help button home button
AJRCCM
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH
Published ahead of print on November 19, 2004, doi:10.1164/rccm.200407-928OC

Am. J. Respir. Crit. Care Med., Volume 171, Number 3, February 2005, 282-286

A more recent version of this article appeared on February 1, 2005
This Article
Right arrow Full Text (PDF)
Right arrow All Versions of this Article:
200407-928OCv1
171/3/282    most recent
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Kaditis, A. G
Right arrow Articles by Gourgoulianis, K.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Kaditis, A. G
Right arrow Articles by Gourgoulianis, K.

Submitted on July 20, 2004
Accepted on November 15, 2004

Morning Levels of C-Reactive Protein in Children with Obstructive Sleep-disordered Breathing

Athanasios G Kaditis1*, Emmanouel I Alexopoulos1, Efthimia Kalampouka1, Eleni Kostadima2, Anastasios Germenis3, Elias Zintzaras4, and Konstantinos Gourgoulianis2

1 Department of Pediatrics (Pediatric Pulmonary Unit), University of Thessaly School of Medicine and Larissa University Hospital, Larissa, Greece; Sleep Disorders Laboratory, University of Thessaly School of Medicine and Larissa University Hospital, Larissa, Greece, 2 Sleep Disorders Laboratory, University of Thessaly School of Medicine and Larissa University Hospital, Larissa, Greece, 3 Department of Immunology, University of Thessaly School of Medicine and Larissa University Hospital, Larissa, Greece, 4 Department of Biomathematics, University of Thessaly School of Medicine and Larissa University Hospital, Larissa, Greece

* To whom correspondence should be addressed. E-mail: KADITIA{at}hotmail.com.

Obstructive sleep-disordered breathing is associated with cardiovascular disease in adults and elevated C-reactive protein has been proposed as a link between the two disorders. We hypothesized that children with sleep-disordered breathing have higher C-reactive protein values than controls. C-reactive protein was measured in 39 children (mean age ± standard deviation: 6.9 ± 3.2 years) without snoring (controls) and in 102 children (6.2 ± 2.2) with habitual snoring who underwent polysomnography. No significant differences were found in mean C-reactive protein values between controls (0.12 ± 0.16 mg/dL) (n = 39) and: snorers with apnea-hypopnea index < 1 episode/hour (0.15 ± 0.26) (n = 18), snorers with index ≥ 1 and < 5 (0.15 ± 0.26) (n = 54), and snorers with index ≥ 5 (0.22 ± 0.43) (n = 30) (p > 0.05). There was no correlation between C-reactive protein or log-transformed C-reactive protein values and: apnea-hypopnea index, respiratory movement/arousal index, oxygen saturation of hemoglobin nadir, oxygen desaturation (≥ 4%) of hemoglobin index, or % sleep time with saturation less than 95% (p > 0.05). Thus, findings of higher C-reactive protein values in adults with sleep-disordered breathing and correlations of these values with polysomnography indices were not confirmed in children.
Key words: atherosclerosis, obstructive sleep apnea, snoring




This article has been cited by other articles:


Home page
 J. Appl. Physiol.Home page
R. Arens and H. Muzumdar
Childhood obesity and obstructive sleep apnea syndrome
J Appl Physiol, February 1, 2010; 108(2): 436 - 444.
[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Endocrinol. Metab.Home page
M. Tsaoussoglou, E. O. Bixler, S. Calhoun, G. P. Chrousos, K. Sauder, and A. N. Vgontzas
Sleep-Disordered Breathing in Obese Children Is Associated with Prevalent Excessive Daytime Sleepiness, Inflammation, and Metabolic Abnormalities
J. Clin. Endocrinol. Metab., January 1, 2010; 95(1): 143 - 150.
[Abstract] [Full Text] [PDF]

Home page
 Eur Respir JHome page
F. Roche, J-M. Gaspoz, V. Pichot, M. Picard-Kossovsky, D. Maudoux, A. Garcin, S. Celle, E. Sforza, J. C. Barthelemy, and on behalf of the PROOF and SYNAPSE Study Groups
Association between C-reactive protein and unrecognised sleep-disordered breathing in the elderly
Eur. Respir. J., April 1, 2009; 33(4): 797 - 803.
[Abstract] [Full Text] [PDF]

Home page
 ChestHome page
M. M.-s. Lui, J. C.-m. Lam, H. K.-F. Mak, A. Xu, C. Ooi, D. C.-l. Lam, J. C.-w. Mak, P. L. Khong, and M. S.-M. Ip
C-Reactive Protein Is Associated With Obstructive Sleep Apnea Independent of Visceral Obesity
Chest, April 1, 2009; 135(4): 950 - 956.
[Abstract] [Full Text] [PDF]

Home page
 CirculationHome page
V. K. Somers, D. P. White, R. Amin, W. T. Abraham, F. Costa, A. Culebras, S. Daniels, J. S. Floras, C. E. Hunt, L. J. Olson, et al.
Sleep Apnea and Cardiovascular Disease: An American Heart Association/American College of Cardiology Foundation Scientific Statement From the American Heart Association Council for High Blood Pressure Research Professional Education Committee, Council on Clinical Cardiology, Stroke Council, and Council on Cardiovascular Nursing In Collaboration With the National Heart, Lung, and Blood Institute National Center on Sleep Disorders Research (National Institutes of Health)
Circulation, September 2, 2008; 118(10): 1080 - 1111.
[Full Text] [PDF]

Home page
 J Am Coll CardiolHome page
V. K. Somers, D. P. White, R. Amin, W. T. Abraham, F. Costa, A. Culebras, S. Daniels, J. S. Floras, C. E. Hunt, L. J. Olson, et al.
Sleep Apnea and Cardiovascular Disease: An American Heart Association/American College of Cardiology Foundation Scientific Statement From the American Heart Association Council for High Blood Pressure Research Professional Education Committee, Council on Clinical Cardiology, Stroke Council, and Council on Cardiovascular Nursing In Collaboration With the National Heart, Lung, and Blood Institute National Center on Sleep Disorders Research (National Institutes of Health)
J. Am. Coll. Cardiol., August 19, 2008; 52(8): 686 - 717.
[Full Text] [PDF]

Home page
 ChestHome page
A. G. Kaditis, M. G. Ioannou, K. Chaidas, E. I. Alexopoulos, M. Apostolidou, T. Apostolidis, G. Koukoulis, and K. Gourgoulianis
Cysteinyl Leukotriene Receptors Are Expressed by Tonsillar T Cells of Children With Obstructive Sleep Apnea
Chest, August 1, 2008; 134(2): 324 - 331.
[Abstract] [Full Text] [PDF]

Home page
 ChestHome page
F. Lopez-Jimenez, F. H. Sert Kuniyoshi, A. Gami, and V. K. Somers
Obstructive Sleep Apnea: Implications for Cardiac and Vascular Disease
Chest, March 1, 2008; 133(3): 793 - 804.
[Full Text] [PDF]

Home page
 Proc Am Thorac SocHome page
O. S. Capdevila, L. Kheirandish-Gozal, E. Dayyat, and D. Gozal
Pediatric Obstructive Sleep Apnea: Complications, Management, and Long-term Outcomes
Proceedings of the ATS, February 15, 2008; 5(2): 274 - 282.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
D. Gozal and L. Kheirandish-Gozal
Cardiovascular Morbidity in Obstructive Sleep Apnea: Oxidative Stress, Inflammation, and Much More
Am. J. Respir. Crit. Care Med., February 15, 2008; 177(4): 369 - 375.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
G. Parati, C. Lombardi, and K. Narkiewicz
Sleep apnea: epidemiology, pathophysiology, and relation to cardiovascular risk
Am J Physiol Regulatory Integrative Comp Physiol, October 1, 2007; 293(4): R1671 - R1683.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
D. Gozal, V. M. Crabtree, O. Sans Capdevila, L. A. Witcher, and L. Kheirandish-Gozal
C-reactive Protein, Obstructive Sleep Apnea, and Cognitive Dysfunction in School-aged Children
Am. J. Respir. Crit. Care Med., July 15, 2007; 176(2): 188 - 193.
[Abstract] [Full Text] [PDF]

Home page
 Arch Pediatr Adolesc MedHome page
E. Zintzaras and A. G. Kaditis
Sleep-Disordered Breathing and Blood Pressure in Children: A Meta-analysis
Arch Pediatr Adolesc Med, February 1, 2007; 161(2): 172 - 178.
[Abstract] [Full Text] [PDF]

Home page
 Eur Respir JHome page
W. T. McNicholas, M. R. Bonsignore, and the Management Committee of EU COST ACTION B26
Sleep apnoea as an independent risk factor for cardiovascular disease: current evidence, basic mechanisms and research priorities
Eur. Respir. J., January 1, 2007; 29(1): 156 - 178.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
T. Sato, M. Takeno, K. Honma, H. Yamauchi, Y. Saito, T. Sasaki, H. Morikubo, Y. Nagashima, S. Takagi, K. Yamanaka, et al.
Heme Oxygenase-1, a Potential Biomarker of Chronic Silicosis, Attenuates Silica-induced Lung Injury
Am. J. Respir. Crit. Care Med., October 15, 2006; 174(8): 906 - 914.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
R. L. Horner and T. D. Bradley
Update in sleep and control of ventilation 2005.
Am. J. Respir. Crit. Care Med., April 15, 2006; 173(8): 827 - 832.
[Full Text] [PDF]

Home page
 ChestHome page
L. M. O'Brien, L. D. Serpero, R. Tauman, and D. Gozal
Plasma adhesion molecules in children with sleep-disordered breathing.
Chest, April 1, 2006; 129(4): 947 - 953.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
A. D. Goldbart, J. L. Goldman, M. C. Veling, and D. Gozal
Leukotriene Modifier Therapy for Mild Sleep-disordered Breathing in Children
Am. J. Respir. Crit. Care Med., August 1, 2005; 172(3): 364 - 370.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
A. Kelly and C. L. Marcus
Childhood Obesity, Inflammation, and Apnea: What Is the Future for Our Children?
Am. J. Respir. Crit. Care Med., February 1, 2005; 171(3): 202 - 203.
[Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH
Proc. Am. Thorac. Soc. Am. J. Respir. Cell Mol. Biol.
Copyright © 2004 American Thoracic Society 		  2nd Annual Dinner