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Published ahead of print on January 18, 2005, doi:10.1164/rccm.200409-1205WS

Am. J. Respir. Crit. Care Med., Volume 171, Number 7, April 2005, 792-798

A more recent version of this article appeared on April 1, 2005
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Submitted on September 17, 2004
Accepted on December 28, 2004

Needs and Opportunities for Research in Hypersensitivity Pneumonitis

Jordan N Fink1, Hector G Ortega1, Herbert Y Reynolds1*, Yvon F Cormier1, Leland L Fan1, Teri J Franks1, Kathleen Kreiss1, Steven Kunkel1, David Lynch1, Santiago Quirce1, Cecile Rose1, Robert Schleimer1, Mark R Schuyler1, Moises Selman1, Douglas Trout1, and Yasuyuki Yoshizawa1

1 National Heart, Lung, and Blood Institute and the Office of Rare Diseases, Department of Health and Human Services, National Institutes of Health, Bethesda, MD, USA

* To whom correspondence should be addressed. E-mail: reynoldh{at}nhlbi.nih.gov.

Hypersensitivity Pneumonitis (HP) develops after inhalation of many different environmental antigens, causing variable clinical symptoms that often make diagnosis uncertain. The prevalence of HP is higher than recognized, especially its chronic form. Mechanisms of disease are still incompletely known. Strategies to improve detection and diagnosis are needed and treatment options, principally avoidance, are limited. A workshop recommended: a population based study to more accurately document the incidence and prevalence of HP; better classification of disease stages, including natural history; evaluation of diagnostic tests and biomarkers used to detect disease; better correlation of computerized tomography lung imaging and pathological changes; more study of inflammatory and immune mechanisms; and improvement of animal models that are more relevant for human disease.
Key words: Hypersensitivity Pneumonitis, Extrinsic Allergic Alveolitis, Inhilation Challenge, Occupational Exposure, Granulomatous Interstitial Lung Disease




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