Published ahead of print on September 24, 2004, doi:10.1164/rccm.200406-698OC
Am. J. Respir. Crit. Care Med., Volume 171, Number 1, January 2005, 19-25
A more recent version of this article appeared on January 1, 2005
Submitted on June 2, 2004
Accepted on September 22, 2004
Allergen-exposure of Mouse Airways Evokes Remodeling of both Bronchi and Large Pulmonary Vessels
Kristina Rydell Tormanen1*, Lena Uller1, Carl GA Persson2, and Jonas S Erjefalt1
1 Department of Physiological Sciences, Lund University, Lund, Sweden,
2 Department of Clinical Pharmacology, Lund University Hospital, Lund, Sweden
* To whom correspondence should be addressed. E-mail: Kristina.Rydell{at}mphy.lu.se.
Remodeling of airway structures is a well-documented feature of allergic airway inflammation. To investigate if bronchial remodeling is associated with remodeling of adjacent pulmonary vessels, sensitized mice were subjected to repeated ovalbumin inhalations, and bronchi and pulmonary vessels subjected to histological analysis. Allergen challenges induced peribronchial as well as perivascular eosinophilia. Remodeling of systemic airway microcirculation, as studied in tracheal whole-mount preparations, revealed an allergen-induced increase in both diameter and length of the airway microvessels. Immunostaining for  -smooth muscle actin disclosed an increase in smooth muscle mass in both bronchi and large pulmonary vessels. Both bronchi and pulmonary vessels also displayed increased expression of procollagen I and III. Staining for Proliferating Cell Nuclear Antigen revealed increased proliferation of bronchial epithelial and smooth muscle cells as well as pulmonary vascular endothelial and smooth muscle cells. We conclude that central features of remodeling, that take place in allergen-exposed airways, are present also in the pulmonary vessels. The significance of this finding with respect to occurrence in disease, pathophysiologic importance, and involved mechanisms warrants further investigation.
Key words: Asthma, Vascular remodeling, Eosinophils, Animal model
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