help button home button
AJRCCM
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH
Published ahead of print on May 5, 2005, doi:10.1164/rccm.200411-1486OC

Am. J. Respir. Crit. Care Med., Volume 172, Number 3, August 2005, 329-333

A more recent version of this article appeared on August 1, 2005
This Article
Right arrow Full Text (PDF)
Right arrow All Versions of this Article:
200411-1486OCv1
172/3/329    most recent
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by van Diemen, C. C
Right arrow Articles by Boezen, H. M. M
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by van Diemen, C. C
Right arrow Articles by Boezen, H. M. M

Submitted on November 8, 2004
Accepted on April 30, 2005

A Desintegrin and Metalloprotease 33 Polymorphisms and Lung Function Decline in the Population

Cleo C van Diemen1, Dirkje S Postma2, Judith M Vonk1, Marcel Bruinenberg3, Jan P Schouten1, and H. Marike M Boezen1*

1 Department of Epidemiology and Bioinformatics, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands, 2 Department of Pulmonology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands, 3 Department of Medical Biology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands

* To whom correspondence should be addressed. E-mail: h.m. boezen{at}med.umcg.nl.

Rationale: ADAM33 (A Desintegrin and Metalloprotease 33) has been identified as a susceptibility gene for asthma and single nucleotide polymorphisms (SNPs) in this gene have been associated with excess decline of lung function in asthmatics. Objectives: To assess whether SNPs in ADAM33 are associated with accelerated lung function loss in the general population and with chronic obstructive pulmonary disease (COPD). Methods: We have collected DNA from subjects of the Vlagtwedde/Vlaardingen cohort participating in the last survey in 1989/1990 after a follow up of 25 years. Information was collected every 3 years, including lung function measurements. We defined COPD as GOLD stage 2 or higher at the last survey. 1390 subjects from the cohort were genotyped for the following SNPs in ADAM33: F+1, Q-1, S_1, S_2, T_1, T_2, V_4, ST+5. Differences in prevalence of SNPs were analyzed with chi-square tests. Linear mixed effects models were used to analyze FEV1 decline according to genotype. Measurements and main results: In the whole population mean adjusted decline was 18.7 and 12.7 ml/y in females and males respectively. Individuals homozygous for minor alleles of SNPs S_2 and Q-1 and heterozygous for SNP S_1 had a significantly accelerated decline in FEV1 of respectively 4.9, 9.6 and 3.6 ml/y compared with wild type. We found a significantly higher prevalence of SNPs F+1, S_1, S_2 and T_2 in subjects with COPD. Conclusions: We demonstrated that SNPs in ADAM33 are associated with accelerated lung function decline in the general population. These SNPs are also risk factors for COPD.
Key words: COPD, FEV1, single nucleotide polymorphism, genetics, ADAM33




This article has been cited by other articles:


Home page
 Am. J. Respir. Crit. Care Med.Home page
M. Siedlinski, D. S. Postma, C. C. van Diemen, A. Blokstra, H. A. Smit, and H. M. Boezen
Lung Function Loss, Smoking, Vitamin C Intake, and Polymorphisms of the Glutamate-Cysteine Ligase Genes
Am. J. Respir. Crit. Care Med., July 1, 2008; 178(1): 13 - 19.
[Abstract] [Full Text] [PDF]

Home page
 J. Med. Genet.Home page
M Siedlinski, C C van Diemen, D S Postma, and H M Boezen
Heme oxygenase 1 variations and lung function decline in smokers: proof of replication
J. Med. Genet., June 1, 2008; 45(6): 400 - 400.
[Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
A. Bush
Update in Pediatric Lung Disease 2007
Am. J. Respir. Crit. Care Med., April 1, 2008; 177(7): 686 - 695.
[Full Text] [PDF]

Home page
 Eur Respir JHome page
T. R. Bai, J. M. Vonk, D. S. Postma, and H. M. Boezen
Severe exacerbations predict excess lung function decline in asthma
Eur. Respir. J., September 1, 2007; 30(3): 452 - 456.
[Abstract] [Full Text] [PDF]

Home page
 Eur Respir JHome page
C. M. Lloyd and D. S. Robinson
Allergen-induced airway remodelling
Eur. Respir. J., May 1, 2007; 29(5): 1020 - 1032.
[Abstract] [Full Text] [PDF]

Home page
 Postgrad. Med. J.Home page
F. Sampsonas, A. Kaparianos, D. Lykouras, K. Karkoulias, and K. Spiropoulos
DNA sequence variations of metalloproteinases: their role in asthma and COPD
Postgrad. Med. J., April 1, 2007; 83(978): 244 - 250.
[Abstract] [Full Text] [PDF]

Home page
 ThoraxHome page
M. M E Gosman, H Marike Boezen, C. C van Diemen, J. B Snoeck-Stroband, T. S Lapperre, P. S Hiemstra, N. H T ten Hacken, J. Stolk, D. S Postma, and the GLUCOLD Study Group
A disintegrin and metalloprotease 33 and chronic obstructive pulmonary disease pathophysiology
Thorax, March 1, 2007; 62(3): 242 - 247.
[Abstract] [Full Text] [PDF]

Home page
 Eur Respir JHome page
H. M. Boezen and D. S. Postma
Tumour necrosis factor and lymphotoxin A polymorphisms: a relationship with COPD and its progression?
Eur. Respir. J., January 1, 2007; 29(1): 8 - 10.
[Full Text] [PDF]

Home page
 ERRHome page
CleoC. van Diemen, DirkjeS. Postma, JudithM. Vonk, M. Bruinenberg, JanP. Schouten, and H. Marike Boezen
A Disintegrin and Metalloprotease 33 polymorphisms and lung function decline in the general population
Eur. Respir. Rev., December 1, 2006; 15(101): 204 - 206.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
M. Kraft
Asthma and chronic obstructive pulmonary disease exhibit common origins in any country!
Am. J. Respir. Crit. Care Med., August 1, 2006; 174(3): 238 - 240.
[Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
P. J. Barnes
Against the dutch hypothesis: asthma and chronic obstructive pulmonary disease are distinct diseases.
Am. J. Respir. Crit. Care Med., August 1, 2006; 174(3): 240 - 243.
[Full Text] [PDF]

Home page
 Proc Am Thorac SocHome page
S. T. Holgate, Y. Yang, H.-M. Haitchi, R. M. Powell, J. W. Holloway, H. Yoshisue, Y. Y. Pang, J. Cakebread, and D. E. Davies
The Genetics of Asthma: ADAM33 as an Example of a Susceptibility Gene.
Proceedings of the ATS, July 1, 2006; 3(5): 440 - 443.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
L. M. Fabbri, F. Luppi, B. Beghe, and K. F. Rabe
Update in chronic obstructive pulmonary disease 2005.
Am. J. Respir. Crit. Care Med., May 15, 2006; 173(10): 1056 - 1065.
[Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
S. E. Wenzel and R. Covar
Update in asthma 2005.
Am. J. Respir. Crit. Care Med., April 1, 2006; 173(7): 698 - 706.
[Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
J.-Y. Lee, S.-W. Park, H. K. Chang, H. Y. Kim, T. Rhim, J.-H. Lee, A.-S. Jang, E.-S. Koh, and C.-S. Park
A Disintegrin and Metalloproteinase 33 Protein in Patients with Asthma: Relevance to Airflow Limitation
Am. J. Respir. Crit. Care Med., April 1, 2006; 173(7): 729 - 735.
[Abstract] [Full Text] [PDF]

Home page
 Eur Respir JHome page
C. Boxall, S. T. Holgate, and D. E. Davies
The contribution of transforming growth factor-{beta} and epidermal growth factor signalling to airway remodelling in chronic asthma
Eur. Respir. J., January 1, 2006; 27(1): 208 - 229.
[Abstract] [Full Text] [PDF]

Home page
 ThoraxHome page
Spoken sessions
Thorax, December 1, 2005; 60(suppl_2): ii4 - ii52.
[Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH
Proc. Am. Thorac. Soc. Am. J. Respir. Cell Mol. Biol.
Copyright © 2005 American Thoracic Society 		  ATS Best of the Web