help button home button
AJRCCM
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH
Published ahead of print on August 11, 2005, doi:10.1164/rccm.200407-989OC

Am. J. Respir. Crit. Care Med., Volume 172, Number 9, November 2005, 1128-1132

A more recent version of this article appeared on November 1, 2005
This Article
Right arrow Full Text (PDF)
Right arrow All Versions of this Article:
200407-989OCv1
172/9/1128    most recent
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Brody, A. S
Right arrow Articles by Quan, J.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Brody, A. S
Right arrow Articles by Quan, J.

Submitted on July 30, 2004
Accepted on August 9, 2005

Computed Tomography Correlates with Pulmonary Exacerbations in Children with Cystic Fibrosis

Alan S Brody1*, Heidi Sucharew2, Jonathan D Campbell2, Steven P Millard2, Paul L Molina3, Jeffrey S Klein4, and Joanne Quan5

1 Department Radiology and Pediatrics, Cincinnati Children's Hospital and Medical Center, Cincinnati, OH, USA, 2 Statistical Analysis Unit, Cystic Fibrosis Foundation Therapeutics Development Network Coordinating Center, Seattle, WA, USA, 3 Department of Radiology, University of North Carolina School of Medicine, Chapel Hill, NC, USA, 4 Department of Radiology, University of Vermont, Fletcher Allen Health Care, Burlington, VT, USA, 5 Medical Affairs, Genentech, Inc., South San Francisco, CA, USA

* To whom correspondence should be addressed. E-mail: alan.brody{at}cchmc.org.

Rationale: High-resolution computed tomography has been suggested as a potential outcome surrogate for CF lung disease. An important attribute of a valid outcome surrogate is that the surrogate reflects true clinical outcomes. Objectives: We performed this study to validate high-resolution computed tomography, a proposed surrogate outcome measure for CF lung disease, against a true clinical outcome, the number of respiratory tract exacerbations occurring in two years; and to assess the correlation of CT scores and PFTs with this clinical outcome. Methods: CTs and PFTs were performed on 6 to 10 year old children at the beginning and end of a two-year study during which the number of exacerbations were recorded. Spearman correlations and Poissin models were used to assess the correlation of the number of exacerbations with baseline values and changes in PFTs and CT scores. Measurements and Main Results: Nine of 61 subjects had a total of 22 respiratory tract exacerbations. At baseline, PFTs and four CT scores showed significant correlation with number of exacerbations, but no variable by itself predicted exacerbations with high accuracy. For change over the two-year period, three CT scores showed significant correlation with exacerbations, while no PFTs showed significant correlation. Conclusion: This is the first study showing correlation between CT and a true clinical outcome. Change in CT scores correlates moderately well with the number of exacerbation. Poor correlation between change in FEV1 and exacerbations suggests that HRCT may be a more appropriate outcome surrogate for longitudinal studies of young children.
Key words: computerized tomography X-ray, surrogate endpoint, pulmonary function tests, children, forced expiratory volume




This article has been cited by other articles:


Home page
 ChestHome page
M. Klein, M. Cohen-Cymberknoh, S. Armoni, D. Shoseyov, R. Chisin, M. Orevi, N. Freedman, and E. Kerem
18F-Fluorodeoxyglucose-PET/CT Imaging of Lungs in Patients With Cystic Fibrosis
Chest, November 1, 2009; 136(5): 1220 - 1228.
[Abstract] [Full Text] [PDF]

Home page
 RadiologyHome page
M. T. Saavedra and D. A. Lynch
Emerging Roles for CT Imaging in Cystic Fibrosis
Radiology, August 1, 2009; 252(2): 327 - 329.
[Full Text] [PDF]

Home page
 RadiologyHome page
P. M. Farrell, J. Collins, L. S. Broderick, M. J. Rock, Z. Li, M. R. Kosorok, A. Laxova, W. M. Gershan, and A. S. Brody
Association between Mucoid Pseudomonas Infection and Bronchiectasis in Children with Cystic Fibrosis
Radiology, August 1, 2009; 252(2): 534 - 543.
[Abstract] [Full Text] [PDF]

Home page
 ChestHome page
F. Santamaria, S. Montella, H. A. W. M. Tiddens, G. Guidi, V. Casotti, M. Maglione, and P. A. de Jong
Structural and Functional Lung Disease in Primary Ciliary Dyskinesia
Chest, August 1, 2008; 134(2): 351 - 357.
[Abstract] [Full Text] [PDF]

Home page
 ThoraxHome page
P M Gustafsson, P A De Jong, H A W M Tiddens, and A Lindblad
Multiple-breath inert gas washout and spirometry versus structural lung disease in cystic fibrosis
Thorax, February 1, 2008; 63(2): 129 - 134.
[Abstract] [Full Text] [PDF]

Home page
 Proc Am Thorac SocHome page
T. E. Robinson
Computed Tomography Scanning Techniques for the Evaluation of Cystic Fibrosis Lung Disease
Proceedings of the ATS, August 1, 2007; 4(4): 310 - 315.
[Abstract] [Full Text] [PDF]

Home page
 Proc Am Thorac SocHome page
M. B. Dolovich and D. P. Schuster
Positron Emission Tomography and Computed Tomography versus Positron Emission Tomography Computed Tomography: Tools for Imaging the Lung
Proceedings of the ATS, August 1, 2007; 4(4): 328 - 333.
[Abstract] [Full Text] [PDF]

Home page
 Proc Am Thorac SocHome page
P. A. de Jong and H. A. W. M. Tiddens
Cystic Fibrosis Specific Computed Tomography Scoring
Proceedings of the ATS, August 1, 2007; 4(4): 338 - 342.
[Abstract] [Full Text] [PDF]

Home page
 Proc Am Thorac SocHome page
H. A. W. M. Tiddens and P. A. de Jong
Imaging and Clinical Trials in Cystic Fibrosis
Proceedings of the ATS, August 1, 2007; 4(4): 343 - 346.
[Abstract] [Full Text] [PDF]

Home page
 Proc Am Thorac SocHome page
A. S. Brody
Computed Tomography Scanning in Cystic Fibrosis Research Trials: Practical Lessons from Three Clinical Trials in the United States
Proceedings of the ATS, August 1, 2007; 4(4): 350 - 354.
[Abstract] [Full Text] [PDF]

Home page
 Proc Am Thorac SocHome page
Z. A. Aziz
United Kingdom Cystic Fibrosis Gene Therapy Consortium Multidose Trial: The Proposed Use of Computed Tomography
Proceedings of the ATS, August 1, 2007; 4(4): 355 - 358.
[Abstract] [Full Text] [PDF]

Home page
 Proc Am Thorac SocHome page
B. W. Ramsey
Use of Lung Imaging Studies as Outcome Measures for Development of New Therapies in Cystic Fibrosis
Proceedings of the ATS, August 1, 2007; 4(4): 359 - 363.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
D. P. Schuster
The Opportunities and Challenges of Developing Imaging Biomarkers to Study Lung Function and Disease
Am. J. Respir. Crit. Care Med., August 1, 2007; 176(3): 224 - 230.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
S. D. Davis, L. A. Fordham, A. S. Brody, T. L. Noah, G. Z. Retsch-Bogart, B. F. Qaqish, B. C. Yankaskas, R. C. Johnson, and M. W. Leigh
Computed Tomography Reflects Lower Airway Inflammation and Tracks Changes in Early Cystic Fibrosis
Am. J. Respir. Crit. Care Med., May 1, 2007; 175(9): 943 - 950.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Roentgenol.Home page
M. P. Kennedy, P. G. Noone, M. W. Leigh, M. A. Zariwala, S. L. Minnix, M. R. Knowles, and P. L. Molina
High-Resolution CT of Patients with Primary Ciliary Dyskinesia
Am. J. Roentgenol., May 1, 2007; 188(5): 1232 - 1238.
[Abstract] [Full Text] [PDF]

Home page
 ThoraxHome page
C. H Goss and J. L Burns
Exacerbations in cystic fibrosis {middle dot} 1: Epidemiology and pathogenesis
Thorax, April 1, 2007; 62(4): 360 - 367.
[Abstract] [Full Text] [PDF]

Home page
 ThoraxHome page
Z A Aziz, J C Davies, E W Alton, A U Wells, D M Geddes, and D M Hansell
Computed tomography and cystic fibrosis: promises and problems
Thorax, February 1, 2007; 62(2): 181 - 186.
[Abstract] [Full Text] [PDF]

Home page
 ChestHome page
E. P. Judge, J. D. Dodd, J. B. Masterson, and C. G. Gallagher
Pulmonary Abnormalities on High-Resolution CT Demonstrate More Rapid Decline Than FEV1 in Adults With Cystic Fibrosis.
Chest, November 1, 2006; 130(5): 1424 - 1432.
[Abstract] [Full Text] [PDF]

Home page
 ChestHome page
F. Santamaria, S. Montella, L. Camera, C. Palumbo, L. Greco, and A. L. Boner
Lung structure abnormalities, but normal lung function in pediatric bronchiectasis.
Chest, August 1, 2006; 130(2): 480 - 486.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
F. J. Accurso
Update in cystic fibrosis 2005.
Am. J. Respir. Crit. Care Med., May 1, 2006; 173(9): 944 - 947.
[Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH
Proc. Am. Thorac. Soc. Am. J. Respir. Cell Mol. Biol.
Copyright © 2005 American Thoracic Society 		  New Orleans Int'l Conf