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Published ahead of print on November 4, 2005, doi:10.1164/rccm.200501-052OC

Am. J. Respir. Crit. Care Med., Volume 173, Number 4, February 2006, 448-452

A more recent version of this article appeared on February 15, 2006
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Submitted on January 12, 2005
Accepted on November 2, 2005

Improvement of Lung Compliance During Postnatal Adaptation Correlates with Airway Sodium Transport

Otto Helve1*, Sture Andersson1, Turkka Kirjavainen1, and Olli M Pitkanen2

1 Division of Neonatology, University of Helsinki, Hospital for Children and Adolescents, Helsinki, Finland, 2 Division of Cardiology, University of Helsinki, Hospital for Children and Adolescents, Helsinki, Finland

* To whom correspondence should be addressed. E-mail: otto.helve{at}hus.fi.

Rationale: Fetal lung liquid secretion is coupled with chloride transport into the lung lumen. The postnatal clearance of lung liquid is dependent on osmotic force generated by active sodium absorption. Objective: To study the interaction between airway epithelial sodium transport and postnatal lung function. Methods: We determined lung compliance and nasal transepithelial potential difference, as a measure of airway ion transport, and epithelial sodium channel (ENaC) gene expression in 41 healthy newborn infants during the first 50 hours after birth. Measurements and Main Results: Lung compliance improved significantly during the study period, whereas nasal potential difference remained constant. There was a significant decrease in the expressions of {beta}- and {gamma}-subunits of the epithelial sodium channel. A positive correlation existed between amiloride-sensitive nasal potential difference measured at 1-4 hours of age and lung compliance at 21-27 hours of age. We found no correlation between the molecular data and functional measurements. Conclusions: An important part of pulmonary adaptation takes place during the first hour after birth. The improvement of lung compliance continues over the first postnatal days and coincides with down-regulation of ENaC {beta}- and {gamma}-subunit expression.
Key words: Ion transport, epithelium, lung compliance, postnatal adaptation, ENaC




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