help button home button
AJRCCM
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH
Published ahead of print on June 23, 2005, doi:10.1164/rccm.200410-1335OC

Am. J. Respir. Crit. Care Med., Volume 172, Number 7, October 2005, 885-891

A more recent version of this article appeared on October 1, 2005
This Article
Right arrow Full Text (PDF)
Right arrow All Versions of this Article:
200410-1335OCv1
172/7/885    most recent
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Kulich, M.
Right arrow Articles by Ramsey, B.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Kulich, M.
Right arrow Articles by Ramsey, B.

Submitted on October 8, 2004
Accepted on June 19, 2005

Disease-Specific Reference Equations for Lung Function in Patients with Cystic Fibrosis

Michal Kulich1*, Margaret Rosenfeld2, Jonathan Campbell3, Richard Kronmal4, Ron L Gibson2, Christopher H Goss5, and Bonnie Ramsey6

1 Department of Probability and Statistics, Charles University, Faculty of Mathematics and Physics, Prague, Czech Republic, 2 Division of Pulmonary Medicine, Department of Pediatrics, University of Washington, Seattle, WA, USA, 3 Department of Pharmacy, University of Washington, Seattle, WA, USA, 4 Department of Biostatistics, University of Washington, Seattle, WA, USA, 5 Cystic Fibrosis Therapeutic Development Network Coordinating Center, Children's Hospital and Regional Medical Center, Seattle, WA, USA; Division of Pulmonary and Critical Care Medicine, Department of Medicine, University of Washington, Seattle, WA, USA, 6 Division of Pulmonary Medicine, Department of Pediatrics, University of Washington, Seattle, WA, USA; Cystic Fibrosis Therapeutic Development Network Coordinating Center, Children's Hospital and Regional Medical Center, Seattle, WA, USA

* To whom correspondence should be addressed. E-mail: kulich{at}karlin.mff.cuni.cz.

Rationale: Forced expiratory volume in one second (FEV1), an important measure of pulmonary disease severity in cystic fibrosis (CF) patients, is frequently expressed as a percentage of a predicted value derived from a healthy reference population. There are limitations to comparing the lung function of a CF patient to that of healthy controls, and potential advantages to comparing it to that of other CF patients. Objective: To estimate CF-specific percentiles of FEV1 as functions of height, age, and gender. Methods: We used 287,108 FEV1 observations among >21,000 CF patients in the CF Foundation National Patient Registry between 1994 and 2001. The percentiles were estimated using quantile regression methods. Results: FEV1 percentile "growth grids" are presented allowing comparison of an individual's FEV1 to that of CF patients of the same gender, age and height. Their potential uses in clinical practice and research are illustrated. Conclusions: CF-specific reference equations allow individual patients' FEV1 to be placed in the context of the distribution of lung function of their peers with CF, and should improve generalizability of CF clinical trials by setting entry criteria that are equitable across gender and age ranges. They may serve as a useful adjunct to conventional reference equations.
Key words: cystic fibrosis, lung function, percentile, reference equations




This article has been cited by other articles:


Home page
 Am. J. Respir. Cell Mol. Bio.Home page
C. Guilbault, G. Wojewodka, Z. Saeed, M. Hajduch, E. Matouk, J. B. De Sanctis, and D. Radzioch
Cystic Fibrosis Fatty Acid Imbalance Is Linked to Ceramide Deficiency and Corrected by Fenretinide
Am. J. Respir. Cell Mol. Biol., July 1, 2009; 41(1): 100 - 106.
[Abstract] [Full Text] [PDF]

Home page
 Hum Mol GenetHome page
L. A. Bremer, S. M. Blackman, L. L. Vanscoy, K. E. McDougal, A. Bowers, K. M. Naughton, D. J. Cutler, and G. R. Cutting
Interaction between a novel TGFB1 haplotype and CFTR genotype is associated with improved lung function in cystic fibrosis
Hum. Mol. Genet., July 15, 2008; 17(14): 2228 - 2237.
[Abstract] [Full Text] [PDF]

Home page
 JAMAHome page
J. M. Collaco, L. Vanscoy, L. Bremer, K. McDougal, S. M. Blackman, A. Bowers, K. Naughton, J. Jennings, J. Ellen, and G. R. Cutting
Interactions Between Secondhand Smoke and Genes That Affect Cystic Fibrosis Lung Disease
JAMA, January 30, 2008; 299(4): 417 - 424.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
L. L. Vanscoy, S. M. Blackman, J. M. Collaco, A. Bowers, T. Lai, K. Naughton, M. Algire, R. McWilliams, S. Beck, J. Hoover-Fong, et al.
Heritability of Lung Disease Severity in Cystic Fibrosis
Am. J. Respir. Crit. Care Med., May 15, 2007; 175(10): 1036 - 1043.
[Abstract] [Full Text] [PDF]

Home page
 Proc Am Thorac SocHome page
M. P. Boyle
Strategies for Identifying Modifier Genes in Cystic Fibrosis
Proceedings of the ATS, January 1, 2007; 4(1): 52 - 57.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
M. D. Schluchter, M. W. Konstan, M. L. Drumm, J. R. Yankaskas, and M. R. Knowles
Classifying Severity of Cystic Fibrosis Lung Disease Using Longitudinal Pulmonary Function Data
Am. J. Respir. Crit. Care Med., October 1, 2006; 174(7): 780 - 786.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
F. J. Accurso
Update in cystic fibrosis 2005.
Am. J. Respir. Crit. Care Med., May 1, 2006; 173(9): 944 - 947.
[Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
F. Stanke, M. Ballmann, and B. Tummler
Cystic Fibrosis Disease-specific Centiles in 2000 and 2005.
Am. J. Respir. Crit. Care Med., May 1, 2006; 173(9): 1047 - 1047.
[Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
M. Kulich, M. Rosenfeld, and B. Ramsey
Cystic Fibrosis Disease-specific Centiles in 2000 and 2005
Am. J. Respir. Crit. Care Med., May 1, 2006; 173(9): 1047a - 1047a.
[Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH
Proc. Am. Thorac. Soc. Am. J. Respir. Cell Mol. Biol.
Copyright © 2005 American Thoracic Society