Published ahead of print on September 22, 2005, doi:10.1164/rccm.200502-230OC Am. J. Respir. Crit. Care Med., Volume 172, Number 12, December 2005, 1569-1574 A more recent version of this article appeared on December 15, 2005
Submitted on February 14, 2005 Effect of Ductus Ligation on Cardiopulmonary Function in Premature BaboonsDonald C McCurnin1*,1 Southwest Foundation for Biomedical Research, San Antonio, TX, USA; Department of Pediatrics, University of Texas Health Science Center San Antonio, San Antonio, TX, USA, 2 Department of Pathology, University of Texas Health Science Center San Antonio, San Antonio, TX, USA, 3 Wilford Hall Medical Center, San Antonio, TX, USA, 4 Department of Cardiothoracic Surgery, University of Texas Health Science Center San Antonio, San Antonio, TX, USA, 5 Department of Obstetrics-Gynecology, University of Texas Health Science Center San Antonio, San Antonio, TX, USA, 6 Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, TX, USA, 7 Department of Pediatrics, University of California, Cardiovascular Research Institute, San Francisco, CA, USA * To whom correspondence should be addressed. E-mail: mccurnin{at}uthscsa.edu.
Rationale: The role of the patent ductus arteriosus in the development of chronic lung disease in surfactant-treated premature newborns remains unclear. Objective: To examine the effects of ductus ligation on cardiopulmonary function and lung histopathology in premature primates. Methods: Baboons were delivered at 125 days, (term=185 days) treated with surfactant and ventilated for 14 days. Serial echocardiograms and pulmonary function tests were performed. Animals were randomized to ligation (n = 12) or no ligation (CONTROLS, n = 13) on day of life 6. Necropsy was performed on day 14. Results: Compared to non-ligated controls, ligated animals had lower pulmonary to systemic flow ratios, higher systemic blood pressures and improved indices of right and left ventricular performance. The ligated animals tended to have better compliance and ventilation indices for the last 3 days of the study. There were no differences between the groups in proinflammatory tracheal cytokines (IL-6 and IL-8), static lung compliance, or lung histology. Conclusion: Although a persistent patent ductus arteriosus results in diminished cardiac function and increased ventilatory requirementsat the end of the second week of life, ligation on day 6 had no measureable effect on the histologic evolution of chronic lung injury in this 14-day baboon model. Key words: Chronic lung disease, Patent Ductus Arteriosus, Premature Newborn, Bronchopulmonary Dysplasia, BPD
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