help button home button
AJRCCM
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH
Published ahead of print on March 9, 2006, doi:10.1164/rccm.200510-1584PP

Am. J. Respir. Crit. Care Med., Volume 173, Number 11, June 2006, 1186-1193

A more recent version of this article appeared on June 1, 2006
This Article
Right arrow Full Text (PDF)
Right arrow All Versions of this Article:
200510-1584PPv1
173/11/1186    most recent
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Gaston, B.
Right arrow Articles by Stamler, J. S
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Gaston, B.
Right arrow Articles by Stamler, J. S

Submitted on October 10, 2005
Accepted on March 6, 2006

S-Nitrosothiol Signaling in Respiratory Biology

Benjamin Gaston1*, David Singel2, Allan Doctor1, and Jonathan S Stamler3

1 Department of Pediatrics, University of Virginia Health System, Charlottesville, VA, USA, 2 Department of Chemistry, Montana State University, Boseman, MT, USA, 3 Department of Pulmonary Medicine and Cell Biology, Duke University, Durham, NC, USA

* To whom correspondence should be addressed. E-mail: bmg3g{at}virginia.edu.

Genetic and biochemical data demonstrate a pivotal role for S-nitrosothiols (SNOs) in mediating the actions of nitric oxide (NO) synthases. S-nitrosothiols (SNOs) serve to convey NO bioactivity and to regulate protein function. This understanding is of immediate interest to the pulmonary clinical and research communities. Here we review: 1) the biochemical and cellular evidence that SNOs in amino acids, peptides and proteins elicit NOS-dependent signaling in the respiratory system; 2) studies that link SNO signaling to pulmonary medicine. SNO-mediated signaling is involved in the regulation of minute ventilation, ventilation-perfusion matching, pulmonary arterial pressure, basal airway tone, and respiratory and peripheral muscle function. Derangements in SNO signaling are implicated in many disorders relevant to pulmonary and critical care medicine, including apnea, hypoxemia, pulmonary hypertension, asthma, cystic fibrosis (CF), pneumonia, and septic shock.
Key words: S-nitrosothiol, S-nitrosoglutathione, asthma, cystic fibrosis, pulmonary hypertension




This article has been cited by other articles:


Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
S. Mukhopadhyay, J. Lee, and P. B. Sehgal
Depletion of the ATPase NSF from Golgi membranes with hypo-S-nitrosylation of vasorelevant proteins in endothelial cells exposed to monocrotaline pyrrole
Am J Physiol Heart Circ Physiol, November 1, 2008; 295(5): H1943 - H1955.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
K. Ckless, A. Lampert, J. Reiss, D. Kasahara, M. E. Poynter, C. G. Irvin, L. K. A. Lundblad, R. Norton, A. van der Vliet, and Y. M. W. Janssen-Heininger
Inhibition of Arginase Activity Enhances Inflammation in Mice with Allergic Airway Disease, in Association with Increases in Protein S-Nitrosylation and Tyrosine Nitration
J. Immunol., September 15, 2008; 181(6): 4255 - 4264.
[Abstract] [Full Text] [PDF]

Home page
 Circ. Res.Home page
N. Marozkina, B. Gaston, and A. Doctor
Transnitrosation Signals Oxyhemoglobin Desaturation
Circ. Res., August 29, 2008; 103(5): 441 - 443.
[Full Text] [PDF]

Home page
 Am. J. Respir. Cell Mol. Bio.Home page
L. Chen, C. A. Bosworth, T. Pico, J. F. Collawn, K. Varga, Z. Gao, J. P. Clancy, J. A. Fortenberry, J. R. Lancaster Jr., and S. Matalon
DETANO and Nitrated Lipids Increase Chloride Secretion across Lung Airway Cells
Am. J. Respir. Cell Mol. Biol., August 1, 2008; 39(2): 150 - 162.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
O. M. Granillo, M. V. Brahmajothi, S. Li, A. R. Whorton, S. N. Mason, T. J. McMahon, and R. L. Auten
Pulmonary alveolar epithelial uptake of S-nitrosothiols is regulated by L-type amino acid transporter
Am J Physiol Lung Cell Mol Physiol, July 1, 2008; 295(1): L38 - L43.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
P. R. Castello, D. K. Woo, K. Ball, J. Wojcik, L. Liu, and R. O. Poyton
Reactive Oxygen Species Special Feature: Oxygen-regulated isoforms of cytochrome c oxidase have differential effects on its nitric oxide production and on hypoxic signaling
PNAS, June 17, 2008; 105(24): 8203 - 8208.
[Abstract] [Full Text] [PDF]

Home page
 J. Cell Sci.Home page
M.-Y. Kim, J.-H. Park, J.-S. Mo, E.-J. Ann, S.-O. Han, S.-H. Baek, K.-J. Kim, S.-Y. Im, J.-W. Park, E.-J. Choi, et al.
Downregulation by lipopolysaccharide of Notch signaling, via nitric oxide
J. Cell Sci., May 1, 2008; 121(9): 1466 - 1476.
[Abstract] [Full Text] [PDF]

Home page
 CirculationHome page
B. Yu, M. J. Raher, G. P. Volpato, K. D. Bloch, F. Ichinose, and W. M. Zapol
Inhaled Nitric Oxide Enables Artificial Blood Transfusion Without Hypertension
Circulation, April 15, 2008; 117(15): 1982 - 1990.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
D. Singh, D. Richards, R. G. Knowles, S. Schwartz, A. Woodcock, S. Langley, and B. J. O'Connor
Selective Inducible Nitric Oxide Synthase Inhibition Has No Effect on Allergen Challenge in Asthma
Am. J. Respir. Crit. Care Med., November 15, 2007; 176(10): 988 - 993.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Cell Mol. Bio.Home page
D. J. Carver, B. Gaston, K. deRonde, and L. A. Palmer
Akt-Mediated Activation of HIF-1 in Pulmonary Vascular Endothelial Cells by S-Nitrosoglutathione
Am. J. Respir. Cell Mol. Biol., September 1, 2007; 37(3): 255 - 263.
[Abstract] [Full Text] [PDF]

Home page
 Arterioscler. Thromb. Vasc. Bio.Home page
M. P. Coggins and K. D. Bloch
Nitric Oxide in the Pulmonary Vasculature
Arterioscler. Thromb. Vasc. Biol., September 1, 2007; 27(9): 1877 - 1885.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
R. L. Auten, S. N. Mason, M. H. Whorton, W. R. Lampe, W. M. Foster, R. N. Goldberg, B. Li, J. S. Stamler, and K. M. Auten
Inhaled Ethyl Nitrite Prevents Hyperoxia-impaired Postnatal Alveolar Development in Newborn Rats
Am. J. Respir. Crit. Care Med., August 1, 2007; 176(3): 291 - 299.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
W. C. Moore and S. P. Peters
Update in Asthma 2006
Am. J. Respir. Crit. Care Med., April 1, 2007; 175(7): 649 - 654.
[Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
A. S. Jackson, A. Sandrini, C. Campbell, S. Chow, P. S. Thomas, and D. H. Yates
Comparison of Biomarkers in Exhaled Breath Condensate and Bronchoalveolar Lavage
Am. J. Respir. Crit. Care Med., February 1, 2007; 175(3): 222 - 227.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Pharmacol.Home page
K. Zaman, S. Carraro, J. Doherty, E. M. Henderson, E. Lendermon, L. Liu, G. Verghese, M. Zigler, M. Ross, E. Park, et al.
S-Nitrosylating Agents: A Novel Class of Compounds That Increase Cystic Fibrosis Transmembrane Conductance Regulator Expression and Maturation in Epithelial Cells
Mol. Pharmacol., October 1, 2006; 70(4): 1435 - 1442.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Pharmacol.Home page
P. L. Zeitlin
Is It Go or NO Go for S-Nitrosylation Modification-Based Therapies of Cystic Fibrosis Transmembrane Regulator Trafficking?
Mol. Pharmacol., October 1, 2006; 70(4): 1155 - 1158.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
H. Grasemann, F. Kurtz, and F. Ratjen
Inhaled L-Arginine Improves Exhaled Nitric Oxide and Pulmonary Function in Patients with Cystic Fibrosis
Am. J. Respir. Crit. Care Med., July 15, 2006; 174(2): 208 - 212.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH
Proc. Am. Thorac. Soc. Am. J. Respir. Cell Mol. Biol.
Copyright © 2006 American Thoracic Society 		  ATS State of the Art Course 2008