help button home button
AJRCCM
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH
Published ahead of print on September 3, 2004, doi:10.1164/rccm.200407-929OC

Am. J. Respir. Crit. Care Med., Volume 170, Number 10, November 2004, 1095-1100

A more recent version of this article appeared on November 15, 2004
This Article
Right arrow Full Text (PDF)
Right arrow All Versions of this Article:
200407-929OCv1
170/10/1095    most recent
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Urschitz, M. S
Right arrow Articles by Poets, C. F
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Urschitz, M. S
Right arrow Articles by Poets, C. F

Submitted on July 18, 2004
Accepted on September 2, 2004

Automatic Control of the Inspired Oxygen Fraction in Preterm Infants. A Randomized Cross-over Trial

Michael S Urschitz1, Werner Horn2, Andreas Seyfang3, Antonella Hallenberger1, Tina Herberts4, Silvia Miksch3, Christian Popow5, Ingo Mueller-Hansen1, and Christian F Poets1*

1 Department of Neonatology, Tuebingen University Hospital, Tuebingen, Germany, 2 Department of Medical Cybernetics and Artificial Intelligence, Medical University Vienna, Vienna, Austria, 3 Institute of Software Technology and Interactive Systems, Vienna University of Technology, Vienna, Austria, 4 Department of Medical Biometry, Tuebingen University Hospital, Tuebingen, Germany, 5 Department of Pediatrics and Adolescent Medicine, Medical University Vienna, Vienna, Austria

* To whom correspondence should be addressed. E-mail: cfpoets{at}med.uni-tuebingen.de.

In preterm infants receiving supplemental oxygen, manual control of the inspired oxygen fraction is often time-consuming and inappropriate. We developed a system for automatic oxygen control and hypothesized that this system is more effective than routine manual oxygen control in maintaining target arterial oxygen saturation levels. We performed a randomized controlled cross-over clinical trial in 12 preterm infants receiving nasal continuous positive airway pressure and supplemental oxygen. Periods with automatic and routine manual oxygen control were compared to periods of optimal control by a fully dedicated person. The median (range) percentage of time with arterial oxygen saturation levels within target range (87-96%) was 81.7% (39.0-99.8) for routine manual oxygen control, 91.0% (41.4-99.3) for optimal control, and 90.5% (59.0-99.4) for automatic control (ANOVA: p=0.01). Pair-wise post-hoc comparisons revealed a statistically significant difference between automatic and routine manual oxygen control (Dunnett's test: p=0.02). The frequency of manual oxygen adjustments was lowest in automatic control (Friedman's test: p<0.001). Automatic oxygen control may optimize oxygen administration to preterm infants receiving nasal continuous positive airway pressure and reduce nursing time spent with oxygen control.
Key words: closed-loop oxygen control, continuous positive airway pressure, mechanical ventilation, neonatal lung disease, infants




This article has been cited by other articles:


Home page
 PediatricsHome page
T.-H. Nghiem, J. I. Hagadorn, N. Terrin, S. Syke, B. MacKinnon, and C. H. Cole
Nurse Opinions and Pulse Oximeter Saturation Target Limits for Preterm Infants
Pediatrics, May 1, 2008; 121(5): e1039 - e1046.
[Abstract] [Full Text] [PDF]

Home page
 Anesth. Analg.Home page
N. Claure
Automated Regulation of Inspired Oxygen in Preterm Infants: Oxygenation Stability and Clinician Workload
Anesth. Analg., December 1, 2007; 105(6S_Suppl): S37 - S41.
[Abstract] [Full Text] [PDF]

Home page
 PediatricsHome page
J. I. Hagadorn, A. M. Furey, T.-H. Nghiem, C. H. Schmid, D. L. Phelps, D.-A. M. Pillers, C. H. Cole, and and the AVIOx Study Group
Achieved Versus Intended Pulse Oximeter Saturation in Infants Born Less Than 28 Weeks' Gestation: The AVIOx Study
Pediatrics, October 1, 2006; 118(4): 1574 - 1582.
[Abstract] [Full Text] [PDF]

Home page
 PediatricsHome page
J. S. Greenspan and J. P. Goldsmith
Oxygen Therapy in Preterm Infants: Hitting the Target
Pediatrics, October 1, 2006; 118(4): 1740 - 1741.
[Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
A. Bush, F. Accurso, W. MacNee, S. C. Lazarus, and E. Abraham
Cystic Fibrosis, Pediatrics, Control of Breathing, Pulmonary Physiology and Anatomy, and Surfactant Biology in AJRCCM in 2004
Am. J. Respir. Crit. Care Med., March 15, 2005; 171(6): 545 - 553.
[Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH
Proc. Am. Thorac. Soc. Am. J. Respir. Cell Mol. Biol.
Copyright © 2004 American Thoracic Society 		  CCM abstracts