help button home button
AJRCCM
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH
Published ahead of print on December 3, 2004, doi:10.1164/rccm.200404-558OC

Am. J. Respir. Crit. Care Med., Volume 171, Number 8, April 2005, 838-843

A more recent version of this article appeared on April 15, 2005
This Article
Right arrow Full Text (PDF)
Right arrow All Versions of this Article:
200404-558OCv1
171/8/838    most recent
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Santus, P.
Right arrow Articles by Sala, A.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Santus, P.
Right arrow Articles by Sala, A.

Submitted on May 11, 2004
Accepted on November 26, 2004

Lipid Peroxidation and 5-lipoxygenase Activity in Chronic Obstructive Pulmonary Disease Subjects

Pierachille Santus1, Alessandra Sola2, Paolo Carlucci1, Francesca Fumagalli2, Antonio Di Gennaro2, Michele Mondoni1, Chiara Carnini2, Stefano Centanni1, and Angelo Sala2*

1 Institute of Respiratory Medicine, Ospedale S. Paolo, University of Milan, Milan, Italy, 2 Department of Pharmacological Sciences, Center for Cardiopulmonary, University of Milan, Milan, Italy

* To whom correspondence should be addressed. E-mail: angelo.sala{at}unimi.it.

We studied the urinary excretion of the isoprostane 8-iso-Prostaglandin F2{alpha}, as an index of in vivo oxidant stress, and the production of leukotriene B4 (LTB4) by neutrophils in chronic obstructive pulmonary disease (COPD) and normal subjects. Overnight urinary excretion of the isoprostane resulted significantly higher in COPD patients than in controls, and LTB4 production by challenge of neutrophils obtained from COPD patients also resulted significantly higher than that observed in control neutrophils. Treatment with a standardized polyphenol extract caused a significant decrease in isoprostane excretion, accompanied by statistically significant increase of partial pressure of arterial oxygen. Furthermore, changes in FEV1 significantly correlated with the changes in isoprostane urinary excretion observed from enrollment to the end of treatment. The results of this study suggest that enhanced oxidative stress in COPD subjects is paralleled by the increased ability of neutrophil to synthesize the chemotactic factor LTB4, and may ultimately contribute to the infiltration/activation of neutrophils into the airways of COPD subjects. Antioxidant treatment in COPD subjects is effective in reducing oxidant stress, as shown by the decrease of urinary isoprostane, a reduction that correlates with the severity of the disease, as indicated by changes in partial pressure of arterial oxygen and FEV1
Key words: neutrophils, leukotriene B4, oxidative stress, natural polyphenols, urinary isoprostanes




This article has been cited by other articles:


Home page
 Therapeutic Advances in Respiratory DiseaseHome page
I. Rahman
Review: Antioxidant therapeutic advances in COPD
Therapeutic Advances in Respiratory Disease, December 1, 2008; 2(6): 351 - 374.
[Abstract] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
P. Szulakowski, A. J. L. Crowther, L. A. Jimenez, K. Donaldson, R. Mayer, T. B. Leonard, W. MacNee, and E. M. Drost
The Effect of Smoking on the Transcriptional Regulation of Lung Inflammation in Patients with Chronic Obstructive Pulmonary Disease
Am. J. Respir. Crit. Care Med., July 1, 2006; 174(1): 41 - 50.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
L. M. Fabbri, F. Luppi, B. Beghe, and K. F. Rabe
Update in chronic obstructive pulmonary disease 2005.
Am. J. Respir. Crit. Care Med., May 15, 2006; 173(10): 1056 - 1065.
[Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
K. Juul, A. Tybjaerg-Hansen, S. Marklund, P. Lange, and B. G. Nordestgaard
Genetically Increased Antioxidative Protection and Decreased Chronic Obstructive Pulmonary Disease
Am. J. Respir. Crit. Care Med., April 15, 2006; 173(8): 858 - 864.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
R. F. Foronjy, O. Mirochnitchenko, O. Propokenko, V. Lemaitre, Y. Jia, M. Inouye, Y. Okada, and J. M. D'Armiento
Superoxide Dismutase Expression Attenuates Cigarette Smoke- or Elastase-generated Emphysema in Mice
Am. J. Respir. Crit. Care Med., March 15, 2006; 173(6): 623 - 631.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
H. Yasuda, M. Yamaya, K. Nakayama, S. Ebihara, T. Sasaki, S. Okinaga, D. Inoue, M. Asada, M. Nemoto, and H. Sasaki
Increased Arterial Carboxyhemoglobin Concentrations in Chronic Obstructive Pulmonary Disease
Am. J. Respir. Crit. Care Med., June 1, 2005; 171(11): 1246 - 1251.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH
Proc. Am. Thorac. Soc. Am. J. Respir. Cell Mol. Biol.
Copyright © 2004 American Thoracic Society 		  ATS State of the Art 2009