help button home button
AJRCCM
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH
Published ahead of print on July 14, 2005, doi:10.1164/rccm.200501-098WS

Am. J. Respir. Crit. Care Med., Volume 172, Number 8, October 2005, 944-955

A more recent version of this article appeared on October 15, 2005
This Article
Right arrow Full Text (PDF)
Right arrow All Versions of this Article:
200501-098WSv1
172/8/944    most recent
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Wilkes, D. S
Right arrow Articles by Reynolds, H. Y
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Wilkes, D. S
Right arrow Articles by Reynolds, H. Y

Submitted on January 21, 2005
Accepted on July 14, 2005

Workshop on Lung Transplantation: Opportunities for Research and Clinical Advancement

David S Wilkes1, Thomas M Egan2, and Herbert Y Reynolds3*

1 Department of Medicine, Indiana University, School of Medicine, Indiannapolis, IN, USA, 2 Department of Surgery, University of North Carolina at Chapel Hill, Chapel Hill, N.C., USA, 3 Division of Lung Diseases, National Heart, Lung and Blood Institute, Bethesda, MD, United States

* To whom correspondence should be addressed. E-mail: reynoldh{at}nhlbi.nih.gov.

Lung transplantation is the only definitive therapy for many forms of endstage lung diseases. However, the success of lung transplantation is limited by many factors: 1) Too few lungs available for transplantation due to limited donors or injury to the donor lung; 2) current methods of preservation of excised lungs do not allow extended periods of time between procurement and implantation; 3) acute graft failure is more common with lungs than other solid organs, thus, contributing to poorer short-term survival following lung transplant compared with that for recipients of other organs; 4) lung transplant recipients are particularly vulnerable to pulmonary infections; and 5) chronic allograft dysfunction, manifest by bronchiolitis obliterans syndrome, is frequent and limits long-term survival. Scientific advances may provide significant improvements in the outcome of lung transplantation. The National Heart, Lung, and Blood Institute convened a Working Group of investigators on June 14 -15, 2004, in Bethesda, Maryland to identify opportunities for scientific advancement in lung transplantation, including basic and clinical research. This workshop provides a framework to identify critical issues related to clinical lung transplantation, and to delineate important areas for productive scientific investigation.
Key words: lung transplantation, ischemia-reperfusion injury, allograph dysfunction, obliterative bronchiolitis, infection, rejection




This article has been cited by other articles:


Home page
 ThoraxHome page
B. C Willis and Z. Borok
Epithelial-mesenchymal transition: potential role in obliterative bronchiolitis?
Thorax, September 1, 2009; 64(9): 742 - 743.
[Full Text] [PDF]

Home page
 Arterioscler. Thromb. Vasc. Bio.Home page
E. C. Keeley, B. Mehrad, and R. M. Strieter
Chemokines as Mediators of Neovascularization
Arterioscler Thromb Vasc Biol, November 1, 2008; 28(11): 1928 - 1936.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
L. Jarvinen, L. Badri, S. Wettlaufer, T. Ohtsuka, T. J. Standiford, G. B. Toews, D. J. Pinsky, M. Peters-Golden, and V. N. Lama
Lung Resident Mesenchymal Stem Cells Isolated from Human Lung Allografts Inhibit T Cell Proliferation via a Soluble Mediator
J. Immunol., September 15, 2008; 181(6): 4389 - 4396.
[Abstract] [Full Text] [PDF]

Home page
 J. Thorac. Cardiovasc. Surg.Home page
D. I. Sternberg, D. Shimbo, S. M. Kawut, J. Sarkar, G. Hurlitz, F. D'Ovidio, D. J. Lederer, J. S. Wilt, S. M. Arcasoy, D. J. Pinsky, et al.
Platelet activation in the postoperative period after lung transplantation
J. Thorac. Cardiovasc. Surg., March 1, 2008; 135(3): 679 - 684.
[Abstract] [Full Text] [PDF]

Home page
 Eur Respir JHome page
J. Sadovski, T. Kuchenbuch, C. Ruppert, A. Fehrenbach, M. Hirschburger, W. Padberg, A. Gunther, J. M. Hohlfeld, H. Fehrenbach, and V. Grau
Keratinocyte growth factor prevents intra-alveolar oedema in experimental lung isografts
Eur. Respir. J., January 1, 2008; 31(1): 21 - 28.
[Abstract] [Full Text] [PDF]

Home page
 Proc Am Thorac SocHome page
J. F. McDyer
Human and Murine Obliterative Bronchiolitis in Transplant
Proceedings of the ATS, January 1, 2007; 4(1): 37 - 43.
[Abstract] [Full Text] [PDF]

Home page
 Proc Am Thorac SocHome page
J. D. Lande, J. Patil, N. Li, T. R. Berryman, R. A. King, and M. I. Hertz
Novel Insights into Lung Transplant Rejection by Microarray Analysis
Proceedings of the ATS, January 1, 2007; 4(1): 44 - 51.
[Abstract] [Full Text] [PDF]

Home page
 J. Leukoc. Biol.Home page
A. Schmidt, J. Sucke, G. Fuchs-Moll, P. Freitag, M. Hirschburger, A. Kaufmann, H. Garn, W. Padberg, and V. Grau
Macrophages in experimental rat lung isografts and allografts: infiltration and proliferation in situ
J. Leukoc. Biol., January 1, 2007; 81(1): 186 - 194.
[Abstract] [Full Text] [PDF]

Home page
 FASEB J.Home page
H. Liu, L. Liu, B. S. Fletcher, and G. A. Visner
Sleeping Beauty-based gene therapy with indoleamine 2,3-dioxygenase inhibits lung allograft fibrosis
FASEB J, November 1, 2006; 20(13): 2384 - 2386.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
L. F. Angel, D. J. Levine, M. I. Restrepo, S. Johnson, E. Sako, A. Carpenter, J. Calhoon, J. E. Cornell, S. G. Adams, G. B. Chisholm, et al.
Impact of a Lung Transplantation Donor-Management Protocol on Lung Donation and Recipient Outcomes
Am. J. Respir. Crit. Care Med., September 15, 2006; 174(6): 710 - 716.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
N. H. Yip, D. J. Lederer, S. M. Kawut, J. S. Wilt, F. D'Ovidio, Y. Wang, E. Dwyer, J. R. Sonett, and S. M. Arcasoy
Immunoglobulin G Levels before and after Lung Transplantation
Am. J. Respir. Crit. Care Med., April 15, 2006; 173(8): 917 - 921.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
M. Estenne and R. M. Kotloff
Update in transplantation 2005.
Am. J. Respir. Crit. Care Med., March 15, 2006; 173(6): 593 - 598.
[Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
H. Liu, L. Liu, B. S. Fletcher, and G. A. Visner
Novel Action of Indoleamine 2,3-Dioxygenase Attenuating Acute Lung Allograft Injury
Am. J. Respir. Crit. Care Med., March 1, 2006; 173(5): 566 - 572.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
J. B. Orens, J. F. McDyer, and R. E. Girgis
Azithromycin in Bronchiolitis Obliterans: Is the Evidence Strong Enough?
Am. J. Respir. Crit. Care Med., February 15, 2006; 173(4): 466 - 466.
[Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
D. S. Wilkes
Lung Transplantation: Opportunities for Research and Clinical Advancement
Am. J. Respir. Crit. Care Med., February 15, 2006; 173(4): 467 - 467.
[Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
C. M. Magro, A. L. Pope-Harman, A. E. Abbas, and P. Ross Jr
Lung Transplantation: Opportunities for Research and Clinical Advancement
Am. J. Respir. Crit. Care Med., February 15, 2006; 173(4): 466a - 467.
[Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH
Proc. Am. Thorac. Soc. Am. J. Respir. Cell Mol. Biol.
Copyright © 2005 American Thoracic Society 		  Red In Translatin