help button home button
AJRCCM
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH
Published ahead of print on January 26, 2006, doi:10.1164/rccm.200508-1344OC

Am. J. Respir. Crit. Care Med., Volume 173, Number 9, May 2006, 985-990

A more recent version of this article appeared on May 1, 2006
This Article
Right arrow Full Text (PDF)
Right arrow All Versions of this Article:
200508-1344OCv1
173/9/985    most recent
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Mannino, D. M
Right arrow Articles by Davis, K. J
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Mannino, D. M
Right arrow Articles by Davis, K. J

Submitted on August 30, 2005
Accepted on January 26, 2006

Lung Function Decline and Outcomes in an Adult Population

David M Mannino1*, Matthew M Reichert1, and Kourtney J Davis2

1 Division of Pulmonary and Critical Care Medicine, University of Kentucky Medical Center, Lexington, KY, USA, 2 Research and Development, GlaxoSmithKline, Research Triangle Park, NC, USA

* To whom correspondence should be addressed. E-mail: dmannino{at}uky.edu.

Rationale: Chronic obstructive pulmonary disease (COPD) is an important cause of morbidity and mortality. Objectives: To determine risk factors for and outcomes of rapid lung function decline in a cohort of U.S. adults. Methods: We analyzed data from 15,536 adults aged 44-66 years in the Atherosclerosis Risk in Communities (ARIC) study. We used Cox proportional hazard models to determine the risk of rapid lung function decline at three years on mortality and COPD hospitalizations over the subsequent eight years. Measurements and Main Results: Of those in the baseline cohort, 13,756 (88.5%) had spirometry at the year 3 visit. The strongest risk factors for not having a follow-up spirometry were being GOLD stage 3 or 4 at baseline (adjusted odds ratio [OR] 2.8, 95% confidence interval [CI] 2.1, 3.8), being of black race (adjusted OR 2.4, 95% CI 2.1, 2.7), and being a current smoker (adjusted OR 1.8, 95% CI 1.5, 2.0). Participants with GOLD stage 3 or 4 were also more likely to be in the most rapidly declining lung function quartile (adjusted OR 3.7, 95% CI 2.7, 5.0). Overall, participants with the most rapidly declining lung function had a modestly increased risk of death (adjusted hazard ratio [HR] 1.4, 95% CI 1.2, 1.7) and time to a COPD-related hospitalization (adjusted HR 1.4, 95% CI 1.2, 1.8). Conclusion: Rapid lung function decline was independently associated with a modest increased risk of COPD hospitalizations and deaths.
Key words: COPD, lung function, mortality




This article has been cited by other articles:


Home page
 Postgrad. Med. J.Home page
R P Young, R Hopkins, and T E Eaton
Potential benefits of statins on morbidity and mortality in chronic obstructive pulmonary disease: a review of the evidence
Postgrad. Med. J., August 1, 2009; 85(1006): 414 - 421.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
R. Kohansal, P. Martinez-Camblor, A. Agusti, A. S. Buist, D. M. Mannino, and J. B. Soriano
The Natural History of Chronic Airflow Obstruction Revisited: An Analysis of the Framingham Offspring Cohort
Am. J. Respir. Crit. Care Med., July 1, 2009; 180(1): 3 - 10.
[Abstract] [Full Text] [PDF]

Home page
 Am J EpidemiolHome page
J. A. Nettleton, J. L. Follis, and M. B. Schabath
Coffee Intake, Smoking, and Pulmonary Function in the Atherosclerosis Risk in Communities Study
Am. J. Epidemiol., June 15, 2009; 169(12): 1445 - 1453.
[Abstract] [Full Text] [PDF]

Home page
 Eur Respir JHome page
N. S. Godtfredsen, T. H. Lam, T. T. Hansel, M. E. Leon, N. Gray, C. Dresler, D. M. Burns, E. Prescott, and J. Vestbo
COPD-related morbidity and mortality after smoking cessation: status of the evidence
Eur. Respir. J., October 1, 2008; 32(4): 844 - 853.
[Abstract] [Full Text] [PDF]

Home page
 ThoraxHome page
P-O Bridevaux, M W Gerbase, N M Probst-Hensch, C Schindler, J-M Gaspoz, and T Rochat
Long-term decline in lung function, utilisation of care and quality of life in modified GOLD stage 1 COPD
Thorax, September 1, 2008; 63(9): 768 - 774.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
K. F. Rabe, B. Beghe, F. Luppi, and L. M. Fabbri
Update in Chronic Obstructive Pulmonary Disease 2006
Am. J. Respir. Crit. Care Med., June 15, 2007; 175(12): 1222 - 1232.
[Full Text] [PDF]

Home page
 Eur. J. Cardiothorac. Surg.Home page
F. Leo, P. Scanagatta, P. Baglio, D. Radice, G. Veronesi, P. Solli, F. Petrella, and L. Spaggiari
The risk of pneumonectomy over the age of 70.: A case-control study
Eur. J. Cardiothorac. Surg., May 1, 2007; 31(5): 779 - 782.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
P. H. Quanjer, J. P. Schouten, M. R. Miller, and G. Ruppel
Avoiding Bias in the Annualized Rate of Change of FEV1
Am. J. Respir. Crit. Care Med., February 1, 2007; 175(3): 291 - 292.
[Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
D. M. Mannino, M. M. Reichert, and K. J. Davis

Am. J. Respir. Crit. Care Med., February 1, 2007; 175(3): 292 - 292.
[Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
R. de Marco, S. Accordini, I. Cerveri, A. Corsico, J. M. Anto, N. Kunzli, C. Janson, J. Sunyer, D. Jarvis, S. Chinn, et al.
Incidence of Chronic Obstructive Pulmonary Disease in a Cohort of Young Adults According to the Presence of Chronic Cough and Phlegm
Am. J. Respir. Crit. Care Med., January 1, 2007; 175(1): 32 - 39.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH
Proc. Am. Thorac. Soc. Am. J. Respir. Cell Mol. Biol.
Copyright © 2006 American Thoracic Society 		  ATS Quiz on Sleep Study Tracings