Published ahead of print on September 24, 2004, doi:10.1164/rccm.200402-174OC
Am. J. Respir. Crit. Care Med., Volume 170, Number 12, December 2004, 1276-1280
A more recent version of this article appeared on December 15, 2004
Submitted on February 9, 2004
Accepted on September 20, 2004
Increased Expression of Transient Receptor Potential Vanilloid-1 in Airway Nerves of Chronic Cough
David A Groneberg1, Akio Niimi2, Q. Thai Dinh1, Borja Cosio2, Mark Hew2, Axel Fischer1, and K. Fan Chung2*
1 Department of Pediatric Pneumology and Immunology, Charite Faculty of Medicine, Humboldt-University, Berlin, Germany,
2 Department of Thoracic Medicine, National Heart and Lung Institute, London, United Kingdom
* To whom correspondence should be addressed. E-mail: f.chung{at}imperial.ac.uk.
Vanniloid receptor-1 (TRPV-1) mediates the cough response induced by the pepper extract, capsaicin, and is expressed in sensory nerves that innervate the airway wall. We determined the expression of TRPV-1 in the airways of patients with chronic persistent cough of diverse causes and with an enhanced capsaicin cough response. We obtained airway mucosal biopsies by fibreoptic bronchoscopy in 29 chronic cough patients and 16 non-coughing healthy volunteers. Immunostaining for nerve profiles with anti-PGP-9.5 antibody showed no increase in nerve profiles in the airway epithelium of chronic patients with cough; however, with an anti-TRPV-1 antibody, there was a 5-fold increase of TRPV-1 staining nerve profiles (p<0.001). There was a significant correlation between capsaicin tussive response and the number of TRPV-1 positive nerves within the patients with cough. Our findings indicate that TRPV-1 receptors may contribute to an enhanced cough reflex and the cough response in chronic persistent cough of diverse causes.
Key words: transient receptor potential vanniloid 1, capsaicin, cough, airway nerves
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