Published ahead of print on December 10, 2004, doi:10.1164/rccm.200404-530OC Am. J. Respir. Crit. Care Med., Volume 171, Number 7, April 2005, 773-779 A more recent version of this article appeared on April 1, 2005
Submitted on April 26, 2004 Polymorphisms in the CD14 Gene are Associated with Pulmonary Function in FarmersTricia D LeVan1,1 Arizona Respiratory Center and Departments of Internal Medicine, University of Arizona, Tucson, AZ, USA, 2 Department of Internal Medicine, Pulmonary and Critical Care Medicine Section, University of Nebraska, Omaha, NE, USA, 3 Department of Exercise Science and Athletic Training, Creighton University, Omaha, NE, USA, 4 Department of Pediatrics, University of Arizona, Tucson, AZ, USA, 5 Department of Occupational and Environmental Health, University of Iowa, College of Public Health, Iowa City, IA, USA * To whom correspondence should be addressed. E-mail: svonesse{at}unmc.edu.
Farmers experience airway obstruction, which may be attributable, in part, to endotoxin inhalation. CD14 is a receptor for endotoxin. Based on our findings of increased circulating CD14 associated with the CD14/-159 T allele, we hypothesized that carriers of this allele would have decreased lung function among endotoxin exposed individuals. CD14/-159TT farmers (n = 19) had significantly lower lung function as measured by FEV1 (p = 0.028) and FEF25-75 (p = 0.05) compared to farmers with the C allele (n = 78). Also, farmers with the CD14/-1619GG genotype (n =11) were associated with lower lung function (FEV1, p = 0.008; FEF25-75, p = 0.009) compared to farmers with the A allele (n = 86). No association between CD14/-550 and lung function was observed (FEV1, p = 0.32; FEF25-75, p = 0.11). Increased prevalence of wheezing was reported in farmers homozygous for CD14/-159T (p = 0.013) and/or CD14/-1619G (p = 0.019) compared to farmers with the CC or AA genotype, respectively. No association was found between TLR4/Asp299Gly and lung function or wheeze. We conclude that the CD14/-159 and/or CD14/-1619 loci may play a role in modulating lung function and wheeze among agricultural workers. Key words: Endotoxin, Lipopolysaccharide, Occupational Exposure, Farming, Wheeze
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