help button home button
AJRCCM
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH
Published ahead of print on September 1, 2005, doi:10.1164/rccm.200502-235PP

Am. J. Respir. Crit. Care Med., Volume 173, Number 1, January 2006, 16-22

A more recent version of this article appeared on January 1, 2006
This Article
Right arrow Full Text (PDF)
Right arrow All Versions of this Article:
200502-235PPv1
173/1/16    most recent
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Schwartz, A. G
Right arrow Articles by Ruckdeschel, J. C
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Schwartz, A. G
Right arrow Articles by Ruckdeschel, J. C

Submitted on February 14, 2005
Accepted on August 31, 2005

Familial Lung Cancer: Genetic Susceptibility and Relationship to COPD

Ann G Schwartz1* and John C Ruckdeschel1

1 Population Studies and Prevention Program, Karmanos Cancer Institute and Department of Internal Medicine, Wayne State University, Detroit, MI, USA

* To whom correspondence should be addressed. E-mail: schwarta{at}med.wayne.edu.

Lung cancer continues to be the leading cause of cancer death and while most lung cancer is attributable to cigarette smoking, underlying genetic susceptibility is suggested by studies demonstrating familial aggregation. The first family linkage study of lung cancer has identified linkage of lung, laryngeal and pharyngeal cancer in families to a region on chromosome 6q23-25. Because lung cancer and COPD are known to aggregate in families beyond shared risk associated with smoking, the linkage results are compared and contrasted with results from genome-wide linkage and association studies and candidate gene studies searching for genes for lung cancer, lung function and COPD. Linkage on chromosome 6q to both lung cancer and lung function and on 12 to lung cancer, COPD and lung function, along with overlap in candidate genes for these outcomes, suggests that future research into underlying genetic mechanisms of lung disease would benefit from broadening the collection of family history data and better defining the "high risk" population. As familial risk of lung disease is better defined, referral into screening programs and prevention trials can be better targeted to reach families with both a history of lung cancer and COPD.
Key words: Lung cancer,COPD, Genetics, Linkage




This article has been cited by other articles:


Home page
 J. Epidemiol. Community HealthHome page
K Hemminki, X Li, K Sundquist, and J Sundquist
Familial risks for chronic obstructive pulmonary disease among siblings based on hospitalisations in Sweden
J Epidemiol Community Health, May 1, 2008; 62(5): 398 - 401.
[Abstract] [Full Text] [PDF]

Home page
 CarcinogenesisHome page
E.L. Crawford, T. Blomquist, D.N. Mullins, Y. Yoon, D.R. Hernandez, M. Al-Bagdhadi, J. Ruiz, J. Hammersley, and J.C. Willey
CEBPG regulates ERCC5/XPG expression in human bronchial epithelial cells and this regulation is modified by E2F1/YY1 interactions
Carcinogenesis, December 1, 2007; 28(12): 2552 - 2559.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
D. H. Au, J. W. Chien, and C. L. Bryson
A Major Cause of Death in COPD and Risk Factors for Lung Cancer a Dilemma or a Mistake?
Am. J. Respir. Crit. Care Med., September 15, 2007; 176(6): 625 - 625.
[Full Text] [PDF]

Home page
 Ann. Thorac. Surg.Home page
Y. Sekine, Y. Yamada, M. Chiyo, T. Iwata, T. Nakajima, K. Yasufuku, M. Suzuki, and T. Fujisawa
Association of Chronic Obstructive Pulmonary Disease and Tumor Recurrence in Patients With Stage IA Lung Cancer After Complete Resection
Ann. Thorac. Surg., September 1, 2007; 84(3): 946 - 950.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
S. Dubey and C. A. Powell
Update in Lung Cancer 2006
Am. J. Respir. Crit. Care Med., May 1, 2007; 175(9): 868 - 874.
[Full Text] [PDF]

Home page
 Clin. Cancer Res.Home page
C. A. Granville, N. Warfel, J. Tsurutani, M. C. Hollander, M. Robertson, S. D. Fox, T. D. Veenstra, H. J. Issaq, R. I. Linnoila, and P. A. Dennis
Identification of a Highly Effective Rapamycin Schedule that Markedly Reduces the Size, Multiplicity, and Phenotypic Progression of Tobacco Carcinogen-Induced Murine Lung Tumors
Clin. Cancer Res., April 1, 2007; 13(7): 2281 - 2289.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Epidemiol. Biomarkers Prev.Home page
L. E. Mechanic, E. D. Bowman, J. A. Welsh, M. A. Khan, N. Hagiwara, L. Enewold, P. G. Shields, L. Burdette, S. Chanock, and C. C. Harris
Common Genetic Variation in TP53 Is Associated with Lung Cancer Risk and Prognosis in African Americans and Somatic Mutations in Lung Tumors
Cancer Epidemiol. Biomarkers Prev., February 1, 2007; 16(2): 214 - 222.
[Abstract] [Full Text] [PDF]

Home page
 MutagenesisHome page
A. M. Knaapen, N. Gungor, R. P. F. Schins, P. J. A. Borm, and F. J. Van Schooten
Neutrophils and respiratory tract DNA damage and mutagenesis: a review
Mutagenesis, July 1, 2006; 21(4): 225 - 236.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
J. R. Jett and Y. E. Miller
Update in lung cancer 2005.
Am. J. Respir. Crit. Care Med., April 1, 2006; 173(7): 695 - 697.
[Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH
Proc. Am. Thorac. Soc. Am. J. Respir. Cell Mol. Biol.
Copyright © 2005 American Thoracic Society 		  ATS Sleep Tracings Quiz