help button home button
AJRCCM
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH
Published ahead of print on July 21, 2004, doi:10.1164/rccm.200405-575OC

Am. J. Respir. Crit. Care Med., Volume 170, Number 9, November 2004, 1000-1005

A more recent version of this article appeared on November 1, 2004
This Article
Right arrow Full Text (PDF)
Right arrow All Versions of this Article:
200405-575OCv1
170/9/1000    most recent
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Griese, M.
Right arrow Articles by Paul, K.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Griese, M.
Right arrow Articles by Paul, K.

Submitted on May 10, 2004
Accepted on July 16, 2004

Pulmonary Surfactant, Lung Function and Endobronchial Inflammation in Cystic Fibrosis

Matthias Griese1*, Robert Essl1, Reinhold Schmidt1, Ernst Rietschel1, Felix Ratjen1, Manfred Ballmann1, and Karl Paul1

1 Department of Pediatrics, Ludwig-Maximilians-University, Munich, Germany

* To whom correspondence should be addressed. E-mail: griese{at}pk-i.med.uni-muenchen.de.

Cystic fibrosis (CF) lung disease is primarily a disease of the small airways. We hypothesized that even in patients with normal lung function, a reduced surfactant function would be present and favor small airway obstruction. Bronchoalveolar lavages from 76 CF patients (5-31 years, median 11) with well conserved lung function (FEV1 94% pred. (range 78-121) and from 10 healthy control subjects were investigated. The deviation of the biophysical surfactant performance from normal, assessed in a bubble surfactometer, was small, however the ability of the surfactant to maintain the patency of a narrow airway (% open) was significantly reduced. Surfactant protein (SP)-C level were increased, SP-B and SP-D were unchanged, whereas SP-A was decreased. Among the CF-patients neutrophilic inflammation was modestly related to a poorer surfactant activity, but not to lung function. SP-D was reduced in proportion to the degree of inflammation and in the presence of bacteria. These findings in a large cohort of CF patients with normal lung function show that the endobronchial airway inflammation is linked to early perturbations of the biophysical properties and immunological components of pulmonary surfactant and opens fields for novel therapeutic interventions.
Key words: surface activity, pulsating bubble, capillary surfactometer, bronchoalveolar lavage, airway inflammation




This article has been cited by other articles:


Home page
 Therapeutic Advances in Respiratory DiseaseHome page
D. D. Sin, P. S. Pahlavan, and S.F. P. Man
Review: Surfactant protein D: A lung specific biomarker in COPD?
Therapeutic Advances in Respiratory Disease, April 1, 2008; 2(2): 65 - 74.
[Abstract] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
D. Huh, H. Fujioka, Y.-C. Tung, N. Futai, R. Paine III, J. B. Grotberg, and S. Takayama
Acoustically detectable cellular-level lung injury induced by fluid mechanical stresses in microfluidic airway systems
PNAS, November 27, 2007; 104(48): 18886 - 18891.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
H. R. S. Tagaram, G. Wang, T. M. Umstead, A. N. Mikerov, N. J. Thomas, G. R. Graff, J. C. Hess, M. J. Thomassen, M. S. Kavuru, D. S. Phelps, et al.
Characterization of a human surfactant protein A1 (SP-A1) gene-specific antibody; SP-A1 content variation among individuals of varying age and pulmonary health
Am J Physiol Lung Cell Mol Physiol, May 1, 2007; 292(5): L1052 - L1063.
[Abstract] [Full Text] [PDF]

Home page
 Infect. Immun.Home page
A. N. Mikerov, G. Wang, T. M. Umstead, M. Zacharatos, N. J. Thomas, D. S. Phelps, and J. Floros
Surfactant Protein A2 (SP-A2) Variants Expressed in CHO Cells Stimulate Phagocytosis of Pseudomonas aeruginosa More than Do SP-A1 Variants
Infect. Immun., March 1, 2007; 75(3): 1403 - 1412.
[Abstract] [Full Text] [PDF]

Home page
 J. Nutr.Home page
S. M. Innis and D. Hasman
Evidence of Choline Depletion and Reduced Betaine and Dimethylglycine with Increased Homocysteine in Plasma of Children with Cystic Fibrosis
J. Nutr., August 1, 2006; 136(8): 2226 - 2231.
[Abstract] [Full Text] [PDF]

Home page
 ChestHome page
V. Starosta, E. Rietschel, K. Paul, U. Baumann, and M. Griese
Oxidative Changes of Bronchoalveolar Proteins in Cystic Fibrosis.
Chest, February 1, 2006; 129(2): 431 - 437.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
H. Grasemann, R. Schwiertz, S. Matthiesen, K. Racke, and F. Ratjen
Increased Arginase Activity in Cystic Fibrosis Airways
Am. J. Respir. Crit. Care Med., December 15, 2005; 172(12): 1523 - 1528.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
A. Bush, F. Accurso, W. MacNee, S. C. Lazarus, and E. Abraham
Cystic Fibrosis, Pediatrics, Control of Breathing, Pulmonary Physiology and Anatomy, and Surfactant Biology in AJRCCM in 2004
Am. J. Respir. Crit. Care Med., March 15, 2005; 171(6): 545 - 553.
[Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH
Proc. Am. Thorac. Soc. Am. J. Respir. Cell Mol. Biol.
Copyright © 2004 American Thoracic Society 		  ATS Best of the Web