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Published ahead of print on November 19, 2004, doi:10.1164/rccm.200405-674OC

Am. J. Respir. Crit. Care Med., Volume 171, Number 4, February 2005, 334-339

A more recent version of this article appeared on February 15, 2005
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Submitted on June 1, 2004
Accepted on November 15, 2004

Asthma Severity is Associated with Body Mass Index and Early Menarche in Women

Raphaelle Varraso1*, Valerie Siroux2, Jean Maccario1, Isabelle Pin3, and Francine Kauffmann1

1 Department of Epidemiology and Biostatistics, INSERM U472-IFR 69, Villejuif, France, 2 Department of Epidemiology and Biostatistics, INSERM U472-IFR 69, Villejuif, France; Grenoble CHU, Grenoble, France, 3 Grenoble CHU, Grenoble, France

* To whom correspondence should be addressed. E-mail: varraso{at}vjf.inserm.fr.

Asthma severity in relation to body mass index (BMI) has rarely been studied. The relation between BMI and asthma severity was studied by sex in 366 adult asthmatics from the Epidemiological study on the Genetics and Environment of Asthma, (EGEA), a case control and family study on asthma. Factors related to asthma severity and BMI such as smoking, FEV1, bronchial hyperresponsiveness (BHR) and dyspnea were taken into account. The influence of early menarche was studied to assess the potential role of hormonal factors. Clinical asthma severity in the last 12 months was assessed by a score (0-7), based on the frequency of asthma attacks, persisting symptoms between attacks and hospitalization. Asthma severity which was unrelated to gender, increased with BMI in women (p=0.0001), but not in men (p=0.3). In women, the association remained after adjustment on age, FEV1, smoking habits, BMI-adjusted dyspnea and taking into account familial dependence (p=0.0001). The association between BMI and severity was stronger in women with early menarche than in women without early menarche (p interaction = 0.02). Findings support the hypothesis of hormonal factors involved in the severity of asthma.
Key words: asthma severity, body mass index, gender, menarche




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