help button home button
AJRCCM
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH
Published ahead of print on April 1, 2004, doi:10.1164/rccm.200402-179OC

Am. J. Respir. Crit. Care Med., Volume 170, Number 1, July 2004, 59-64

A more recent version of this article appeared on July 1, 2004
This Article
Right arrow Full Text (PDF)
Right arrow All Versions of this Article:
200402-179OCv1
170/1/59    most recent
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Mori, T.
Right arrow Articles by Tsuyuguchi, I.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Mori, T.
Right arrow Articles by Tsuyuguchi, I.

Submitted on February 10, 2004
Accepted on March 26, 2004

Specific Detection of Tuberculosis Infection with an Interferon-gamma Based Assay Using New Antigens

Toru Mori1*, Mitsunori Sakatani2, Fumio Yamagishi3, Tetsuya Takashima4, Yoshiko Kawabe5, Keiji Nagao6, Eriko Shigeto7, Nobuyuki Harada1, Satoshi Mitarai1, Masaji Okada2, Katsuhiro Suzuki2, Yoshikazu Inoue2, Kazunari Tsuyuguchi2, Yuka Sasaki3, Gerald H Mazurek8, and Izuo Tsuyuguchi4

1 Research Institute of Tuberculosis, Tokyo, Japan, 2 National Kinki Chuo Hospital for Chest Diseases, Osaka, Japan, 3 National Chiba Higashi Hospital, Chiba, Japan, 4 Osaka Prefectural Habikino Hospital, Osaka, Japan, 5 National Tokyo Hospital, Tokyo, Japan, 6 Chiba University School of Medicine, Chiba, Japan, 7 National Hiroshima Hospital, Hiroshima, Japan, 8 Centers for Disease Control and Prevention, Altlanta, GA, USA

* To whom correspondence should be addressed. E-mail: tmori{at}jata.or.jp.

The tuberculin skin test for immunologic diagnosis of Mycobacterium tuberculosis infection has many limitations, including being confounded by Bacillus Calmette-Guerin (BCG) vaccination or exposure to non- tuberculous mycobacteria. M. tuberculosis-specific antigens that are absent from BCG and most non-tuberculous mycobacteria have recently been identified. We examined the use of two of these antigens, CFP-10 and ESAT-6, in a whole blood interferon-g assay as a diagnostic test for tuberculosis in BCG vaccinated individuals. Due to lack of an accurate standard with which to compare new tests for M. tuberculosis infection, specificity of the whole blood interferon-g assay was estimated using data from people with no identified risk for M. tuberculosis exposure (216 BCG vaccinated Japanese adults) and sensitivity was estimated using data from 118 patients with culture confirmed M. tuberculosis infection who had received less than one week of treatment. Using a combination of CFP-10 and ESAT-6 responses, the specificity of the test in the low risk people was 98.1% and the sensitivity in patients with M. tuberculosis infection was 89.0%. The results demonstrate that the whole blood IFN-{gamma} assay using CFP-10 and ESAT-6 was highly specific and sensitive for M. tuberculosis infection and was unaffected by BCG vaccination status.
Key words: Tuberculosis, Diagnostics, Infection, Interferon-gamma, BCG




This article has been cited by other articles:


Home page
 ANN INTERN MEDHome page
M. Pai, A. Zwerling, and D. Menzies
Systematic Review: T-Cell-based Assays for the Diagnosis of Latent Tuberculosis Infection: An Update
Ann Intern Med, August 5, 2008; 149(3): 177 - 184.
[Abstract] [Full Text] [PDF]

Home page
 ChestHome page
J.-P. Janssens
Clinical Utility of the Interferon-{gamma} Release Assay for Elderly Patients With Active Tuberculosis: A Word of Caution
Chest, August 1, 2008; 134(2): 471 - 472.
[Full Text] [PDF]

Home page
 J. Clin. Microbiol.Home page
C. B. E. Chee, S. H. Gan, K. W. KhinMar, T. M. Barkham, C. K. Koh, S. Liang, and Y. T. Wang
Comparison of Sensitivities of Two Commercial Gamma Interferon Release Assays for Pulmonary Tuberculosis
J. Clin. Microbiol., June 1, 2008; 46(6): 1935 - 1940.
[Abstract] [Full Text] [PDF]

Home page
 ChestHome page
J. C. Choi, J. W. Shin, J. Y. Kim, I. W. Park, B. W. Choi, and M.-K. Lee
The Effect of Previous Tuberculin Skin Test on the Follow-up Examination of Whole-Blood Interferon-{gamma} Assay in the Screening for Latent Tuberculosis Infection
Chest, June 1, 2008; 133(6): 1415 - 1420.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
R. Diel, R. Loddenkemper, K. Meywald-Walter, S. Niemann, and A. Nienhaus
Predictive Value of a Whole Blood IFN-{gamma} Assay for the Development of Active Tuberculosis Disease after Recent Infection with Mycobacterium tuberculosis
Am. J. Respir. Crit. Care Med., May 15, 2008; 177(10): 1164 - 1170.
[Abstract] [Full Text] [PDF]

Home page
 ChestHome page
Y. Kobashi, K. Mouri, S. Yagi, Y. Obase, N. Miyashita, N. Okimoto, T. Matsushima, T. Kageoka, and M. Oka
Clinical Utility of the QuantiFERON TB-2G Test for Elderly Patients With Active Tuberculosis
Chest, May 1, 2008; 133(5): 1196 - 1202.
[Abstract] [Full Text] [PDF]

Home page
 ANN INTERN MEDHome page
D. P.S. Dosanjh, T. S.C. Hinks, J. A. Innes, J. J. Deeks, G. Pasvol, S. Hackforth, H. Varia, K. A. Millington, R. Gunatheesan, V. Guyot-Revol, et al.
Improved Diagnostic Evaluation of Suspected Tuberculosis
Ann Intern Med, March 4, 2008; 148(5): 325 - 336.
[Abstract] [Full Text] [PDF]

Home page
 Rheumatology (Oxford)Home page
R. Dinser, M. Fousse, U. Sester, K. Albrecht, M. Singh, H. Kohler, U. Muller-Ladner, and M. Sester
Evaluation of latent tuberculosis infection in patients with inflammatory arthropathies before treatment with TNF-{alpha} blocking drugs using a novel flow-cytometric interferon-{gamma} release assay
Rheumatology, February 1, 2008; 47(2): 212 - 218.
[Abstract] [Full Text] [PDF]

Home page
 Obstet GynecolHome page
A Blood Test for Tuberculosis
Obstet. Gynecol., January 1, 2008; 111(1): 207 - 208.
[Full Text] [PDF]

Home page
 Ann Rheum DisHome page
G Matulis, P Juni, P M Villiger, and S D Gadola
Detection of latent tuberculosis in immunosuppressed patients with autoimmune diseases: performance of a Mycobacterium tuberculosis antigen-specific interferon {gamma} assay
Ann Rheum Dis, January 1, 2008; 67(1): 84 - 90.
[Abstract] [Full Text] [PDF]

Home page
 J Am Board Fam MedHome page
M. G. Madariaga, Z. Jalali, and S. Swindells
Clinical Utility of Interferon Gamma Assay in the Diagnosis of Tuberculosis
J Am Board Fam Med, November 1, 2007; 20(6): 540 - 547.
[Abstract] [Full Text] [PDF]

Home page
 Eur Respir JHome page
Y. Kobashi, K. Mouri, Y. Obase, M. Fukuda, N. Miyashita, and M. Oka
Clinical evaluation of QuantiFERON TB-2G test for immunocompromised patients
Eur. Respir. J., November 1, 2007; 30(5): 945 - 950.
[Abstract] [Full Text] [PDF]

Home page
 ChestHome page
Y. A. Kang, H. W. Lee, S. S. Hwang, S.-W. Um, S. K. Han, Y.-S. Shim, and J.-J. Yim
Usefulness of Whole-Blood Interferon-{gamma} Assay and Interferon-{gamma} Enzyme-Linked Immunospot Assay in the Diagnosis of Active Pulmonary Tuberculosis
Chest, September 1, 2007; 132(3): 959 - 965.
[Abstract] [Full Text] [PDF]

Home page
 ChestHome page
A. Lalvani
Diagnosing Tuberculosis Infection in the 21st Century: New Tools To Tackle an Old Enemy
Chest, June 1, 2007; 131(6): 1898 - 1906.
[Abstract] [Full Text] [PDF]

Home page
 Eur Respir JHome page
E. M. S. Leyten, C. Prins, A. W. J. Bossink, S. Thijsen, T. H. M. Ottenhoff, J. T. van Dissel, and S. M. Arend
Effect of tuberculin skin testing on a Mycobacterium tuberculosis-specific interferon-{gamma} assay
Eur. Respir. J., June 1, 2007; 29(6): 1212 - 1216.
[Abstract] [Full Text] [PDF]

Home page
 CVIHome page
A. Cehovin, J. M. Cliff, P. C. Hill, R. H. Brookes, and H. M. Dockrell
Extended Culture Enhances Sensitivity of a Gamma Interferon Assay for Latent Mycobacterium tuberculosis Infection
Clin. Vaccine Immunol., June 1, 2007; 14(6): 796 - 798.
[Abstract] [Full Text] [PDF]

Home page
 Arch DermatolHome page
L. C. Martinez, C. Harrison-Balestra, J. P. Caeiro, and C. H. Nousari
The Role of the QuantiFERON-TB Gold Test as Screening Prior to Administration of Tumor Necrosis Factor Inhibitors
Arch Dermatol, June 1, 2007; 143(6): 809 - 810.
[Full Text] [PDF]

Home page
 ChestHome page
R. Diel, A. Nienhaus, and R. Loddenkemper
Cost-effectiveness of Interferon-{gamma} Release Assay Screening for Latent Tuberculosis Infection Treatment in Germany
Chest, May 1, 2007; 131(5): 1424 - 1434.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
A. F. Luetkemeyer, E. D. Charlebois, L. L. Flores, D. R. Bangsberg, S. G. Deeks, J. N. Martin, and D. V. Havlir
Comparison of an Interferon-{gamma} Release Assay with Tuberculin Skin Testing in HIV-infected Individuals
Am. J. Respir. Crit. Care Med., April 1, 2007; 175(7): 737 - 742.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
S. M. Arend, S. F. T. Thijsen, E. M. S. Leyten, J. J. M. Bouwman, W. P. J. Franken, B. F. P. J. Koster, F. G. J. Cobelens, A.-J. van Houte, and A. W. J. Bossink
Comparison of Two Interferon-{gamma} Assays and Tuberculin Skin Test for Tracing Tuberculosis Contacts
Am. J. Respir. Crit. Care Med., March 15, 2007; 175(6): 618 - 627.
[Abstract] [Full Text] [PDF]

Home page
 ANN INTERN MEDHome page
D. Menzies, M. Pai, and G. Comstock
Meta-analysis: New Tests for the Diagnosis of Latent Tuberculosis Infection: Areas of Uncertainty and Recommendations for Research
Ann Intern Med, March 6, 2007; 146(5): 340 - 354.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
M. X. Rangaka, K. A. Wilkinson, R. Seldon, G. Van Cutsem, G. A. Meintjes, C. Morroni, P. Mouton, L. Diwakar, T. G. Connell, G. Maartens, et al.
Effect of HIV-1 Infection on T-Cell-based and Skin Test Detection of Tuberculosis Infection
Am. J. Respir. Crit. Care Med., March 1, 2007; 175(5): 514 - 520.
[Abstract] [Full Text] [PDF]

Home page
 Ann Rheum DisHome page
P. Efthimiou and S. Sood
QuantiFERON TB Gold Test: the new standard for screening of latent tuberculosis in patients with rheumatoid arthritis?
Ann Rheum Dis, February 1, 2007; 66(2): 276 - 276.
[Full Text] [PDF]

Home page
 CJASNHome page
L. Passalent, K. Khan, R. Richardson, J. Wang, H. Dedier, and M. Gardam
Detecting Latent Tuberculosis Infection in Hemodialysis Patients: A Head-to-Head Comparison of the T-SPOT.TB Test, Tuberculin Skin Test, and an Expert Physician Panel
Clin. J. Am. Soc. Nephrol., January 1, 2007; 2(1): 68 - 73.
[Abstract] [Full Text] [PDF]

Home page
 Eur Respir JHome page
M. Sadatsafavi and M. Najafzadeh
Cost-optimisation of screening for latent tuberculosis in close contacts
Eur. Respir. J., December 1, 2006; 28(6): 1285 - 1285.
[Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
C. Jafari, M. Ernst, B. Kalsdorf, U. Greinert, R. Diel, D. Kirsten, K. Marienfeld, A. Lalvani, and C. Lange
Rapid Diagnosis of Smear-negative Tuberculosis by Bronchoalveolar Lavage Enzyme-linked Immunospot
Am. J. Respir. Crit. Care Med., November 1, 2006; 174(9): 1048 - 1054.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
L. Richeldi
An Update on the Diagnosis of Tuberculosis Infection
Am. J. Respir. Crit. Care Med., October 1, 2006; 174(7): 736 - 742.
[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Microbiol.Home page
S. J. Tsiouris, D. Coetzee, P. L. Toro, J. Austin, Z. Stein, and W. El-Sadr
Sensitivity analysis and potential uses of a novel gamma interferon release assay for diagnosis of tuberculosis.
J. Clin. Microbiol., August 1, 2006; 44(8): 2844 - 2850.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
M. Pai, R. Joshi, S. Dogra, D. K. Mendiratta, P. Narang, S. Kalantri, A. L. Reingold, J. M. Colford Jr., L. W. Riley, and D. Menzies
Serial Testing of Health Care Workers for Tuberculosis Using Interferon-{gamma} Assay
Am. J. Respir. Crit. Care Med., August 1, 2006; 174(3): 349 - 355.
[Abstract] [Full Text] [PDF]

Home page
 Eur Respir JHome page
P. D. O. Davies and F. Drobniewski
The use of interferon-{gamma}-based blood tests for the detection of latent tuberculosis infection.
Eur. Respir. J., July 1, 2006; 28(1): 1 - 3.
[Full Text] [PDF]

Home page
 Eur Respir JHome page
R. Diel, M. Ernst, G. Doscher, L. Visuri-Karbe, U. Greinert, S. Niemann, A. Nienhaus, and C. Lange
Avoiding the effect of BCG vaccination in detecting Mycobacterium tuberculosis infection with a blood test
Eur. Respir. J., July 1, 2006; 28(1): 16 - 23.
[Abstract] [Full Text] [PDF]

Home page
 Eur Respir JHome page
R. Diel, A. Nienhaus, C. Lange, and T. Schaberg
Cost-optimisation of screening for latent tuberculosis in close contacts
Eur. Respir. J., July 1, 2006; 28(1): 35 - 44.
[Abstract] [Full Text] [PDF]

Home page
 Eur Respir JHome page
J. Y. Lee, H. J. Choi, I-N. Park, S-B. Hong, Y-M. Oh, C-M. Lim, S. D. Lee, Y. Koh, W. S. Kim, D. S. Kim, et al.
Comparison of two commercial interferon-{gamma} assays for diagnosing Mycobacterium tuberculosis infection
Eur. Respir. J., July 1, 2006; 28(1): 24 - 30.
[Abstract] [Full Text] [PDF]

Home page
 Eur Respir JHome page
P. Wrighton-Smith and J-P. Zellweger
Direct costs of three models for the screening of latent tuberculosis infection
Eur. Respir. J., July 1, 2006; 28(1): 45 - 50.
[Abstract] [Full Text] [PDF]

Home page
 ThoraxHome page
T G Connell, N Curtis, S C Ranganathan, and J P Buttery
Performance of a whole blood interferon gamma assay for detecting latent infection with Mycobacterium tuberculosis in children
Thorax, July 1, 2006; 61(7): 616 - 620.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
S. T. Anderson, A. J. Williams, J. R. Brown, S. M. Newton, M. Simsova, M. P. Nicol, P. Sebo, M. Levin, R. J. Wilkinson, and K. A. Wilkinson
Transmission of Mycobacterium tuberculosis Undetected by Tuberculin Skin Testing
Am. J. Respir. Crit. Care Med., May 1, 2006; 173(9): 1038 - 1042.
[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Microbiol.Home page
E. M. S. Leyten, B. Mulder, C. Prins, K. Weldingh, P. Andersen, T. H. M. Ottenhoff, J. T. van Dissel, and S. M. Arend
Use of Enzyme-Linked Immunospot Assay with Mycobacterium tuberculosis- Specific Peptides for Diagnosis of Recent Infection with M. tuberculosis after Accidental Laboratory Exposure.
J. Clin. Microbiol., March 1, 2006; 44(3): 1197 - 1201.
[Abstract] [Full Text] [PDF]

Home page
 Arch Pediatr Adolesc MedHome page
C. C. Leung, W. W. Yew, K. C. Chang, C. M. Tam, C. K. Chan, W. S. Law, M. Y. Wong, S. N. Lee, and M. Leung
Risk of Active Tuberculosis Among Schoolchildren in Hong Kong
Arch Pediatr Adolesc Med, March 1, 2006; 160(3): 247 - 251.
[Abstract] [Full Text] [PDF]

Home page
 CVIHome page
R. Phillips, C. Horsfield, S. Kuijper, S. F. Sarfo, J. Obeng-Baah, S. Etuaful, B. Nyamekye, P. Awuah, K. M. Nyarko, F. Osei-Sarpong, et al.
Cytokine Response to Antigen Stimulation of Whole Blood from Patients with Mycobacterium ulcerans Disease Compared to That from Patients with Tuberculosis
Clin. Vaccine Immunol., February 1, 2006; 13(2): 253 - 257.
[Abstract] [Full Text] [PDF]

Home page
 CVIHome page
E. Porsa, L. Cheng, M. M. Seale, G. L. Delclos, X. Ma, R. Reich, J. M. Musser, and E. A. Graviss
Comparison of a New ESAT-6/CFP-10 Peptide-Based Gamma Interferon Assay and a Tuberculin Skin Test for Tuberculosis Screening in a Moderate-Risk Population
Clin. Vaccine Immunol., January 1, 2006; 13(1): 53 - 58.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
F. Piana, L. R. Codecasa, G. Besozzi, G. B. Migliori, and D. M. Cirillo
Use of Commercial Interferon-{gamma} Assays in Immunocompromised Patients for Tuberculosis Diagnosis
Am. J. Respir. Crit. Care Med., January 1, 2006; 173(1): 130 - 130.
[Full Text] [PDF]

Home page
 CVIHome page
D. Goletti, D. Vincenti, S. Carrara, O. Butera, F. Bizzoni, G. Bernardini, M. Amicosante, and E. Girardi
Selected RD1 Peptides for Active Tuberculosis Diagnosis: Comparison of a Gamma Interferon Whole-Blood Enzyme-Linked Immunosorbent Assay and an Enzyme-Linked Immunospot Assay
Clin. Vaccine Immunol., November 1, 2005; 12(11): 1311 - 1316.
[Abstract] [Full Text] [PDF]

Home page
 Int ImmunolHome page
A. Marei, A. Ghaemmaghami, P. Renshaw, M. Wiselka, M. Barer, M. Carr, and L. Ziegler-Heitbrock
Superior T cell activation by ESAT-6 as compared with the ESAT-6-CFP-10 complex
Int. Immunol., November 1, 2005; 17(11): 1439 - 1446.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
H. Shams, S. E. Weis, P. Klucar, A. Lalvani, P. K. Moonan, J. M. Pogoda, K. Ewer, and P. F. Barnes
Enzyme-linked Immunospot and Tuberculin Skin Testing to Detect Latent Tuberculosis Infection
Am. J. Respir. Crit. Care Med., November 1, 2005; 172(9): 1161 - 1168.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
M. Pai and D. M. Lewinsohn
Interferon-{gamma} Assays for Tuberculosis: Is Anergy the Achilles' Heel?
Am. J. Respir. Crit. Care Med., September 1, 2005; 172(5): 519 - 521.
[Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
G. Ferrara, M. Losi, M. Meacci, B. Meccugni, R. Piro, P. Roversi, B. M. Bergamini, R. D'Amico, P. Marchegiano, F. Rumpianesi, et al.
Routine Hospital Use of a New Commercial Whole Blood Interferon-{gamma} Assay for the Diagnosis of Tuberculosis Infection
Am. J. Respir. Crit. Care Med., September 1, 2005; 172(5): 631 - 635.
[Abstract] [Full Text] [PDF]

Home page
 Ann Rheum DisHome page
D Ponce de Leon, E Acevedo-Vasquez, A Sanchez-Torres, M Cucho, J Alfaro, R Perich, C Pastor, J Harrison, and C Sanchez-Schwartz
Attenuated response to purified protein derivative in patients with rheumatoid arthritis: study in a population with a high prevalence of tuberculosis
Ann Rheum Dis, September 1, 2005; 64(9): 1360 - 1361.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
K. Dheda, J.-S. Chang, R. A. M. Breen, L. U. Kim, J. A. Haddock, J. F. Huggett, M. A. Johnson, G. A. W. Rook, and A. Zumla
In Vivo and In Vitro Studies of a Novel Cytokine, Interleukin 4{delta}2, in Pulmonary Tuberculosis
Am. J. Respir. Crit. Care Med., August 15, 2005; 172(4): 501 - 508.
[Abstract] [Full Text] [PDF]

Home page
 JAMAHome page
M. Pai, K. Gokhale, R. Joshi, S. Dogra, S. Kalantri, D. K. Mendiratta, P. Narang, C. L. Daley, R. M. Granich, G. H. Mazurek, et al.
Mycobacterium tuberculosis Infection in Health Care Workers in Rural India: Comparison of a Whole-Blood Interferon {gamma} Assay With Tuberculin Skin Testing
JAMA, June 8, 2005; 293(22): 2746 - 2755.
[Abstract] [Full Text] [PDF]

Home page
 JAMAHome page
Y. A. Kang, H. W. Lee, H. I. Yoon, B. Cho, S. K. Han, Y.-S. Shim, and J.-J. Yim
Discrepancy Between the Tuberculin Skin Test and the Whole-Blood Interferon {gamma} Assay for the Diagnosis of Latent Tuberculosis Infection in an Intermediate Tuberculosis-Burden Country
JAMA, June 8, 2005; 293(22): 2756 - 2761.
[Abstract] [Full Text] [PDF]

Home page
 JAMAHome page
H. M. Blumberg, M. K. Leonard Jr, and R. M. Jasmer
Update on the Treatment of Tuberculosis and Latent Tuberculosis Infection
JAMA, June 8, 2005; 293(22): 2776 - 2784.
[Abstract] [Full Text] [PDF]

Home page
 JAMAHome page
C. C. Whalen
Diagnosis of Latent Tuberculosis Infection: Measure for Measure
JAMA, June 8, 2005; 293(22): 2785 - 2787.
[Full Text] [PDF]

Home page
 CVIHome page
N. M. Ampel, D. K. Nelson, S. Chavez, K. A. Naus, A. B. Herman, L. Li, K. A. Simmons, and D. Pappagianis
Preliminary Evaluation of Whole-Blood Gamma Interferon Release for Clinical Assessment of Cellular Immunity in Patients with Active Coccidioidomycosis
Clin. Vaccine Immunol., June 1, 2005; 12(6): 700 - 704.
[Abstract] [Full Text] [PDF]

Home page
 CVIHome page
P. Ravn, M. E. Munk, A. B. Andersen, B. Lundgren, J. D. Lundgren, L. N. Nielsen, A. Kok-Jensen, P. Andersen, and K. Weldingh
Prospective Evaluation of a Whole-Blood Test Using Mycobacterium tuberculosis-Specific Antigens ESAT-6 and CFP-10 for Diagnosis of Active Tuberculosis
Clin. Vaccine Immunol., April 1, 2005; 12(4): 491 - 496.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
B. Nemery, W. W. Yew, R. Albert, C. Brun-Buisson, W. MacNee, F. J. Martinez, D. C. Angus, and E. Abraham
Tuberculosis, Nontuberculous Lung Infection, Pleural Disorders, Pulmonary Function, Respiratory Muscles, Occupational Lung Disease, Pulmonary Infections, and Social Issues in AJRCCM in 2004
Am. J. Respir. Crit. Care Med., March 15, 2005; 171(6): 554 - 562.
[Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
S. Banerjee, A. Nandyala, R. Podili, V. M. Katoch, K. J. R. Murthy, and S. E. Hasnain
Mycobacterium tuberculosis (Mtb) isocitrate dehydrogenases show strong B cell response and distinguish vaccinated controls from TB patients
PNAS, August 24, 2004; 101(34): 12652 - 12657.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
P. F. Barnes
Diagnosing Latent Tuberculosis Infection: Turning Glitter to Gold
Am. J. Respir. Crit. Care Med., July 1, 2004; 170(1): 5 - 6.
[Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
K. Dheda, G. Rook, A. Zumla, and T. Mori
Peripheral T Cell Interferon-{gamma} Responses and Latent Tuberculosis
Am. J. Respir. Crit. Care Med., July 1, 2004; 170(1): 97 - 98.
[Full Text]

Home page
 JOURNAL OF CORRECTIONAL HEALTH CAREHome page
C. H. Hayden, B. T. Mangura, I. Channer, G. E. Patterson, M. R. Passannante, and L. B. Reichman
Tuberculin Testing and Treatment of Latent TB Infection Among Long term Jail Inmates
Journal of Correctional Health Care, January 1, 2004; 11(1): 99 - 117.
[Abstract] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH
Proc. Am. Thorac. Soc. Am. J. Respir. Cell Mol. Biol.
Copyright © 2004 American Thoracic Society 		  ATS State of the Art 2009