help button home button
AJRCCM
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH
Published ahead of print on December 10, 2004, doi:10.1164/rccm.200407-867OC

Am. J. Respir. Crit. Care Med., Volume 171, Number 6, March 2005, 591-597

A more recent version of this article appeared on March 15, 2005
This Article
Right arrow Full Text (PDF)
Right arrow All Versions of this Article:
200407-867OCv1
171/6/591    most recent
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Casanova, C.
Right arrow Articles by Celli, B. R
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Casanova, C.
Right arrow Articles by Celli, B. R

Submitted on July 12, 2004
Accepted on December 6, 2004

The Inspiratory to Total Lung Capacity Ratio Predicts Mortality in Patients with COPD

Ciro Casanova1*, Claudia Cote2, Juan P de Torres1, Armando Aguirre-Jaime1, Jose M Marin3, Victor Pinto-Plata4, and Bartolome R Celli4

1 Respiratory Research Institute, Hospital Universitario N.S. de Candelaria, Santa Cruz de Tenerife, Spain, 2 Pulmonary Department, Bay Pines VA Medical Center, St. Petersburg, FL, USA, 3 Pulmonary Department, Hospital Miguel Servet, Zaragoza, Spain, 4 Pulmonary and Critical Care Department, Caritas - St Elizabeth's Medical Center, Boston, MA, USA

* To whom correspondence should be addressed. E-mail: ccasanova{at}canarias.org.

Static lung hyperinflation (LH) has important clinical consequences in patients with chronic obstructive pulmonary disease (COPD). We analysed the power of LH as measured by the inspiratory capacity to total lung capacity ratio (IC/TLC) to predict mortality in a cohort of 689 patients with COPD (95% males; FEV1 1.17 L) with a mean follow up of 34 months. We also compared the predictive value of IC/TLC with that of BODE. Subjects who died (183; 27%) were older , had lower body mass index (BMI), less FEV1, lower IC/TLC ratio, walked less in the six minute walking distance (6MWD), had more dyspnea, BODE index and co-morbidity (p<0.001). Using logistic regression analysis IC/TLC was a good and independent predictor of all-cause and respiratory mortality. Using ROC type II curves, IC/TLC compared favourably to the FEV1 and predicted mortality independently of BODE . We conclude that IC/TLC is an independent risk factor for mortality in subjects with COPD. We propose that this ratio be considered in the assessment of patients with COPD.
Key words: COPD; inspiratory capacity; outcomes.




This article has been cited by other articles:


Home page
 Am. J. Respir. Crit. Care Med.Home page
J. Ora, P. Laveneziana, D. Ofir, A. Deesomchok, K. A. Webb, and D. E. O'Donnell
Combined Effects of Obesity and Chronic Obstructive Pulmonary Disease on Dyspnea and Exercise Tolerance
Am. J. Respir. Crit. Care Med., November 15, 2009; 180(10): 964 - 971.
[Abstract] [Full Text] [PDF]

Home page
 ThoraxHome page
R Yuan, J C Hogg, P D Pare, D D Sin, J C Wong, Y Nakano, A M McWilliams, S Lam, and H O Coxson
Prediction of the rate of decline in FEV1 in smokers using quantitative computed tomography
Thorax, November 1, 2009; 64(11): 944 - 949.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
R. Rodriguez-Roisin, M. Drakulovic, D. A. Rodriguez, J. Roca, J. A. Barbera, and P. D. Wagner
Ventilation-perfusion imbalance and chronic obstructive pulmonary disease staging severity
J Appl Physiol, June 1, 2009; 106(6): 1902 - 1908.
[Abstract] [Full Text] [PDF]

Home page
 Eur Respir JHome page
J. P. de Torres, C. G. Cote, M. V. Lopez, C. Casanova, O. Diaz, J. M. Marin, V. Pinto-Plata, M. M. de Oca, H. Nekach, L. J. Dordelly, et al.
Sex differences in mortality in patients with COPD
Eur. Respir. J., March 1, 2009; 33(3): 528 - 535.
[Abstract] [Full Text] [PDF]

Home page
 Eur Respir JHome page
C. Vassaux, L. Torre-Bouscoulet, S. Zeineldine, F. Cortopassi, H. Paz-Diaz, B. R. Celli, and V. M. Pinto-Plata
Effects of hyperinflation on the oxygen pulse as a marker of cardiac performance in COPD
Eur. Respir. J., November 1, 2008; 32(5): 1275 - 1282.
[Abstract] [Full Text] [PDF]

Home page
 ChestHome page
C. Casanova, C. Cote, J. M. Marin, V. Pinto-Plata, J. P. de Torres, A. Aguirre-Jaime, C. Vassaux, and B. R. Celli
Distance and Oxygen Desaturation During the 6-min Walk Test as Predictors of Long-term Mortality in Patients With COPD
Chest, October 1, 2008; 134(4): 746 - 752.
[Abstract] [Full Text] [PDF]

Home page
 ChestHome page
B. R. Celli
Update on the Management of COPD
Chest, June 1, 2008; 133(6): 1451 - 1462.
[Abstract] [Full Text] [PDF]

Home page
 ChestHome page
J. P. de Torres, V. Pinto-Plata, C. Casanova, H. Mullerova, E. Cordoba-Lanus, M. Muros de Fuentes, A. Aguirre-Jaime, and B. R. Celli
C-Reactive Protein Levels and Survival in Patients With Moderate to Very Severe COPD
Chest, June 1, 2008; 133(6): 1336 - 1343.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
A. Agusti
Physical Activity and Chronic Obstructive Pulmonary Disease
Am. J. Respir. Crit. Care Med., April 1, 2008; 177(7): 675 - 676.
[Full Text] [PDF]

Home page
 Eur Respir JHome page
C. G. Cote, C. Casanova, J. M. Marin, M. V. Lopez, V. Pinto-Plata, M. M. de Oca, L. J. Dordelly, H. Nekach, and B. R. Celli
Validation and comparison of reference equations for the 6-min walk distance test
Eur. Respir. J., March 1, 2008; 31(3): 571 - 578.
[Abstract] [Full Text] [PDF]

Home page
 Eur Respir JHome page
M. Cazzola, W. MacNee, F. J. Martinez, K. F. Rabe, L. G. Franciosi, P. J. Barnes, V. Brusasco, P. S. Burge, P. M. A. Calverley, B. R. Celli, et al.
Outcomes for COPD pharmacological trials: from lung function to biomarkers
Eur. Respir. J., February 1, 2008; 31(2): 416 - 469.
[Abstract] [Full Text] [PDF]

Home page
 Chronic Respiratory DiseaseHome page
M. Poulain, M. Doucet, V. Drapeau, G. Fournier, A. Tremblay, P. Poirier, and F. Maltais
Metabolic and inflammatory profile in obese patients with chronic obstructive pulmonary disease
Chronic Respiratory Disease, February 1, 2008; 5(1): 35 - 41.
[Abstract] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
T. Welte
Acute Exacerbation of Chronic Obstructive Pulmonary Disease: More a Functional than an Inflammatory Problem?
Am. J. Respir. Crit. Care Med., January 15, 2008; 177(2): 130 - 131.
[Full Text] [PDF]

Home page
 Proc Am Thorac SocHome page
A. Agusti
Systemic Effects of Chronic Obstructive Pulmonary Disease: What We Know and What We Don't Know (but Should)
Proceedings of the ATS, October 1, 2007; 4(7): 522 - 525.
[Abstract] [Full Text] [PDF]

Home page
 ChestHome page
E. F. M. Wouters
Decision Making in Chronic Hypercapnic Respiratory Failure: A Real Challenge!
Chest, June 1, 2007; 131(6): 1622 - 1624.
[Full Text] [PDF]

Home page
 ChestHome page
S. Budweiser, R. A. Jorres, T. Riedl, F. Heinemann, A. P. Hitzl, W. Windisch, and M. Pfeifer
Predictors of Survival in COPD Patients With Chronic Hypercapnic Respiratory Failure Receiving Noninvasive Home Ventilation
Chest, June 1, 2007; 131(6): 1650 - 1658.
[Abstract] [Full Text] [PDF]

Home page
 Eur Respir JHome page
C. Casanova, C. G. Cote, J. M. Marin, J. P. de Torres, A. Aguirre-Jaime, R. Mendez, L. Dordelly, and B. R. Celli
The 6-min walking distance: long-term follow up in patients with COPD
Eur. Respir. J., March 1, 2007; 29(3): 535 - 540.
[Abstract] [Full Text] [PDF]

Home page
 Eur Respir JHome page
P. Palange, S. A. Ward, K-H. Carlsen, R. Casaburi, C. G. Gallagher, R. Gosselink, D. E. O'Donnell, L. Puente-Maestu, A. M. Schols, S. Singh, et al.
Recommendations on the use of exercise testing in clinical practice
Eur. Respir. J., January 1, 2007; 29(1): 185 - 209.
[Abstract] [Full Text] [PDF]

Home page
 ERRHome page
D. E. O'Donnell and P. Laveneziana
Physiology and consequences of lung hyperinflation in COPD
Eur. Respir. Rev., December 1, 2006; 15(100): 61 - 67.
[Abstract] [Full Text] [PDF]

Home page
 ERRHome page
S. Budweiser, RudolfA. Jorres, T. Riedl, F. Heinemann, and M. Pfeifer
Base excess, a marker of chronic hypercapnic respiratory failure and predictor of survival in COPD
Eur. Respir. Rev., December 1, 2006; 15(101): 194 - 196.
[Abstract] [Full Text] [PDF]

Home page
 ThoraxHome page
P Boschetto, S Quintavalle, E Zeni, S Leprotti, A Potena, L Ballerin, A Papi, G Palladini, M Luisetti, L Annovazzi, et al.
Association between markers of emphysema and more severe chronic obstructive pulmonary disease
Thorax, December 1, 2006; 61(12): 1037 - 1042.
[Abstract] [Full Text] [PDF]

Home page
 Eur Respir JHome page
A. L. P. Albuquerque, L. E. Nery, D. S. Villaca, T. Y. S. Machado, C. C. Oliveira, A. T. Paes, and J. A. Neder
Inspiratory fraction and exercise impairment in COPD patients GOLD stages II-III
Eur. Respir. J., November 1, 2006; 28(5): 939 - 944.
[Abstract] [Full Text] [PDF]

Home page
 Proc Am Thorac SocHome page
B. R. Celli
Roger S. Mitchell Lecture. Chronic Obstructive Pulmonary Disease Phenotypes and Their Clinical Relevance
Proceedings of the ATS, August 1, 2006; 3(6): 461 - 465.
[Abstract] [Full Text] [PDF]

Home page
 Proc Am Thorac SocHome page
W. MacNee
Conference Summary
Proceedings of the ATS, August 1, 2006; 3(6): 539 - 542.
[Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
B. R. Celli
Predicting mortality in chronic obstructive pulmonary disease: chasing the "holy grail".
Am. J. Respir. Crit. Care Med., June 15, 2006; 173(12): 1298 - 1299.
[Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
F. J. Martinez, G. Foster, J. L. Curtis, G. Criner, G. Weinmann, A. Fishman, M. M. DeCamp, J. Benditt, F. Sciurba, B. Make, et al.
Predictors of Mortality in Patients with Emphysema and Severe Airflow Obstruction
Am. J. Respir. Crit. Care Med., June 15, 2006; 173(12): 1326 - 1334.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
L. M. Fabbri, F. Luppi, B. Beghe, and K. F. Rabe
Update in chronic obstructive pulmonary disease 2005.
Am. J. Respir. Crit. Care Med., May 15, 2006; 173(10): 1056 - 1065.
[Full Text] [PDF]

Home page
 Eur Respir JHome page
S. Marti, X. Munoz, J. Rios, F. Morell, and J. Ferrer
Body weight and comorbidity predict mortality in COPD patients treated with oxygen therapy.
Eur. Respir. J., April 1, 2006; 27(4): 689 - 696.
[Abstract] [Full Text] [PDF]

Home page
 ChestHome page
D. E. O'Donnell
Is Sustained Pharmacologic Lung Volume Reduction Now Possible in COPD?
Chest, March 1, 2006; 129(3): 501 - 503.
[Full Text] [PDF]

Home page
 Proc Am Thorac SocHome page
B. R. Celli
Chronic Obstructive Pulmonary Disease: From Unjustified Nihilism to Evidence-based Optimism.
Proceedings of the ATS, January 1, 2006; 3(1): 58 - 65.
[Abstract] [Full Text] [PDF]

Home page
 Proc Am Thorac SocHome page
C. L. Rochester
Clinical Year in Review IV: Asthma, Chronic Obstructive Pulmonary Disease, Exercise and Rehabilitation, and Critical Care Medicine
Proceedings of the ATS, December 1, 2005; 2(6): 461 - 465.
[Full Text] [PDF]

Home page
 Eur Respir JHome page
R. Pellegrino, G. Viegi, V. Brusasco, R. O. Crapo, F. Burgos, R. Casaburi, A. Coates, C. P. M. van der Grinten, P. Gustafsson, J. Hankinson, et al.
Interpretative strategies for lung function tests
Eur. Respir. J., November 1, 2005; 26(5): 948 - 968.
[Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH
Proc. Am. Thorac. Soc. Am. J. Respir. Cell Mol. Biol.
Copyright © 2004 American Thoracic Society 		  ATS Quiz on Sleep Study Tracings