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Published ahead of print on August 11, 2005, doi:10.1164/rccm.200503-401PP

Am. J. Respir. Crit. Care Med., Volume 172, Number 10, November 2005, 1246-1252

A more recent version of this article appeared on November 15, 2005
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Submitted on March 14, 2005
Accepted on August 9, 2005

Computed Tomography in the Evaluation of Cystic Fibrosis Lung Disease

Alan S Brody1*, Harm A.W.M. Tiddens2, Robert G Castile3, Harvey O Coxson4, Pim A de Jong2, Jonathan Goldin5, Walter Huda6, Frederick R Long3, Michael McNitt-Gray5, Michael Rock7, Terry E Robinson8, and Scott D Sagel9

1 Department of Radiology, Cincinnati Children's Hospital Medical Center and The University of Cincinnati College of Medicine, Cincinnati, Ohio, USA, 2 Department of Pediatric Pulmonology, Erasmus MC-Sophia, Rotterdam, Rotterdam, The Netherlands, 3 The Children's Radiological Institute, Columbus Children's Hospital, Columbus, Ohio, USA, 4 Department of Radiology, Vancouver General Hospital, Vancouver, British Columbia, Canada, 5 Department of Radiology, David Geffen School of Medicine at University of California Los Angeles, Los Angeles, California, USA, 6 Department of Radiology, State University of New York Upstate Medical University, Syracuse, New York, USA, 7 University of Wisconsin, Madison, Wisconsin, USA, 8 Division of Pediatric Pulmonology, Packard Children's Hospital at Stanford, Palo Alto, California, USA, 9 Children's Hospital of Denver, Denver, Colorado, USA

* To whom correspondence should be addressed. E-mail: alan.brody{at}cchmc.org.

The first report of computed tomography (CT) scanning to monitor cystic fibrosis (CF) related lung disease was published in 1986 [1]. Further publications followed, but in general there was little interest in this technique until recently. Two factors in particular have led to this increased interest. First is an increasing realization that pulmonary function tests, long the mainstay of CF evaluation, often underestimate the presence and severity of mild and moderate lung disease. Second is the need for more sensitive outcome measures to assess new therapies. This had led to new interest and a series of important publications. The goal of this Pulmonary Perspective is to present the current status of CT scanning in CF.
Key words: cystic fibrosis, tomography X-ray computed, research design, radiation effects




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