Published ahead of print on April 7, 2005, doi:10.1164/rccm.200411-1555OC Am. J. Respir. Crit. Care Med., Volume 172, Number 1, July 2005, 67-73 A more recent version of this article appeared on July 1, 2005
Submitted on November 21, 2004 Variation in ITGB3 is Associated with Asthma and Sensitization to Mold Allergen in Four PopulationsLauren A Weiss1,1 Department of Human Genetics, The University of Chicago, Chicago, IL, USA, 2 Department of Pediatrics, The University of Chicago, Chicago, IL, USA, 3 Department of Medicine, University of Wisconsin, Madison, WI, USA, 4 School of Medicine, University of South Dakota, Sioux Falls, SD, USA, 5 Department of Pediatrics, University of Wisconsin, Madison, WI, USA, 6 Department of Medicine, University of Chicago, Chicago, IL, USA * To whom correspondence should be addressed. E-mail: c-ober{at}genetics.bsd.uchicago.edu.
Rationale: Recent genetic studies have implicated integrins in asthma and atopy susceptibility. We therefore evaluated the integrin Key words: Asthma, Hypersensitivity, Genetics, Association, Integrins
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3 gene (ITGB3), an integrin gene within an asthma linkage peak on chromosome 17, as a candidate for susceptibility to asthma- and atopy-related phenotypes. Methods and Measurements: We genotyped and performed association tests on 19 SNPs in ITGB3 in the Hutterites, a founder population, and in three outbred replication populations. Main Results: Variation in ITGB3 was strongly associated with susceptibility to bronchial hyperresponsiveness (BHR) and protection from allergic sensitization to mold allergens in this population. Three independent case-control populations representing Caucasians and African Americans were used to replicate this finding, also revealing ITGB3 alleles that are associated with asthma susceptibility and protection from mold allergen sensitization. Conclusions: This study provides evidence that ITGB3 plays a role in the pathogenesis of asthma and sensitization to mold allergens .
