help button home button
AJRCCM
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH
Published ahead of print on June 30, 2005, doi:10.1164/rccm.200502-315OC

Am. J. Respir. Crit. Care Med., Volume 172, Number 8, October 2005, 1037-1040

A more recent version of this article appeared on October 15, 2005
This Article
Right arrow Full Text (PDF)
Right arrow All Versions of this Article:
200502-315OCv1
172/8/1037    most recent
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Xatzipsalti, M.
Right arrow Articles by Papadopoulos, N. G
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Xatzipsalti, M.
Right arrow Articles by Papadopoulos, N. G

Submitted on February 28, 2005
Accepted on June 27, 2005

Rhinovirus Viremia in Children with Respiratory Infections

Maria Xatzipsalti1, Serena Kyrana1, Mariza Tsolia1, Stelios Psarras1, Apostolos Bossios1, Vasile Laza-Stanca2, Sebastian Johnston2, and Nikolaos G Papadopoulos1*

1 Department of Allergy, 2nd Pediatric Clinic, University of Athens, Athens, Greece, 2 National Heart and Lung Institute, Imperial College London, London, United Kingdom

* To whom correspondence should be addressed. E-mail: ngp{at}allergy.gr.

Rationale: Viremia has been implicated in many viral infections, however, viremia due to rhinovirus (RV, rhinoviremia) has been considered not to occur in normal individuals. Objective: To evaluate whether RV enter the bloodstream and identify the possible risk factors. Methods: Nasopharyngeal washes (NPW) of 221 children with respiratory infections were examined for the presence of RV by polymerase chain reaction (RT-PCR). Blood from 88 children, whose NPW was RV-positive, and 31 of RV-negative controls, was subsequently examined for the presence of RV in the blood by semi-nested RT-PCR. Rhinoviremia was then correlated with clinical characteristics of the disease. Results: RV was detected in the blood of 10/88 NPW RV-positive cases (11.4%): 7/28 of children with asthma exacerbations (25.0%), 2/26 with common cold (7.7%), 1/25 with bronchiolitis (4.0%) and 0/9 with pneumonia (0%). All NPW RV-negative cases were negative in the blood. The proportion of rhinoviremia in children with asthma exacerbation was significantly higher compared to children suffering from the other diseases (25% vs 5%, p=0.01). Significant risk factors were: sampling ≤ 24 hours from symptom initiation, personal history of asthma and male sex. Age, fever, family and personal history of atopy did not affect the presence of RV in the blood. Conclusions: Viremia may occur during RV respiratory infections in normal children and rather common in the early course of acute asthma exacerbations, suggesting that rhinoviremia may be involved in asthma exacerbation pathogenesis.
Key words: rhinovirus, viremia, respiratory infections, asthma, common cold




This article has been cited by other articles:


Home page
 Mult SclerHome page
M Kneider, T Bergstrom, C Gustafsson, N Nenonen, C Ahlgren, S Nilsson, and O Andersen
Sequence analysis of human rhinovirus aspirated from the nasopharynx of patients with relapsing-remitting MS
Multiple Sclerosis, April 1, 2009; 15(4): 437 - 442.
[Abstract] [PDF]

Home page
 Clin. Microbiol. Rev.Home page
J. B. Mahony
Detection of Respiratory Viruses by Molecular Methods
Clin. Microbiol. Rev., October 1, 2008; 21(4): 716 - 747.
[Abstract] [Full Text] [PDF]

Home page
 Arch Otolaryngol Head Neck SurgHome page
M. Nonaka, N. Ogihara, A. Fukumoto, A. Sakanushi, R. Pawankar, and T. Yagi
Combined Stimulation of Nasal Polyp Fibroblasts With Poly IC, Interleukin 4, and Tumor Necrosis Factor {alpha} Potently Induces Production of Thymus- and Activation-Regulated Chemokine
Arch Otolaryngol Head Neck Surg, June 1, 2008; 134(6): 630 - 635.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
A. Bush
Update in Pediatric Lung Disease 2007
Am. J. Respir. Crit. Care Med., April 1, 2008; 177(7): 686 - 695.
[Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
A. Bush
Update in Pediatric Lung Disease 2006
Am. J. Respir. Crit. Care Med., March 15, 2007; 175(6): 532 - 540.
[Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
A. M. Singh, P. E. Moore, J. E. Gern, R. F. Lemanske Jr., and T. V. Hartert
Bronchiolitis to Asthma: A Review and Call for Studies of Gene-Virus Interactions in Asthma Causation
Am. J. Respir. Crit. Care Med., January 15, 2007; 175(2): 108 - 119.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
K. Niimi, K. Asano, Y. Shiraishi, T. Nakajima, M. Wakaki, J. Kagyo, T. Takihara, Y. Suzuki, K. Fukunaga, T. Shiomi, et al.
TLR3-Mediated Synthesis and Release of Eotaxin-1/CCL11 from Human Bronchial Smooth Muscle Cells Stimulated with Double-Stranded RNA
J. Immunol., January 1, 2007; 178(1): 489 - 495.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
A. Bush
Update in pediatrics 2005.
Am. J. Respir. Crit. Care Med., March 15, 2006; 173(6): 585 - 592.
[Full Text] [PDF]

Home page
 JWatch Infect. DiseasesHome page
Rhinoviremia Common in Children with Asthma
Journal Watch Infectious Diseases, November 18, 2005; 2005(1118): 9 - 9.
[Full Text]

Home page
 Am. J. Respir. Crit. Care Med.Home page
S. T. Holgate
Exacerbations: The Asthma Paradox
Am. J. Respir. Crit. Care Med., October 15, 2005; 172(8): 941 - 943.
[Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH
Proc. Am. Thorac. Soc. Am. J. Respir. Cell Mol. Biol.
Copyright © 2005 American Thoracic Society 		  Red In Translatin