help button home button
AJRCCM
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH
Published ahead of print on March 11, 2005, doi:10.1164/rccm.200407-914OC

Am. J. Respir. Crit. Care Med., Volume 171, Number 11, June 2005, 1246-1251

A more recent version of this article appeared on June 1, 2005
This Article
Right arrow Full Text (PDF)
Right arrow All Versions of this Article:
200407-914OCv1
171/11/1246    most recent
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Yasuda, H.
Right arrow Articles by Sasaki, H.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Yasuda, H.
Right arrow Articles by Sasaki, H.

Submitted on July 15, 2004
Accepted on March 4, 2005

Increased Arterial Carboxyhemoglobin Concentrations in Chronic Obstructive Pulmonary Disease

Hiroyasu Yasuda1*, Mutsuo Yamaya1, Katsutoshi Nakayama1, Satoru Ebihara1, Takahiko Sasaki1, Shoji Okinaga1, Daisuke Inoue1, Masanori Asada1, Miyako Nemoto1, and Hidetada Sasaki1

1 Department of Geriatric and Respiratory Medicine, Tohoku University School of Medicine, Sendai, Japan

* To whom correspondence should be addressed. E-mail: yasuda{at}geriat.med.tohoku.ac.jp.

Rationale; Exhaled carbon monoxide (CO) and arterial blood carboxyhemoglobin concentrations (Hb-CO) increase in inflammatory pulmonary diseases. Objectives; To study whether arterial Hb-CO is useful to monitor disease activity in patients with chronic obstructive pulmonary disease (COPD) who had stopped smoking. Methods; We measured arterial Hb-CO, arteriovenous (a-v) Hb-CO differences, and forced expiratory volume in one second (FEV1) in 58 patients with COPD and 61 ex-smoking control subjects. Results; Arterial Hb-CO in patients at stable conditions were higher than those in control subjects (p< 0.0001). Furthermore, the Hb-CO in patients at the exacerbations (p< 0.0001) were higher than those at the stable conditions. Arterial Hb-CO in patients at stage III were higher than those in patients at stage II, and the Hb-CO in patients at stage IV were higher than those in patients at stage III at the stable conditions and exacerbations. Arterial Hb-CO correlated with exhaled CO in COPD patients at stage II and stage III at the exacerbations. Arterial Hb-CO inversely correlated with the arterial blood partial oxygen pressure and FEV1. A-v Hb-CO differences in patients at the exacerbations did not differ from those in patients at stable conditions and from those in control subjects. Moreover, arterial Hb-CO correlated with serum C-reactive protein values and serum lipid peroxide concentrations. Conclusions; These findings suggest that increased arterial Hb-CO may relate to severity in patients with COPD due to lung and systemic inflammation and production of reactive oxygen species.
Key words: carboxyhemoglobin; heme oxygenase; carbon monoxide; systemic inflammation; chronic obstructive pulmonary disease




This article has been cited by other articles:


Home page
 ChestHome page
R. L. Owens, S. Yim-Yeh, and A. Malhotra
Carbon Monoxide Poisoning, or Carbon Monoxide Protection?
Chest, November 1, 2008; 134(5): 895 - 896.
[Full Text] [PDF]

Home page
 ChestHome page
M. Kobayashi, N. Miyazawa, M. Takeno, S. Murakami, Y. Kirino, A. Okouchi, T. Kaneko, and Y. Ishigatsubo
Circulating Carbon Monoxide Level Is Elevated After Sleep in Patients With Obstructive Sleep Apnea
Chest, November 1, 2008; 134(5): 904 - 910.
[Abstract] [Full Text] [PDF]

Home page
 Eur Respir JHome page
G. P. Anderson
The COPD CO-factor
Eur. Respir. J., December 1, 2007; 30(6): 1032 - 1034.
[Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
T. Sato, M. Takeno, K. Honma, H. Yamauchi, Y. Saito, T. Sasaki, H. Morikubo, Y. Nagashima, S. Takagi, K. Yamanaka, et al.
Heme Oxygenase-1, a Potential Biomarker of Chronic Silicosis, Attenuates Silica-induced Lung Injury
Am. J. Respir. Crit. Care Med., October 15, 2006; 174(8): 906 - 914.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
L. M. Fabbri, F. Luppi, B. Beghe, and K. F. Rabe
Update in chronic obstructive pulmonary disease 2005.
Am. J. Respir. Crit. Care Med., May 15, 2006; 173(10): 1056 - 1065.
[Full Text] [PDF]

Home page
 ChestHome page
M. Westphal, T. P. Weber, H. Yasuda, M. Yamaya, K. Nakayama, T. Sasaki, S. Ebihara, T. Ebihara, and H. Sasaki
Is the Arteriovenous Carboxyhemoglobin Gradient Really a Useful Marker in Systemic Inflammation?
Chest, November 1, 2005; 128(5): 3771 - 3772.
[Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
S. Permutt and D. B. Pearse
Blood Carbon Monoxide Will Increase from a Decline in Pulmonary Function Alone
Am. J. Respir. Crit. Care Med., November 1, 2005; 172(9): 1231 - 1231.
[Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH
Proc. Am. Thorac. Soc. Am. J. Respir. Cell Mol. Biol.
Copyright © 2005 American Thoracic Society 		  ATS Sleep Tracings Quiz