 174(12): 1299 - 1309.
[Abstract] [Full Text] [PDF]

Home page
 ThoraxHome page
G M Turino
Emphysema in COPD: consequences and causes.
Thorax, December 1, 2006; 61(12): 1031 - 1036.
[Full Text] [PDF]

Home page
 ChestHome page
S. A. Kharitonov and P. J. Barnes
Exhaled biomarkers.
Chest, November 1, 2006; 130(5): 1541 - 1546.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
B. Muller and M. Tamm
Biomarkers in acute exacerbation of chronic obstructive pulmonary disease: among the blind, the one-eyed is king.
Am. J. Respir. Crit. Care Med., October 15, 2006; 174(8): 848 - 849.
[Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
D. Aronson, I. Roterman, M. Yigla, A. Kerner, O. Avizohar, R. Sella, P. Bartha, Y. Levy, and W. Markiewicz
Inverse Association between Pulmonary Function and C-Reactive Protein in Apparently Healthy Subjects
Am. J. Respir. Crit. Care Med., September 15, 2006; 174(6): 626 - 632.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH
Proc. Am. Thorac. Soc. Am. J. Respir. Cell Mol. Biol.
Copyright © 2006 American Thoracic Society 		  ATS State of the Art Course 2008