help button home button
AJRCCM
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH
Published ahead of print on August 26, 2005, doi:10.1164/rccm.200506-953OC

Am. J. Respir. Crit. Care Med., Volume 172, Number 11, December 2005, 1378-1382

A more recent version of this article appeared on December 1, 2005
This Article
Right arrow Full Text (PDF)
Right arrow All Versions of this Article:
200506-953OCv1
172/11/1378    most recent
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Ito, I.
Right arrow Articles by Mishima, M.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Ito, I.
Right arrow Articles by Mishima, M.

Submitted on June 20, 2005
Accepted on August 26, 2005

Matrix Metalloproteinase-9 Promoter Polymorphism Associated with Upper Lung Dominant Emphysema

Isao Ito1, Sonoko Nagai1*, Tomohiro Handa1, Shigeo Muro1, Toyohiro Hirai1, Mitsuhiro Tsukino1, and Michiaki Mishima1

1 Department of Respiratory Medicine, Kyoto University, Graduate School of Medicine, Kyoto, Japan

* To whom correspondence should be addressed. E-mail: nagai{at}kuhp.kyoto-u.ac.jp.

Rationale: Matrix metalloproteinase 9 (MMP-9) has proteolytic activity against connective tissue proteins and appears to play an important role in the development of chronic obstructive pulmonary disease (COPD). The functional polymorphism of MMP-9 (C-1562T) is considered as one of the candidate genes in the susceptibility to COPD. Objectives: To determine if MMP-9 (C-1562T) is related to the development of COPD in the Japanese population and whether it is associated with development of pulmonary emphysema; assessed by high-resolution computed tomographic (HRCT) parameters. Methods: 84 COPD patients and 85 healthy smoker controls were genotyped for MMP-9 (C-1562T) by the restriction fragment length polymorphism method. We further investigated the relationship between the genotype using automatically analyzed HRCT parameters such as low attenuation area % (LAA%) and average CT value density (Hounsfield unit) (mean-CTv) in upper, middle and lower lung fields in all COPD patients. Measurements and Main Results: There was no difference in polymorphism of MMP-9 (C-1562T) between COPD patients and smoker controls. In the HRCT study, COPD patients with a T-allele (C/T or T/T) showed larger LAA% (95%CI of difference: 0.5 to 18.7, p=0.04), and smaller mean-CTv (-34.3 to -1.0, p=0.04) in the upper lung compared to patients without T-alleles (C/C). However, pulmonary function tests showed no difference between the two patient groups. Patients with a T-allele showed a decrease in LAA% and an increase in mean-CTv from upper to lower lung fields (p=0.006 and p=0.002). Conclusions: Polymorphism of MMP-9 (C-1562T) was associated with upper lung dominant emphysema in patients with COPD.
Key words: High-resolution computed tomography, Low attenuation area %, Mean-CT value, Chronic obstructive pulmonary disease




This article has been cited by other articles:


Home page
 Am. J. Respir. Crit. Care Med.Home page
J. Smolonska, C. Wijmenga, D. S. Postma, and H. M. Boezen
Meta-analyses on Suspected Chronic Obstructive Pulmonary Disease Genes: A Summary of 20 Years' Research
Am. J. Respir. Crit. Care Med., October 1, 2009; 180(7): 618 - 631.
[Abstract] [Full Text] [PDF]

Home page
 ChestHome page
E. S. Wan and E. K. Silverman
Genetics of COPD and Emphysema
Chest, September 1, 2009; 136(3): 859 - 866.
[Abstract] [Full Text] [PDF]

Home page
 FASEB J.Home page
Y. Nakamaru, C. Vuppusetty, H. Wada, J. C. Milne, M. Ito, C. Rossios, M. Elliot, J. Hogg, S. Kharitonov, H. Goto, et al.
A protein deacetylase SIRT1 is a negative regulator of metalloproteinase-9
FASEB J, September 1, 2009; 23(9): 2810 - 2819.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
V. V. Gupte, S. K. Ramasamy, R. Reddy, J. Lee, P. H. Weinreb, S. M. Violette, A. Guenther, D. Warburton, B. Driscoll, P. Minoo, et al.
Overexpression of Fibroblast Growth Factor-10 during Both Inflammatory and Fibrotic Phases Attenuates Bleomycin-induced Pulmonary Fibrosis in Mice
Am. J. Respir. Crit. Care Med., September 1, 2009; 180(5): 424 - 436.
[Abstract] [Full Text] [PDF]

Home page
 Chronic Respiratory DiseaseHome page
C. Bolton, M. Stone, P. Edwards, J. Duckers, W. Evans, and D. Shale
Circulating matrix metalloproteinase-9 and osteoporosis in patients with chronic obstructive pulmonary disease
Chronic Respiratory Disease, May 1, 2009; 6(2): 81 - 87.
[Abstract] [PDF]

Home page
 ThoraxHome page
S J Marciniak and D A Lomas
What can naturally occurring mutations tell us about the pathogenesis of COPD?
Thorax, April 1, 2009; 64(4): 359 - 364.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
A. Chetty, G.-J. Cao, M. Severgnini, A. Simon, R. Warburton, and H. C. Nielsen
Role of matrix metalloprotease-9 in hyperoxic injury in developing lung
Am J Physiol Lung Cell Mol Physiol, October 1, 2008; 295(4): L584 - L592.
[Abstract] [Full Text] [PDF]

Home page
 Ther Adv Respir DisHome page
A. M. Wood and R. A. Stockley
Editorial: Unifying the genetics, co-morbidities and management of COPD
Therapeutic Advances in Respiratory Disease, June 1, 2008; 2(3): 113 - 117.
[PDF]

Home page
 ChestHome page
Z. Ammous, N. R. Hackett, M. W. Butler, T. Raman, I. Dolgalev, T. P. O'Connor, B.-G. Harvey, and R. G. Crystal
Variability in Small Airway Epithelial Gene Expression Among Normal Smokers
Chest, June 1, 2008; 133(6): 1344 - 1353.
[Abstract] [Full Text] [PDF]

Home page
 Proc Am Thorac SocHome page
C. P. Hersh, D. L. DeMeo, and E. K. Silverman
National Emphysema Treatment Trial State of the Art: Genetics of Emphysema
Proceedings of the ATS, May 1, 2008; 5(4): 486 - 493.
[Abstract] [Full Text] [PDF]

Home page
 Biol LettHome page
G. Luikart, K. Pilgrim, J. Visty, V. O Ezenwa, and M. K Schwartz
Candidate gene microsatellite variation is associated with parasitism in wild bighorn sheep
Biol Lett, April 23, 2008; 4(2): 228 - 231.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
D. A. McAllister, J. D. Maclay, N. L. Mills, G. Mair, J. Miller, D. Anderson, D. E. Newby, J. T. Murchison, and W. MacNee
Arterial Stiffness Is Independently Associated with Emphysema Severity in Patients with Chronic Obstructive Pulmonary Disease
Am. J. Respir. Crit. Care Med., December 15, 2007; 176(12): 1208 - 1214.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
L. Plantier, S. Marchand-Adam, V. G. Antico, L. Boyer, C. De Coster, J. Marchal, R. Bachoual, A. Mailleux, J. Boczkowski, and B. Crestani
Keratinocyte growth factor protects against elastase-induced pulmonary emphysema in mice
Am J Physiol Lung Cell Mol Physiol, November 1, 2007; 293(5): L1230 - L1239.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Cell Mol. Bio.Home page
P. T. Elkington, J. A. Green, J. E. Emerson, L. D. Lopez-Pascua, J. J. Boyle, C. M. O'Kane, and J. S. Friedland
Synergistic Up-Regulation of Epithelial Cell Matrix Metalloproteinase-9 Secretion in Tuberculosis
Am. J. Respir. Cell Mol. Biol., October 1, 2007; 37(4): 431 - 437.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
L. M. Fabbri, P. Boschetto, and C. E. Mapp
COPD Guidelines: The Important Thing Is Not to Stop Questioning
Am. J. Respir. Crit. Care Med., September 15, 2007; 176(6): 527 - 528.
[Full Text] [PDF]

Home page
 ChestHome page
J. Holme and R. A. Stockley
Radiologic and Clinical Features of COPD Patients With Discordant Pulmonary Physiology: Lessons From {alpha}1-Antitrypsin Deficiency
Chest, September 1, 2007; 132(3): 909 - 915.
[Abstract] [Full Text] [PDF]

Home page
 ThoraxHome page
A. Churg, R. Wang, X. Wang, P.-O. Onnervik, K. Thim, and J. L Wright
Effect of an MMP-9/MMP-12 inhibitor on smoke-induced emphysema and airway remodelling in guinea pigs
Thorax, August 1, 2007; 62(8): 706 - 713.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
D. L. DeMeo, C. P. Hersh, E. A. Hoffman, A. A. Litonjua, R. Lazarus, D. Sparrow, J. O. Benditt, G. Criner, B. Make, F. J. Martinez, et al.
Genetic Determinants of Emphysema Distribution in the National Emphysema Treatment Trial
Am. J. Respir. Crit. Care Med., July 1, 2007; 176(1): 42 - 48.
[Abstract] [Full Text] [PDF]

Home page
 Postgrad. Med. J.Home page
F. Sampsonas, A. Kaparianos, D. Lykouras, K. Karkoulias, and K. Spiropoulos
DNA sequence variations of metalloproteinases: their role in asthma and COPD
Postgrad. Med. J., April 1, 2007; 83(978): 244 - 250.
[Abstract] [Full Text] [PDF]

Home page
 Physiol. Rev.Home page
K. J. Greenlee, Z. Werb, and F. Kheradmand
Matrix Metalloproteinases in Lung: Multiple, Multifarious, and Multifaceted
Physiol Rev, January 1, 2007; 87(1): 69 - 98.
[Abstract] [Full Text] [PDF]

Home page
 PhysiologyHome page
D. G. Morris and D. Sheppard
Pulmonary Emphysema: When More is Less.
Physiology, December 1, 2006; 21(6): 396 - 403.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
L. M. Fabbri, F. Luppi, B. Beghe, and K. F. Rabe
Update in chronic obstructive pulmonary disease 2005.
Am. J. Respir. Crit. Care Med., May 15, 2006; 173(10): 1056 - 1065.
[Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH
Proc. Am. Thorac. Soc. Am. J. Respir. Cell Mol. Biol.
Copyright © 2005 American Thoracic Society 		  ATS Coding and Billing Quarterly