Published ahead of print on June 16, 2005, doi:10.1164/rccm.200412-1743PP
Am. J. Respir. Crit. Care Med., Volume 172, Number 9, November 2005, 1078-1089
A more recent version of this article appeared on November 1, 2005
Submitted on December 24, 2004
Accepted on June 9, 2005
Chlamydophila pneumoniae and Mycoplasma pneumoniae: a Role in Asthma Pathogenesis?
Sebastian L Johnston1* and Richard J Martin2
1 Department of Respiratory Medicine, National Heart and Lung and Wright Fleming Institute of Infection and Immunity, Imperial College London, London, United Kingdom,
2 National Jewish Medical and Research Center and University of Colorado, Denver, CO, USA
* To whom correspondence should be addressed. E-mail: s.johnston{at}imperial.ac.uk.
The potential role of atypical bacterial infection in the pathogenesis of asthma is a subject of continuing debate. There is an increasing body of literature concerning the association between the atypical bacteria Chlamydophila pneumoniae and Mycoplasma pneumoniae and asthma pathogenesis; however, many studies investigating such a link have been uncontrolled and have provided conflicting evidence, in part due to the difficulty in accurately diagnosing infection with these atypical pathogens. This paper reviews the evidence for an association between atypical bacterial respiratory pathogens and the pathogenesis of asthma, and discusses the biologic mechanisms that could account for such a link. The possible role of antibacterial therapy in the management of asthma and the need for well-designed studies to investigate this is also discussed.
Key words: asthma, Chlamydophila pneumoniae, Mycoplasma pneumoniae, macrolides, ketolides
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