Published ahead of print on December 10, 2004, doi:10.1164/rccm.200408-1088OC
Am. J. Respir. Crit. Care Med., Volume 171, Number 6, March 2005, 587-590
A more recent version of this article appeared on March 15, 2005
Submitted on August 24, 2004
Accepted on December 1, 2004
Fluticasone Improves Pulmonary Function in Children Under 2 Years old With Risk Factors for Asthma
Alejandro M Teper1*, Carlos D Kofman1, Gabriela A Szulman1, Santiago M Vidaurreta1, and Alberto F Maffey1
1 Respiratory Center, Hospital de Ninos Ricardo Gutierrez, Buenos Aires, Argentina
* To whom correspondence should be addressed. E-mail: ateper{at}intramed.net.
This study assessed the effects of treatment with fluticasone in children under 2 years old with recurrent wheezing and risk factors of developing asthma. This double-blind placebo-controlled study randomized children to receive fluticasone (125 mcg) (n=14) or placebo (n=12) twice daily for 6 months. Pulmonary function was assessed at the beginning and end, and parents filled out a daily diary recording respiratory symptoms, need for rescue medication, and emergency care. The standard deviation score of maximum flow at functional residual capacity was
-0.74 ± 0.6 at the beginning and 0.44 ± 1 at the end for the fluticasone group (p= 0.001) and -0.79 ± 0.3 at the beginning and -0.78 ± 1.4 at the end for the placebo group (p= 0.97). A statistically significant difference (p= 0.02) was observed between treatments. Percentage of symptom-free days was 91.3 ± 7 for fluticasone and 83.9 ± 10 for placebo (p=0.05), number of respiratory exacerbations was 2.1 ± 1.7 and 4.1 ± 3 (p= 0.04), and percentage of days on albuterol was 8.6 ± 6 and 16.3 ± 9 (p= 0.028). Treatment with fluticasone twice daily for 6 months improves pulmonary function and clinical outcomes in asthmatic children under 2 years old.
Key words: Asthma, infants, inhaled corticosteroids, pulmonary function
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