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Published ahead of print on February 11, 2005, doi:10.1164/rccm.200501-046OC

Am. J. Respir. Crit. Care Med., Volume 171, Number 10, May 2005, 1178-1184

A more recent version of this article appeared on May 15, 2005
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Submitted on January 14, 2005
Accepted on February 7, 2005

Measurement of Hypoxia-related Parameters in Bronchial Mucosa by use of Optical Spectroscopy

Martin P.L. Bard1, Arjen Amelink2, Vincent Noordhoek Hegt3, Wilfried J Graveland4, Henricus J.C.M. Sterenborg2, Henk C Hoogsteden1, and Joachim G.J.V. Aerts5*

1 Department of Respiratory Diseases, Erasmus Medical Centre, Rotterdam, The Netherlands, 2 Center for Optical Diagnostics and Therapy, Department of Radiation Oncology, Erasmus Medical Centre, Rotterdam, The Netherlands, 3 Department of Pathology, Sint Franciscus Hospital, Rotterdam, The Netherlands, 4 Department of Statistics, Erasmus Medical Centre, Rotterdam, The Netherlands, 5 Department of Respiratory Diseases, Erasmus Medical Centre, Rotterdam, The Netherlands; Department of Respiratory Diseases, Sint Franciscus Hospital, Rotterdam, The Netherlands

* To whom correspondence should be addressed. E-mail: j.aerts{at}sfg.nl.

Rationale: Tumor hypoxia has both prognostic and therapeutic consequences for solid tumors. We developed a novel non-invasive technique, differential path-length spectroscopy (DPS), which allows the measurement of hypoxia-related parameters in the superficial microvasculature of tissue. Objectives: The aim of this study was to measure the microvascular oxygenation of histologically normal endobronchial mucosa and of neoplastic lesions during bronchoscopy using DPS. Methods: Sixty-four patients with known or suspected malignancies of the lung were studied. One hundred and five endobronchial lesions (38 histologically normal, 37 metaplastic/mild dysplastic lesions and 30 invasive carcinomas) were detected by white and/or autofluorescence bronchoscopy and measured using DPS. Results: We observed that bronchial tumors are characterized by a lower blood oxygen saturation and a higher blood content than normal mucosa. No differences were observed between normal and metaplastic/mild dysplastic mucosa. Conclusion: DPS is a new optical technique allowing the non-invasive study of endobronchial tumor hypoxia.
Key words: Lung, Cancer, Pre-malignant, Optical Spectroscopy, Hypoxia




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