Published ahead of print on February 2, 2006, doi:10.1164/rccm.200509-1489OC
Am. J. Respir. Crit. Care Med., Volume 173, Number 8, April 2006, 871-876
A more recent version of this article appeared on April 15, 2006
Submitted on September 23, 2005
Accepted on February 1, 2006
Respiratory Syncytial Virus, Airway Inflammation and FEV1 Decline in Patients with COPD
Tom M.A. Wilkinson1, Gavin C Donaldson1, Sebastian L Johnston2, Peter J.M. Openshaw2, and Jadwiga A Wedzicha1*
1 Academic Unit of Respiratory Medicine, University College of London, London, England, United Kingdom,
2 Department of Respiratory Medicine, National Heart and Lung Institute, Imperial College, London, England, United Kingdom
* To whom correspondence should be addressed. E-mail: j.a.wedzicha{at}medsch.ucl.ac.uk.
Background: Respiratory Syncytial Virus (RSV) is increasingly recognised as an important pathogen in adults with cardiopulmonary disease. It has been associated
with acute exacerbations of COPD; however it has also been detected in the lower airway in the stable state, but the consequences of RSV in stable disease have not
previously been determined. We therefore studied the consequences of RSV persistence in adults with COPD and its effect on airway inflammation and lung function decline.
Methods: 241 sputum samples from 74 COPD patients, FEV1 % predicted; 39.2 (29.6 - 57.8) %, were collected quarterly in the stable state over 2 years. RSV was detected by PCR, quantitative microbiology performed and inflammatory cytokines quantified by ELISA.
Results: RSV RNA was detected in 32.8% of sputum samples. Patients in whom RSV was more frequently detected, (>50% of samples RSV PCR positive, n=18), had higher airway inflammation and faster FEV1 decline over the study; (101.4 ml/year (95% CI 145.8 to 57.1) compared to those with less frequent detection of RSV (n=56, 51.2 ml/year (70.8 to 31.7); p = 0.01). The observed relationship between RSV detection and accelerated lung function decline was independent of smoking status, exacerbation frequency and lower airway bacterial load.
Conclusions: Persistent RSV detection in COPD patients is associated with airway inflammation and accelerated decline in FEV1. Chronic RSV infection may be a novel therapeutic target to alter the natural history of COPD.
Key words: COPD, RSV, FEV1 Decline
This article has been cited by other articles:
|
|
|
|
 
T. Seemungal, A. Sykes, and and the ICEAD Contributors
Recent advances in exacerbations of COPD
Thorax,
October 1, 2008;
63(10):
850 - 852.
[Full Text]
[PDF]
|
|
|
|
|
|
|
N. Hizawa, H. Makita, Y. Nasuhara, M. Hasegawa, K. Nagai, Y. Ito, T. Betsuyaku, S. Konno, M. Nishimura, and the Hokkaido COPD Cohort Study Group
Functional single nucleotide polymorphisms of the CCL5 gene and nonemphysematous phenotype in COPD patients
Eur. Respir. J.,
August 1, 2008;
32(2):
372 - 378.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
N. MacIntyre and Y. C. Huang
Acute Exacerbations and Respiratory Failure in Chronic Obstructive Pulmonary Disease
Proceedings of the ATS,
May 1, 2008;
5(4):
530 - 535.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
W. G. Nichols, A. J. Peck Campbell, and M. Boeckh
Respiratory Viruses Other than Influenza Virus: Impact and Therapeutic Advances
Clin. Microbiol. Rev.,
April 1, 2008;
21(2):
274 - 290.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
P. L. Collins and B. S. Graham
Viral and Host Factors in Human Respiratory Syncytial Virus Pathogenesis
J. Virol.,
March 1, 2008;
82(5):
2040 - 2055.
[Full Text]
[PDF]
|
|
|
|
|
|
|
F. J. Martinez
Pathogen-directed Therapy in Acute Exacerbations of Chronic Obstructive Pulmonary Disease
Proceedings of the ATS,
December 1, 2007;
4(8):
647 - 658.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. A. Martinez-Garcia, J.-J. Soler-Cataluna, M. Perpina-Tordera, P. Roman-Sanchez, and J. Soriano
Factors Associated With Lung Function Decline in Adult Patients With Stable Non-Cystic Fibrosis Bronchiectasis
Chest,
November 1, 2007;
132(5):
1565 - 1572.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
N. Minematsu and S. D. Shapiro
To Live and Die in the LA (Lung Airway): Mode of Neutrophil Death and Progression of Chronic Obstructive Pulmonary Disease
Am. J. Respir. Cell Mol. Biol.,
August 1, 2007;
37(2):
129 - 130.
[Full Text]
[PDF]
|
|
|
|
|
|
|
K. F. Rabe, B. Beghe, F. Luppi, and L. M. Fabbri
Update in Chronic Obstructive Pulmonary Disease 2006
Am. J. Respir. Crit. Care Med.,
June 15, 2007;
175(12):
1222 - 1232.
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. R. Edwards, J. Haas, R. A. Panettieri Jr., M. Johnson, and S. L. Johnston
Corticosteroids and beta2 Agonists Differentially Regulate Rhinovirus-induced Interleukin-6 via Distinct Cis-acting Elements
J. Biol. Chem.,
May 25, 2007;
282(21):
15366 - 15375.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
N. Takabatake, Y. Shibata, S. Abe, T. Wada, J.-i. Machiya, A. Igarashi, Y. Tokairin, G. Ji, H. Sato, M. Sata, et al.
A Single Nucleotide Polymorphism in the CCL1 Gene Predicts Acute Exacerbations in Chronic Obstructive Pulmonary Disease
Am. J. Respir. Crit. Care Med.,
October 15, 2006;
174(8):
875 - 885.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
D. Aronson, I. Roterman, M. Yigla, A. Kerner, O. Avizohar, R. Sella, P. Bartha, Y. Levy, and W. Markiewicz
Inverse Association between Pulmonary Function and C-Reactive Protein in Apparently Healthy Subjects
Am. J. Respir. Crit. Care Med.,
September 15, 2006;
174(6):
626 - 632.
[Abstract]
[Full Text]
[PDF]
|
|
|
Copyright © 2006 American Thoracic Society
|
|
|
