help button home button
AJRCCM
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH
Published ahead of print on September 10, 2004, doi:10.1164/rccm.200402-193OC

Am. J. Respir. Crit. Care Med., Volume 170, Number 12, December 2004, 1354-1359

A more recent version of this article appeared on December 15, 2004
This Article
Right arrow Full Text (PDF)
Right arrow All Versions of this Article:
200402-193OCv1
170/12/1354    most recent
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Tazaki, T.
Right arrow Articles by Adachi, M.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Tazaki, T.
Right arrow Articles by Adachi, M.

Submitted on February 16, 2004
Accepted on September 4, 2004

Increased Levels and Activity of Matrix Metalloproteinase-9 in Obstructive Sleep Apnea Syndrome

Toshiyuki Tazaki1, Kenji Minoguchi1*, Takuya Yokoe1, Karen TR Samson1, Hideko Minoguchi1, Akihiro Tanaka1, Yoshio Watanabe1, and Mitsuru Adachi1

1 First Department of Internal Medicine, Showa University, Tokyo, Japan

* To whom correspondence should be addressed. E-mail: minochan{at}fn.catv.ne.jp.

Matrix metalloproteinases (MMPs) are involved in the pathogenesis of cardiovascular diseases. We examined serum levels of MMP-9 and its inhibitor, tissue inhibitor of metalloproteinase-1 (TIMP-1), activity of MMP-9, and the effect of nasal continuous positive airway pressure (nCPAP) in patients with obstructive sleep apnea syndrome (OSAS). After polysomnography venous blood was collected at 5 a.m. from 44 patients with OSAS and 18 obese control subjects, and serum levels of MMP-9, TIMP-1, and enzymatic activity of MMP-9 were measured. In addition, the effects of 1 months[[rad]] treatment with nCPAP were studied in patients with moderate to severe OSAS. Although serum levels of MMP-9 (p < 0.05) and MMP-9 activity (p < 0.01) were higher in patients with OSAS than in obese control subjects, TIMP-1 levels did not differ significantly. In patients with OSAS the severity of OSAS was the primary factor influencing levels (p < 0.01) and activity (p < 0.01) of MMP-9. nCPAP significantly decreased serum levels (p < 0.01) and activity (p < 0.001) of MMP-9 but not affect TIMP-1 levels. Therefore, OSAS may increase risks of cardiovascular morbidity, and nCPAP might be useful for decreasing these risks.
Key words: Sleep apnea, cardiovascular disease, metalloproteinase, atherosclerosis, cytokine




This article has been cited by other articles:


Home page
 Proc Am Thorac SocHome page
M. H. Sanders, J. M. Montserrat, R. Farre, and R. J. Givelber
Positive Pressure Therapy: A Perspective on Evidence-based Outcomes and Methods of Application
Proceedings of the ATS, February 15, 2008; 5(2): 161 - 172.
[Abstract] [Full Text] [PDF]

Home page
 ERRHome page
I. A. Harsch
Metabolic disturbances in patients with obstructive sleep apnoea syndrome
Eur. Respir. Rev., December 1, 2007; 16(106): 196 - 202.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
K. Minoguchi, T. Yokoe, T. Tazaki, H. Minoguchi, N. Oda, A. Tanaka, M. Yamamoto, S. Ohta, C. P. O'Donnell, and M. Adachi
Silent Brain Infarction and Platelet Activation in Obstructive Sleep Apnea
Am. J. Respir. Crit. Care Med., March 15, 2007; 175(6): 612 - 617.
[Abstract] [Full Text] [PDF]

Home page
 Eur Respir JHome page
K. Minoguchi, T. Yokoe, A. Tanaka, S. Ohta, T. Hirano, G. Yoshino, C. P. O'Donnell, and M. Adachi
Association between lipid peroxidation and inflammation in obstructive sleep apnoea.
Eur. Respir. J., August 1, 2006; 28(2): 378 - 385.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
K. Minoguchi, T. Yokoe, T. Tazaki, H. Minoguchi, A. Tanaka, N. Oda, S. Okada, S. Ohta, H. Naito, and M. Adachi
Increased Carotid Intima-Media Thickness and Serum Inflammatory Markers in Obstructive Sleep Apnea
Am. J. Respir. Crit. Care Med., September 1, 2005; 172(5): 625 - 630.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
M. John and K. Jung
Consideration of Important Preanalytical Conditions for the Assessment of Circulating Matrix Metalloproteinase-9
Am. J. Respir. Crit. Care Med., July 15, 2005; 172(2): 254 - 254.
[Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
K. Minoguchi
Consideration of Important Preanalytical Conditions for the Assessment of Circulating Matrix Metalloproteinase-9
Am. J. Respir. Crit. Care Med., July 15, 2005; 172(2): 254 - 254.
[Full Text] [PDF]

Home page
 Eur Respir JHome page
R. Schulz
The vascular micromilieu in obstructive sleep apnoea
Eur. Respir. J., May 1, 2005; 25(5): 780 - 782.
[Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
T. D. Bradley, Y. E. Miller, F. J. Martinez, D. C. Angus, W. MacNee, and E. Abraham
Interstitial Lung Disease, Lung Cancer, Lung Transplantation, Pulmonary Vascular Disorders, and Sleep-disordered Breathing in AJRCCM in 2004
Am. J. Respir. Crit. Care Med., April 1, 2005; 171(7): 675 - 685.
[Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH
Proc. Am. Thorac. Soc. Am. J. Respir. Cell Mol. Biol.
Copyright © 2004 American Thoracic Society 		  ATS State of the Art Course 2008