help button home button
AJRCCM
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH
Published ahead of print on February 2, 2006, doi:10.1164/rccm.200507-1140OC

Am. J. Respir. Crit. Care Med., Volume 173, Number 8, April 2006, 890-896

A more recent version of this article appeared on April 15, 2006
This Article
Right arrow Full Text (PDF)
Right arrow All Versions of this Article:
200507-1140OCv1
173/8/890    most recent
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Vrijlandt, E. J.L.E.
Right arrow Articles by Duiverman, E. J
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Vrijlandt, E. J.L.E.
Right arrow Articles by Duiverman, E. J

Submitted on July 25, 2005
Accepted on January 27, 2006

Lung Function and Exercise Capacity in Young Adults Born Prematurely

Elianne J.L.E. Vrijlandt1*, Jorrit Gerritsen1, H. Marike Boezen2, Rene G Grevink3, and Eric J Duiverman1

1 Department of Pediatric Pulmonology, Beatrix Children's Hospital Groningen, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands, 2 Department of Epidemiology and Bioinformatics, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands, 3 Department of Pulmonology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands

* To whom correspondence should be addressed. E-mail: e.j.l.e.vrijlandt{at}bkk.umcg.nl.

Rationale Limited information is available about the long-term outcome of lung function and exercise capacity in young adults born prematurely. Objective To determine long term effects of prematurity on lung function (volumes, diffusing capacity) and exercise capacity in ex-preterms compared to healthy peers. Methods In a prospective cohort study, children born with a gestational age of < 32 weeks and/or a birth weight < 1500g were followed up for 19 years. Participants (n=42, mean gestational age 30 weeks and mean birth weight 1246g) and healthy term controls (n=48) were recruited for lung function and exercise tests. Measurements Spirometry, bodybox (TLCbox), diffusing capacity (TLCO), bicycle ergometer test. Main Results Preterm birth was associated with lower FEV1 (preterms 95% pred vs controls 110% pred, p<0.001), TLCOsb (88% pred vs 96% pred, p=0.003) and exercise capacity (load 185 Watt vs 216 Watt, p<0.001, anaerobic threshold (mean 1546 ml/min vs 1839 ml/min, p<0.001) compared to controls at follow up. No differences between the groups were found in TLCbox, peak oxygen consumption (VO2) and breathing reserve. No significant differences in lung function and exercise parameters were found between preterms with and without Bronchopulmonary Dysplasia. Conclusions Long term effects of prematurity were airway obstruction and a lower CO diffusing capacity compared to controls, although mean lung function parameters were within the normal range. Ex-preterms had a lower exercise level, which could not be explained by impaired lung function or smoking habits, but might be due to impaired physical fitness.
Key words: lung function, exercise capacity, ex-preterms




This article has been cited by other articles:


Home page
 J. Appl. Physiol.Home page
R. De Matteo, K. Snibson, B. Thompson, E. Koumoundouros, and R. Harding
Lung function in developing lambs: is it affected by preterm birth?
J Appl Physiol, October 1, 2009; 107(4): 1083 - 1088.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
I. Narang, A. Bush, and M. Rosenthal
Gas Transfer and Pulmonary Blood Flow at Rest and during Exercise in Adults 21 Years after Preterm Birth
Am. J. Respir. Crit. Care Med., August 15, 2009; 180(4): 339 - 345.
[Abstract] [Full Text] [PDF]

Home page
 Eur Respir JHome page
A. Barbato, F. Bertuola, C. Kuehni, M. Korppi, S. Kotecha, M. W. Pijnenburg, F. Ratjen, P. Seddon, and A. Bush
Paediatrics in Berlin
Eur. Respir. J., August 1, 2009; 34(2): 436 - 443.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
E. C. Walter, W. J. Ehlenbach, D. L. Hotchkin, J. W. Chien, and T. D. Koepsell
Low Birth Weight and Respiratory Disease in Adulthood: A Population-based Case-Control Study
Am. J. Respir. Crit. Care Med., July 15, 2009; 180(2): 176 - 180.
[Abstract] [Full Text] [PDF]

Home page
 PediatricsHome page
A. Bhandari and V. Bhandari
Pitfalls, Problems, and Progress in Bronchopulmonary Dysplasia
Pediatrics, June 1, 2009; 123(6): 1562 - 1573.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
A. Bush
Update in Pediatric Lung Disease 2008
Am. J. Respir. Crit. Care Med., April 15, 2009; 179(8): 637 - 649.
[Full Text] [PDF]

Home page
 ThoraxHome page
R J Hancox, R Poulton, J M Greene, C R McLachlan, M S Pearce, and M R Sears
Associations between birth weight, early childhood weight gain and adult lung function
Thorax, March 1, 2009; 64(3): 228 - 232.
[Abstract] [Full Text] [PDF]

Home page
 Eur Respir JHome page
P. M. Wong, A. N. Lees, J. Louw, F. Y. Lee, N. French, K. Gain, C. P. Murray, A. Wilson, and D. C. Chambers
Emphysema in young adult survivors of moderate-to-severe bronchopulmonary dysplasia
Eur. Respir. J., August 1, 2008; 32(2): 321 - 328.
[Abstract] [Full Text] [PDF]

Home page
 PediatricsHome page
L. J. Smith, P. P. van Asperen, K. O. McKay, H. Selvadurai, and D. A. Fitzgerald
Reduced Exercise Capacity in Children Born Very Preterm
Pediatrics, August 1, 2008; 122(2): e287 - e293.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
I. Narang, M. Rosenthal, D. Cremonesini, M. Silverman, and A. Bush
Longitudinal Evaluation of Airway Function 21 Years after Preterm Birth
Am. J. Respir. Crit. Care Med., July 1, 2008; 178(1): 74 - 80.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
A. Bush
Update in Pediatric Lung Disease 2007
Am. J. Respir. Crit. Care Med., April 1, 2008; 177(7): 686 - 695.
[Full Text] [PDF]

Home page
 NEJMHome page
E. Baraldi and M. Filippone
Chronic Lung Disease after Premature Birth
N. Engl. J. Med., November 8, 2007; 357(19): 1946 - 1955.
[Full Text] [PDF]

Home page
 Proc Am Thorac SocHome page
G. Tino
Clinical Year in Review I: Lung Cancer, Interventional Pulmonology, Pediatric Pulmonary Disease, and Pulmonary Vascular Disease
Proceedings of the ATS, September 15, 2007; 4(6): 478 - 481.
[Full Text] [PDF]

Home page
 PediatricsHome page
E. T. M. Hille, N. Weisglas-Kuperus, J. B. van Goudoever, G. W. Jacobusse, M. H. Ens-Dokkum, L. de Groot, J. M. Wit, W. B. Geven, J. H. Kok, M. J. K. de Kleine, et al.
Functional Outcomes and Participation in Young Adulthood for Very Preterm and Very Low Birth Weight Infants: The Dutch Project on Preterm and Small for Gestational Age Infants at 19 Years of Age
Pediatrics, September 1, 2007; 120(3): e587 - e595.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
D. Caudri, A. Wijga, U. Gehring, H. A. Smit, B. Brunekreef, M. Kerkhof, M. Hoekstra, J. Gerritsen, and J. C. de Jongste
Respiratory Symptoms in the First 7 Years of Life and Birth Weight at Term: The PIAMA Birth Cohort
Am. J. Respir. Crit. Care Med., May 15, 2007; 175(10): 1078 - 1085.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
A. Bush
Update in Pediatric Lung Disease 2006
Am. J. Respir. Crit. Care Med., March 15, 2007; 175(6): 532 - 540.
[Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
E. J. L. E. Vrijlandt, J. Gerritsen, H. M. Boezen, R. G. Grevink, and E. J. Duiverman
Appropriate Interpretation of Lung Function and Exercise Capacity in a Longitudinal Follow-up of Preterm Children
Am. J. Respir. Crit. Care Med., January 1, 2007; 175(1): 97 - 97.
[Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
J. Kirkby, S. Stanojevic, and J. Stocks
Appropriate Interpretation of Lung Function and Exercise Capacity in a Longitudinal Follow-up of Preterm Children
Am. J. Respir. Crit. Care Med., January 1, 2007; 175(1): 96a - 97.
[Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH
Proc. Am. Thorac. Soc. Am. J. Respir. Cell Mol. Biol.
Copyright © 2006 American Thoracic Society 		  ATS 2008 State of the Art Course