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Published ahead of print on November 5, 2004, doi:10.1164/rccm.200402-220OC

Am. J. Respir. Crit. Care Med., Volume 171, Number 2, January 2005, 121-128

A more recent version of this article appeared on January 15, 2005
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Submitted on February 23, 2004
Accepted on October 29, 2004

Antioxidant Intake in Pregnancy in Relation to Wheeze and Eczema in the First Two Years of Life

Sheelagh Martindale1*, Geraldine McNeill2, Graham Devereux1, Doris Campbell3, George Russell4, and Anthony Seaton1

1 Department of Environmental and Occupational Medicine, University of Aberdeen, Aberdeen, Scotland, United Kingdom, 2 Department of Environmental and Occupational Medicine, University of Aberdeen, Aberdeen, Scotland, United Kingdom; Department of Child Health, University of Aberdeen, Aberdeen, Scotland, United Kingdom, 3 Department of Obstetrics, University of Aberdeen, Aberdeen, Scotland, United Kingdom, 4 Department of Child Health, University of Aberdeen, Aberdeen, Scotland, United Kingdom

* To whom correspondence should be addressed. E-mail: s.martindale{at}rgu.ac.uk.

2,000 women were recruited for a prospective investigation of the influence of maternal antioxidant intake in pregnancy on the development of asthma and eczema in young children. A food frequency questionnaire was used to characterise diet during pregnancy and blood antioxidant levels were measured. Postal questionnaires were used to follow up the 1,924 singleton children born to the cohort at 6, 12 and 24 months of age. There were no associations between maternal antioxidant intake and wheezing symptoms and eczema in the children's first year. In the children's second year, maternal vitamin E intake during pregnancy was negatively associated with wheeze in the absence of a 'cold' (p for trend 0.010) and, in children whose mothers were atopic, there was a negative association between maternal vitamin E intake and childhood eczema (p for trend 0.024). Maternal vitamin C intake during pregnancy was positively associated with 'ever wheeze' and eczema during the children's second year. This study suggests that maternal dietary antioxidant intakes during pregnancy may modify the risks of developing wheeze and eczema during early childhood. Further follow up of the cohort will determine whether maternal diet during pregnancy is associated with asthma and atopic diseases in later childhood.
Key words: asthma, atopy, diet, pregnancy, vitamins




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