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Published ahead of print on December 3, 2004, doi:10.1164/rccm.200408-1010OC

Am. J. Respir. Crit. Care Med., Volume 171, Number 5, March 2005, 426-430

A more recent version of this article appeared on March 1, 2005
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Submitted on August 17, 2004
Accepted on November 26, 2004

Induced Sputum 8-Isoprostane Concentrations in Inflammatory Airway Diseases

Lisa G Wood1, Manohar L Garg2, Jodie L Simpson1, Trevor A Mori3, Kevin D Croft3, Peter AB Wark1, and Peter G Gibson1*

1 Department of Respiratory and Sleep Medicine, Hunter Medical Research Institute, John Hunter Hospital, Newcastle, NSW, Australia, 2 Discipline Nutrition and Dietetics, School of Health Sciences, Faculty of Health, University of Newcastle, Newcastle, NSW, Australia, 3 School of Medicine and Pharmacology, University of Western Australia, Perth, WA, Australia

* To whom correspondence should be addressed. E-mail: Peter.Gibson{at}hunter.health.nsw.gov.au.

Induced sputum 8-iso-PGF2{alpha} concentrations may be a useful marker of oxidative stress in airways disease. This study aimed to examine oxidative stress (measured by 8-iso-PGF2{alpha}) in airways disease, according to disease type (asthma and bronchiectasis), disease activity (stable and acute asthma) and disease pattern (intermittent, mild, moderate and severe persistent asthma). We compared subjects with stable asthma (n=71) and bronchiectasis (n=23) to healthy controls (n=29). Another group of asthmatics (n=39) were assessed during and post acute exacerbation. Induced sputum 8-iso-PGF2{alpha} concentrations were validated and found to be elevated in stable asthma and bronchiectasis versus controls (median (interquartile range); 216 (103-389) and 698 (264-1613) versus 123 (41-290) ng/L, p<0.001) and increased as clinical asthma pattern worsened (intermittent 115 (42-153), mild persistent 116 (89-229) ng/L, moderate persistent 183 (110-317) ng/L, severe persistent 387 (102-587) ng/L, p=0.010). Sputum 8-iso-PGF2{alpha} concentrations were elevated during acute asthma and decreased with recovery (458 (227-950) ng/L versus 214 (148-304) ng/L, p=0.0002). We conclude 8-iso-PGF2{alpha} is involved in the pathophysiology of inflammatory airway diseases, being related to disease type, pattern and activity. Analysis of 8-iso-PGF2{alpha} concentrations in induced sputum provides a useful tool for monitoring oxidative stress and investigating strategies aimed at reducing oxidative stress in airways disease.
Key words: isoprostanes, oxidative stress, lipid peroxidation




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